Abstract:
:Rho and rac, two members of the ras-related superfamily of small GTPases, regulate the polymerization of actin to produce stress fibers and lamellipodia, respectively. We report here that cdc42, another member of the rho family, triggers the formation of a third type of actin-based structure found at the cell periphery, filopodia. In addition to stress fibers, rho controls the assembly of focal adhesion complexes. We now show that rac and cdc42 also stimulate the assembly of multimolecular focal complexes at the plasma membrane. These complexes, which are associated with lamellipodia and filopodia, contain vinculin, paxillin, and focal adhesion kinase, but are distinct from and formed independently of rho-induced focal adhesions. Activation of cdc42 in Swiss 3T3 cells leads to the sequential activation of rac and then rho, suggesting a molecular model for the coordinated control of cell motility by members of the rho family of GTPases.
journal_name
Celljournal_title
Cellauthors
Nobes CD,Hall Adoi
10.1016/0092-8674(95)90370-4subject
Has Abstractpub_date
1995-04-07 00:00:00pages
53-62issue
1eissn
0092-8674issn
1097-4172pii
0092-8674(95)90370-4journal_volume
81pub_type
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