Nonreciprocal exchange between alleles of the yeast mitochondrial 21S rRNA gene: kinetics and the involvement of a double-strand break.

abstract：:Epidermal lineage commitment occurs when multipotent stem cells are specified to three lineages: the epidermis, the hair follicle, and the sebaceous gland (SG). How and when a lineage becomes specified remains unknown. Here, we report the existence of a population of unipotent progenitor cells that reside in the SG an...

journal_title：Cell

authors： Horsley V,O'Carroll D,Tooze R,Ohinata Y,Saitou M,Obukhanych T,Nussenzweig M,Tarakhovsky A,Fuchs E

更新日期：2006-08-11 00:00:00

abstract：:Three different cases of pancreatic beta cell hyperplasia in mice are accompanied by an increase in a subclass of cells expressing tyrosine hydroxylase (TH), a neuronal enzyme. In the nontumorigenic cases of islet growth during normal pregnancy and in the obese mutant mouse, the TH-insulin cells do not divide, in cont...

journal_title：Cell

authors： Teitelman G,Alpert S,Hanahan D

更新日期：1988-01-15 00:00:00

abstract：:The crystal structure of a proteolytic subfragment from scallop striated muscle myosin, complexed with MgADP, has been solved at 2.5 A resolution and reveals an unusual conformation of the myosin head. The converter and the lever arm are in very different positions from those in either the pre-power stroke or near-rig...

journal_title：Cell

authors： Houdusse A,Kalabokis VN,Himmel D,Szent-Györgyi AG,Cohen C

更新日期：1999-05-14 00:00:00

abstract：:Induction of broadly neutralizing antibodies (bnAbs) is a primary goal of HIV vaccine development. VRC01-class bnAbs are important vaccine leads because their precursor B cells targeted by an engineered priming immunogen are relatively common among humans. This priming immunogen has demonstrated the ability to initiat...

journal_title：Cell

authors： Briney B,Sok D,Jardine JG,Kulp DW,Skog P,Menis S,Jacak R,Kalyuzhniy O,de Val N,Sesterhenn F,Le KM,Ramos A,Jones M,Saye-Francisco KL,Blane TR,Spencer S,Georgeson E,Hu X,Ozorowski G,Adachi Y,Kubitz M,Sarkar A,Wi

更新日期：2016-09-08 00:00:00

abstract：:Pathogenic simian immunodeficiency virus (SIV) infection is associated with enteropathy, which likely contributes to AIDS progression. To identify candidate etiologies for AIDS enteropathy, we used next-generation sequencing to define the enteric virome during SIV infection in nonhuman primates. Pathogenic, but not no...

journal_title：Cell

authors： Handley SA,Thackray LB,Zhao G,Presti R,Miller AD,Droit L,Abbink P,Maxfield LF,Kambal A,Duan E,Stanley K,Kramer J,Macri SC,Permar SR,Schmitz JE,Mansfield K,Brenchley JM,Veazey RS,Stappenbeck TS,Wang D,Barouch DH,

更新日期：2012-10-12 00:00:00

abstract：:In female mammals a "random choice" mechanism decides which of the two X chromosomes will be inactivated. It has been postulated that Xist is crucial for heterochromatinization and thus functions downstream of the choice mechanism. Here we report that females heterozygous for an internal deletion in the Xist gene, whi...

journal_title：Cell

authors： Marahrens Y,Loring J,Jaenisch R

更新日期：1998-03-06 00:00:00

abstract：:The mysterious secrets of long noncoding RNAs, often referred to as the Dark Matter of the genome, are gradually coming to light. Several recent papers dig deep to reveal surprisingly complex and diverse functions of these enigmatic molecules. ...

journal_title：Cell

authors： Nagano T,Fraser P

更新日期：2011-04-15 00:00:00

abstract：:We have performed in vitro kinetic analyses of transcription from the 5S gene promoter in order to resolve the rate-limiting events which lead to accurate transcription of the 5S RNA gene. We demonstrate that a rate-limiting intermediate can be formed during an extended incubation prior to initiation of transcription....

journal_title：Cell

authors： Bieker JJ,Martin PL,Roeder RG

更新日期：1985-01-01 00:00:00

abstract：:I have defined conditions under which RepFIC plasmid DNA can be maintained in a state of lowered helical density. In exponentially growing cultures, the DNA of lowered helical density is present in small amounts but never totally absent, suggesting that it is a normal variant of plasmid maintenance. It is fully methyl...

journal_title：Cell

authors： Maas R

更新日期：2001-06-29 00:00:00

abstract：:Regulated proteolysis is essential for cell cycle progression in both prokaryotes and eukaryotes. We show here that the ClpXP protease, responsible for the degradation of multiple bacterial proteins, is dynamically localized to specific cellular positions in Caulobacter where it degrades colocalized proteins. The CtrA...

journal_title：Cell

authors： McGrath PT,Iniesta AA,Ryan KR,Shapiro L,McAdams HH

更新日期：2006-02-10 00:00:00

abstract：:Cell lines from rhabdomyosarcomas, which are tumors of muscle origin, have been used as models of CD4-independent HIV infection. These cell lines can be induced to differentiate in vitro. We report here that the vpr gene of HIV1 is sufficient for the differentiation of the human rhabdomyosarcoma cell line TE671. Diffe...

journal_title：Cell

authors： Levy DN,Fernandes LS,Williams WV,Weiner DB

更新日期：1993-02-26 00:00:00

abstract：:The CD4 lymphocyte surface glycoprotein and the lck tyrosine protein kinase p56lck are found as a complex in T lymphocytes. We have defined the domains in both proteins that are responsible for this interaction by coexpressing hybrid and deleted forms of the two proteins in HeLa cells. We have found that the unique 32...

journal_title：Cell

authors： Shaw AS,Amrein KE,Hammond C,Stern DF,Sefton BM,Rose JK

更新日期：1989-11-17 00:00:00

abstract：:The lin-12 gene of C. elegans and the Notch gene of D. melanogaster encode structurally related transmembrane proteins that mediate intercellular signaling. We show that truncated forms of these proteins consisting of only the intracellular domains cause cell fate transformations associated with constitutive activity ...

journal_title：Cell

authors： Struhl G,Fitzgerald K,Greenwald I

更新日期：1993-07-30 00:00:00

abstract：:We have transferred the mouse Ak alpha and Ak beta genes, which encode the class II I-Ak molecule, into mouse L-cell fibroblasts and hamster B cells. I-Ak molecules are expressed on the surface of both cell types. The L-cell and hamster B-cell I-Ak molecules appear normal by serological analyses and two-dimensional ge...

journal_title：Cell

authors： Malissen B,Price MP,Goverman JM,McMillan M,White J,Kappler J,Marrack P,Pierres A,Pierres M,Hood L

更新日期：1984-02-01 00:00:00

abstract：:We present evidence that the genes encoding U3 snRNA in plants are transcribed by RNA polymerase III (pol III) and not by RNA polymerase II (pol II) as in vertebrates or lower eukaryotes. The U3 gene is the only known example of a gene transcribed by different polymerases in different organisms. It is possible to conv...

journal_title：Cell

authors： Kiss T,Marshallsay C,Filipowicz W

更新日期：1991-05-03 00:00:00

abstract：:Specific active transcription units on chromosome IV in the salivary glands of Chironomus tentans have been visualized by the Miller spreading technique and in situ by conventional electron microscopy. These units are likely to be located in the two most conspicuous puffs on chromosome IV, Balbiani ring 1 (BR 1) and B...

journal_title：Cell

authors： Lamb MM,Daneholt B

更新日期：1979-08-01 00:00:00

abstract：:RGS proteins are GTPase activators for heterotrimeric G proteins. We report here the 2.8 A resolution crystal structure of the RGS protein RGS4 complexed with G(i alpha1)-Mg2+-GDP-AlF4 . Only the core domain of RGS4 is visible in the crystal. The core domain binds to the three switch regions of G(i alpha1), but does n...

journal_title：Cell

authors： Tesmer JJ,Berman DM,Gilman AG,Sprang SR

更新日期：1997-04-18 00:00:00

abstract：:Beta-arrestin1 is a multifunctional protein critically involved in signal transduction. Recently, it is also identified as a nuclear transcriptional regulator, but the underlying mechanisms and physiological significance remain to be explored. Here, we identified beta-arrestin1 as an evolutionarily conserved protein e...

journal_title：Cell

authors： Yue R,Kang J,Zhao C,Hu W,Tang Y,Liu X,Pei G

更新日期：2009-10-30 00:00:00

abstract：:Misfolded proteins accumulating in several neurodegenerative diseases (including Alzheimer, Parkinson, and Huntington diseases) can cause aggregation of their native counterparts through a mechanism similar to the infectious prion protein's induction of a pathogenic conformation onto its cellular isoform. Evidence for...

journal_title：Cell

authors： Polymenidou M,Cleveland DW

更新日期：2011-10-28 00:00:00

abstract：:The fasciclin I, II, and III glycoproteins are expressed on different subsets of axon bundles (fascicles) in insect embryos and are thus candidates for surface recognition molecules involved in growth cone guidance. Here we present the sequence of grasshopper fasciclin I and the identification and sequence of the Dros...

journal_title：Cell

authors： Zinn K,McAllister L,Goodman CS

更新日期：1988-05-20 00:00:00

abstract：:Spinocerebellar ataxia type 1 (SCA1) is one of nine inherited, typically adult onset, polyglutamine neurodegenerative diseases. To examine whether development impacts SCA1, we used a conditional transgenic mouse model of SCA1 to delay the postnatal expression of mutant ATXN1 until after completion of cerebellar develo...

journal_title：Cell

authors： Serra HG,Duvick L,Zu T,Carlson K,Stevens S,Jorgensen N,Lysholm A,Burright E,Zoghbi HY,Clark HB,Andresen JM,Orr HT

更新日期：2006-11-17 00:00:00

abstract：:Chemical modifications of histones and DNA, such as histone methylation, histone acetylation, and DNA methylation, play critical roles in epigenetic gene regulation. Many of the enzymes that add or remove such chemical modifications are known, or might be suspected, to be sensitive to changes in intracellular metaboli...

journal_title：Cell

authors： Kaelin WG Jr,McKnight SL

更新日期：2013-03-28 00:00:00

abstract：:The 75 kDa tumor necrosis factor receptor (TNFR2) transduces extracellular signals via receptor-associated cytoplasmic proteins. Two of these signal transducers, TRAF1 and TRAF2, were isolated and characterized previously. We report here the biochemical purification and subsequent molecular cloning of two novel TNFR2-...

journal_title：Cell

authors： Rothe M,Pan MG,Henzel WJ,Ayres TM,Goeddel DV

更新日期：1995-12-29 00:00:00

abstract：:Previous work from our laboratory has demonstrated that a subclass of the aminoglycoside antibiotics, those containing the drug fragment paromamine, stimulates mistranslation in cell-free protein-synthesizing systems derived from eucaryotic cells. We report here experiments which show that the ciliate Tetrahymena ther...

journal_title：Cell

authors： Palmer E,Wilhelm JM

更新日期：1978-02-01 00:00:00

abstract：:Social isolation is a stressful condition that often leads to maladaptive behaviors. In this issue of Cell, Zelikowsky et al. find that chronic social isolation stress triggers an increase in neuronal tachykinin signaling across distinct brain regions that mediate fear and aggression, elucidating the neural basis of t...

journal_title：Cell

authors： Rodriguez-Romaguera J,Stuber GD

更新日期：2018-05-17 00:00:00

abstract：:The ephrin/Eph system plays a central role in neuronal circuit formation; however, its downstream effectors are poorly understood. Here we show that alpha-chimerin Rac GTPase-activating protein mediates ephrinB3/EphA4 forward signaling. We discovered a spontaneous mouse mutation, miffy (mfy), which results in a rabbit...

journal_title：Cell

authors： Iwasato T,Katoh H,Nishimaru H,Ishikawa Y,Inoue H,Saito YM,Ando R,Iwama M,Takahashi R,Negishi M,Itohara S

更新日期：2007-08-24 00:00:00

abstract：:A new class of endogenous primate type C virus has been isolated from a continuous tissue culture line of Macaca arctoides cells by co-cultivation with a human cell line. The virus, designated MAC-1, can be transmitted to human and feline cells in tissue culture, and is unrelated, by immunological and nucleic acid hyb...

journal_title：Cell

authors： Todaro GJ,Benveniste RE,Sherwin SA,Sherr CJ

更新日期：1978-04-01 00:00:00

abstract：:Deletion analysis was carried out on the human 7SK RNA gene to map regions essential for in vitro transcription by RNA polymerase III. The sequence promoting transcription is located between 37 and 3 bp upstream of the 7SK RNA coding region. RNA polymerase III transcription of adjacent plasmid sequences can be directe...

journal_title：Cell

authors： Murphy S,Di Liegro C,Melli M

更新日期：1987-10-09 00:00:00

abstract：:The enteric bacteria Salmonella typhimurium has the ability to invade (enter) nonphagocytic cells. The internalization process occurs as a result of an intimate interaction between the bacteria and the host cell, in which S. typhimurium triggers a cascade of host cell-signaling events leading to the formation of host ...

journal_title：Cell

authors： Ginocchio CC,Olmsted SB,Wells CL,Galán JE

更新日期：1994-02-25 00:00:00

abstract：:Excessive sun tanning can result in addictive behavior. In this issue of Cell, Fell et al. utilize a combination of behavioral pharmacology and transgenic mice to demonstrate that chronic UV light exposure recruits p53 signaling in keratinocytes, subsequently increasing β-endorphin signaling at opioid receptors, and p...

journal_title：Cell

authors： Tejeda HA,Bonci A

更新日期：2014-06-19 00:00:00