Abstract：
:A new class of endogenous primate type C virus has been isolated from a continuous tissue culture line of Macaca arctoides cells by co-cultivation with a human cell line. The virus, designated MAC-1, can be transmitted to human and feline cells in tissue culture, and is unrelated, by immunological and nucleic acid hybridization criteria, to previously characterized retroviral isolates of primates. In particular, MAC-1 shows no detectable homology to the baboon type C viruses, even though viral genes related to the latter group are readily detected in M. arctoides cellular DNA. Viral gene sequences related to the MAC-1 genome are present in multiple copies (50-150 per haploid genome) in Old World primates, and are expressed in the cellular RNAs of uninfected and "virus-free" primate cells and tissues. Thus there are at least two distinct sets of genetically transmitted Old World primate type C viral genes, each of which is found in multiple copies in normal primate cellular DNA. With the description of this new retrovirus, there are now a minimum of five distinct genetically transmitted viruses of primates, three type C and type D, each represented in multiple copies in the normal cellular DNA.
journal_name
Celljournal_title
Cellauthors
Todaro GJ,Benveniste RE,Sherwin SA,Sherr CJdoi
10.1016/0092-8674(78)90227-1subject
Has Abstractpub_date
1978-04-01 00:00:00pages
775-82issue
4eissn
0092-8674issn
1097-4172pii
0092-8674(78)90227-1journal_volume
13pub_type
杂志文章相关文献
CELL文献大全abstract：:Histone lysine methylation has been linked to the recruitment of mammalian DNA repair factor 53BP1 and putative fission yeast homolog Crb2 to DNA double-strand breaks (DSBs), but how histone recognition is achieved has not been established. Here we demonstrate that this link occurs through direct binding of 53BP1 and ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2006.10.043
更新日期：2006-12-29 00:00:00
abstract：:The X-linked Foxp3 is a member of the forkhead/winged helix transcription factor family. Germline mutations cause lethal autoimmune diseases in males. Serendipitously, we observed that female mice heterozygous for the "scurfin" mutation of the Foxp3 gene (Foxp3(sf/+)) developed cancer at a high rate. The majority of t...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2007.04.034
更新日期：2007-06-29 00:00:00
abstract：:The yeast SIR2 gene is involved in regulating nucleosome phasing and transcription in the mating type system. We have found that SIR2 also plays another important role in the cell. Specifically, in wild-type SIR2 strains recombination between the tandemly repeated ribosomal RNA genes is depressed. In sir2 mutants, bot...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(89)90681-8
更新日期：1989-03-10 00:00:00
abstract：:Ubiquitin chains serve as a recognition motif for the proteasome, a multisubunit protease, which degrades its substrates into polypeptides while releasing ubiquitin for reuse. Yeast proteasomes contain two deubiquitinating enzymes, Ubp6 and Rpn11. Rpn11 promotes protein breakdown through its degradation-coupled activi...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2006.07.038
更新日期：2006-10-06 00:00:00
abstract：:Mouse macrophages and lymphocytes express two distinct isoforms of a single class of Fc receptor for IgG. The macrophage isoform (FcRII-B2) is identical to the lymphocyte isoform (FcRII-B1) except for an inframe insertion in the cytoplasmic tail of FcRII-B1 that increases its length from 47 to 94 amino acids. To deter...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(89)90846-5
更新日期：1989-07-28 00:00:00
abstract：:Prions have been responsible for an entire century of tragic episodes. Fifty years ago, kuru decimated the population of Papua New Guinea. Then, iatrogenic transmission of prions caused more than 250 cases of Creutzfeldt-Jakob disease. More recently, transmission of bovine spongiform encephalopathy to humans caused a ...
journal_title：Cell
pub_type： 杂志文章,评审
doi：10.1016/s0092-8674(03)01031-6
更新日期：2004-01-23 00:00:00
abstract：:Secretory proteins are segregated from cytosolic proteins by their translocation into the endoplasmic reticulum (ER). A modified secretory protein trapped during translocation across the ER membrane can be crosslinked to two previously identified proteins, Sec61p and BiP (Kar2p). The dependence of this cross-linking u...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(92)90415-9
更新日期：1992-04-17 00:00:00
abstract：:Human autoantibodies that recognize the spindle poles of mammals, plants, and insects were found to recognize two antigens in yeast. One of these proteins, called SPA1 (for Spindle Pole Antigen), is antigenically related to the spindle poles of a diverse set of organisms. The gene encoding SPA1 was cloned by immunoscr...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/s0092-8674(88)90977-4
更新日期：1988-09-09 00:00:00
abstract：:After translational termination, mRNA and P site deacylated tRNA remain associated with ribosomes in posttermination complexes (post-TCs), which must therefore be recycled by releasing mRNA and deacylated tRNA and by dissociating ribosomes into subunits. Recycling of bacterial post-TCs requires elongation factor EF-G ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2007.08.041
更新日期：2007-10-19 00:00:00
abstract：:A recent paper in Cell (Yao et al., 2006) and two papers in Developmental Cell (Tenzen et al., 2006; Zhang et al., 2006) identify a new receptor component for Hedgehog, a key morphogen in embryonic development. Many other proteins that bind to Hedgehog in the extracellular matrix or on the cell surface have been ident...
journal_title：Cell
pub_type： 评论,杂志文章,评审
doi：10.1016/j.cell.2006.04.016
更新日期：2006-05-05 00:00:00
abstract：:Thyroid hormone (T3) and retinoic acid (RA) receptors mediate ligand-dependent inhibition of epidermal growth factor (EGF) receptor and c-erbB2/neu promoter activities. Ligand-activated T3 and RA receptors act via a 36 bp 5' fragment of the EGF receptor gene in vivo and, in the presence of nuclear extract, bind with h...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(90)90393-s
更新日期：1990-09-21 00:00:00
abstract：:The c-Abl tyrosine kinase is inhibited by mechanisms that are poorly understood. Disruption of these mechanisms in the Bcr-Abl oncoprotein leads to several forms of human leukemia. We found that like Src kinases, c-Abl 1b is activated by phosphotyrosine ligands. Ligand-activated c-Abl is particularly sensitive to the ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/s0092-8674(03)00191-0
更新日期：2003-03-21 00:00:00
abstract：:Cancer cells enter a reversible drug-tolerant persister (DTP) state to evade death from chemotherapy and targeted agents. It is increasingly appreciated that DTPs are important drivers of therapy failure and tumor relapse. We combined cellular barcoding and mathematical modeling in patient-derived colorectal cancer mo...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2020.11.018
更新日期：2021-01-07 00:00:00
abstract：:Glucose homeostasis is strictly controlled in all domains of life. Bacteria that are unable to balance intracellular sugar levels and deal with potentially toxic phosphosugars cease growth and risk being outcompeted. Here, we identify the conserved haloacid dehalogenase (HAD)-like enzyme YigL as the previously hypothe...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2013.03.003
更新日期：2013-04-11 00:00:00
abstract：:In this issue of Cell, Yamamoto et al. (2005) describe a novel molecule, Shisa, which functions in the endoplastic reticulum (ER) to prevent maturation of Frizzled (Fz) serpentine receptors and fibroblast growth factor receptor (FGFR). Shisa thus antagonizes Wnt and FGF signaling cell-autonomously, thereby promoting a...
journal_title：Cell
pub_type： 评论,杂志文章
doi：10.1016/j.cell.2005.01.006
更新日期：2005-01-28 00:00:00
abstract：:Nucleosomes positioned over promoters are usually inhibitory to protein binding and activity. We analyzed at the nucleotide level of resolution the nucleosomal organization of a distal, liver-specific enhancer in various mouse tissues and found that the enhancer exists in an array of three precisely positioned nucleos...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(93)80079-t
更新日期：1993-10-22 00:00:00
abstract：:We have shown that the DNA sequences adjacent to the telomeres of Saccharomyces cerevisiae chromosomes are highly conserved and contain a high density of replication origins. The salient features of these telomeres can be summarized as follows. There are three moderately repetitive elements present at the telomeres: t...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(83)90437-3
更新日期：1983-06-01 00:00:00
abstract：:Autophagy is a cell-autonomous, catabolic process that plays context-dependent roles in tumor growth and progression. Wei et al. report that EGFR signaling promotes tumor growth through phosphorylation and functional inactivation of Beclin 1 and the consequent suppression of autophagy. ...
journal_title：Cell
pub_type： 评论,杂志文章
doi：10.1016/j.cell.2013.08.040
更新日期：2013-09-12 00:00:00
abstract：:Although a great deal is known biochemically about peroxiredoxins (Prxs), little is known about their real physiological function. We show here that two cytosolic yeast Prxs, cPrxI and II, which display diversity in structure and apparent molecular weights (MW), can act alternatively as peroxidases and molecular chape...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2004.05.002
更新日期：2004-05-28 00:00:00
abstract：:The state and organization of viral DNA sequences present in independently isolated rat cell lines transformed with SV40 were investigated using restriction-enzyme cleavage of the cellular DNA and blot hybridization with a viral probe. The transformed lines were established under conditions as identical as possible, e...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(80)90569-3
更新日期：1980-12-01 00:00:00
abstract：:Following DNA replication, eukaryotic cells must biorient all sister chromatids prior to cohesion cleavage at anaphase. In animal cells, sister chromatids gradually biorient during prometaphase, but current models of mitosis in S. cerevisiae assume that biorientation is established shortly after S phase. This assumpti...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2013.08.008
更新日期：2013-08-29 00:00:00
abstract：:Toxins have evolved to target regions of membrane ion channels that underlie ligand binding, gating, or ion permeation, and have thus served as invaluable tools for probing channel structure and function. Here, we describe a peptide toxin from the Earth Tiger tarantula that selectively and irreversibly activates the c...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2010.03.052
更新日期：2010-05-28 00:00:00
abstract：:Through dissecting the link between spatial genome organization and DNA replication timing, Sima et al. (2018) discover early replicating control elements (ERCEs), a new type of cis-acting elements that regulate replication timing, transcription, and multiple layers of three-dimensional features of genome organization...
journal_title：Cell
pub_type： 评论,杂志文章
doi：10.1016/j.cell.2019.01.027
更新日期：2019-02-07 00:00:00
abstract：:A temperature-sensitive mutant of BHK, designated ts BN-2, shows a rapid drop in 3H-thymidine incorporation along with accumulation of the cells in the G1 phase of the cycle when asynchronous cultures are shifted from 33.5 degrees C to the nonpermissive temperature of 39.5 degrees C. Synchronized cultures of ts BN-2 c...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(78)90017-x
更新日期：1978-10-01 00:00:00
abstract：:Hair cells are mechanosensors for the perception of sound, acceleration, and fluid motion. Mechanotransduction channels in hair cells are gated by tip links, which connect the stereocilia of a hair cell in the direction of their mechanical sensitivity. The molecular constituents of the mechanotransduction channels of ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2012.10.041
更新日期：2012-12-07 00:00:00
abstract：:Coordinated organ behavior is crucial for an effective response to environmental stimuli. By studying regeneration of hair follicles in response to patterned hair plucking, we demonstrate that organ-level quorum sensing allows coordinated responses to skin injury. Plucking hair at different densities leads to a regene...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2015.02.016
更新日期：2015-04-09 00:00:00
abstract：:Reprogramming to induced pluripotent stem cells (iPSCs) proceeds in a stepwise manner with reprogramming factor binding, transcription, and chromatin states changing during transitions. Evidence is emerging that epigenetic priming events early in the process may be critical for pluripotency induction later. Chromatin ...
journal_title：Cell
pub_type： 杂志文章,评审
doi：10.1016/j.cell.2013.02.043
更新日期：2013-03-14 00:00:00
abstract：:3.18 kb fragments of X. laevis DNA coding for tRNA 1 met have been inserted into a lambda vector via Hind III termini and cloned in E. coli. The organization of one cloned fragment has been analyzed by restriction endonuclease digestion and RNA-DNA hybridization. From the distribution of sites for three enzymes, this ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(78)90253-2
更新日期：1978-07-01 00:00:00
abstract：:The histone tails on the nucleosome surface are subject to enzyme-catalyzed modifications that may, singly or in combination, form a code specifying patterns of gene expression. Recent papers provide insights into how a combinatorial code might be set and read. They show how modification of one residue can influence t...
journal_title：Cell
pub_type： 评论,杂志文章,评审
doi：10.1016/s0092-8674(02)01080-2
更新日期：2002-11-01 00:00:00
abstract：:The role of electricity in biological systems was first appreciated through electrical stimulation experiments performed by Luigi Galvani in the 18th century. These pioneering experiments demonstrated that the behavior of living tissues is governed by the flow of electrochemical species-an insight that gave rise to th...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2017.06.026
更新日期：2017-06-29 00:00:00
