Replication Timing Becomes Intertwined with 3D Genome Organization.

Abstract:

:Through dissecting the link between spatial genome organization and DNA replication timing, Sima et al. (2018) discover early replicating control elements (ERCEs), a new type of cis-acting elements that regulate replication timing, transcription, and multiple layers of three-dimensional features of genome organization. The study has important implications for unraveling control elements of high-order genome structure and function.

journal_name

Cell

journal_title

Cell

authors

Ma J,Duan Z

doi

10.1016/j.cell.2019.01.027

subject

Has Abstract

pub_date

2019-02-07 00:00:00

pages

681-684

issue

4

eissn

0092-8674

issn

1097-4172

pii

S0092-8674(19)30090-X

journal_volume

176

pub_type

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