Abstract：
:TET-mediated 5-methyl cytosine (5mC) oxidation acts in epigenetic regulation, stem cell development, and cancer. Hu et al. now determine the crystal structure of the TET2 catalytic domain bound to DNA, shedding light on 5mC-DNA substrate recognition and the catalytic mechanism of 5mC oxidation.
journal_name
Celljournal_title
Cellauthors
Tsai CL,Tainer JAdoi
10.1016/j.cell.2013.12.002subject
Has Abstractpub_date
2013-12-19 00:00:00pages
1448-50issue
7eissn
0092-8674issn
1097-4172pii
S0092-8674(13)01532-8journal_volume
155pub_type
评论,杂志文章相关文献
CELL文献大全abstract：:The lack of in vitro prostate cancer models that recapitulate the diversity of human prostate cancer has hampered progress in understanding disease pathogenesis and therapy response. Using a 3D organoid system, we report success in long-term culture of prostate cancer from biopsy specimens and circulating tumor cells....
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2014.08.016
更新日期：2014-09-25 00:00:00
abstract：:beta-glucocerebrosidase, the enzyme defective in Gaucher disease, is targeted to the lysosome independently of the mannose-6-phosphate receptor. Affinity-chromatography experiments revealed that the lysosomal integral membrane protein LIMP-2 is a specific binding partner of beta-glucocerebrosidase. This interaction in...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2007.10.018
更新日期：2007-11-16 00:00:00
abstract：:Exchange factors for ARF GTPases (ARF-GEFs) regulate vesicle trafficking in a variety of organisms. The Arabidopsis protein GNOM is a brefeldin A (BFA) sensitive ARF-GEF that is required for the proper polar localization of PIN1, a candidate transporter of the plant hormone auxin. Mutations in GNOM lead to development...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/s0092-8674(03)00003-5
更新日期：2003-01-24 00:00:00
abstract：:The cellular complexity and scale of the early liver have constrained analyses examining its emergence during organogenesis. To circumvent these issues, we analyzed 45,334 single-cell transcriptomes from embryonic day (E)7.5, when endoderm progenitors are specified, to E10.5 liver, when liver parenchymal and non-paren...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2020.09.012
更新日期：2020-10-29 00:00:00
abstract：:The recent Zika virus outbreak highlights the need for low-cost diagnostics that can be rapidly developed for distribution and use in pandemic regions. Here, we report a pipeline for the rapid design, assembly, and validation of cell-free, paper-based sensors for the detection of the Zika virus RNA genome. By linking ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2016.04.059
更新日期：2016-05-19 00:00:00
abstract：:The monoclonal antibody ECCD-1 inhibits Ca2+-dependent cell-cell adhesion in teratocarcinoma cells, recognizing a cell surface component of MW 124,000. When mouse embryos at various preimplantation stages were cultured in the presence of ECCD-1, the compacted morphology of the 8- to 16-cell-stage embryos was destroyed...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(83)90095-8
更新日期：1983-12-01 00:00:00
abstract：:Receptor-mediated endocytosis of specific ligands is mediated through clustering of receptor-ligand complexes in coated pits on the cell surface. Following this clustering event, the ligand is internalized into a noncoated intracellular vesicle, the receptosome, which selectively avoids fusion with lysosomes and moves...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(80)90115-4
更新日期：1980-08-01 00:00:00
abstract：:Production of nerve growth factor (NGF) was assessed in cultures of human T and B lymphocytes and macrophages. NGF was constitutively produced by B cells only, which also expressed surface p140trk-A and p75NGFR molecules and hence efficiently bound and internalized the cytokine. Neutralization of endogenous NGF caused...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/s0092-8674(00)81113-7
更新日期：1996-05-03 00:00:00
abstract：:Clones containing five non-adult beta-globin genes were isolated from a library of BALB/c DNA. Together, the newly cloned regions comprise a contiguous block of 32 kb of the mouse genome. Restriction mapping of genomic DNA established the physical linkage of these non-adult genes to the two adult beta-globin genes as ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(80)90123-3
更新日期：1980-08-01 00:00:00
abstract：:Although specific microRNAs (miRNAs) can be upregulated in cancer, global miRNA downregulation is a common trait of human malignancies. The mechanisms of this phenomenon and the advantages it affords remain poorly understood. Here we identify a microRNA family, miR-103/107, that attenuates miRNA biosynthesis by target...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2010.05.017
更新日期：2010-06-25 00:00:00
abstract：:Zika virus (ZIKV) is associated with severe neuropathology in neonates as well as Guillain-Barré syndrome and other neurologic disorders in adults. Prolonged viral shedding has been reported in semen, suggesting the presence of anatomic viral reservoirs. Here we show that ZIKV can persist in cerebrospinal fluid (CSF) ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2017.04.008
更新日期：2017-05-04 00:00:00
abstract：:Signal recognition particle (SRP), a small ribonucleoprotein required for targeting secretory proteins to the ER, has three known functions: signal recognition, elongation arrest, and translocation promotion. Because SRP is inactivated by the sulfhydryl alkylating reagent N-ethylmaleimide (NEM), we have attempted to e...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(88)90529-6
更新日期：1988-01-15 00:00:00
abstract：:The nucleotide sequences of the 3' termini of the DNA from four autonomous rodent parvoviruses have been determined. The terminus of each genome exists as a Y-shaped hairpin structure involving 115 or 116 nucleotides. The sequence of this region of DNA is highly conserved and shows no evidence of internal sequence het...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(79)90276-9
更新日期：1979-07-01 00:00:00
abstract：:Global dispersal and increasing frequency of the SARS-CoV-2 spike protein variant D614G are suggestive of a selective advantage but may also be due to a random founder effect. We investigate the hypothesis for positive selection of spike D614G in the United Kingdom using more than 25,000 whole genome SARS-CoV-2 sequen...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2020.11.020
更新日期：2021-01-07 00:00:00
abstract：:Antibodies capable of neutralizing divergent influenza A viruses could form the basis of a universal vaccine. Here, from subjects enrolled in an H5N1 DNA/MIV-prime-boost influenza vaccine trial, we sorted hemagglutinin cross-reactive memory B cells and identified three antibody classes, each capable of neutralizing di...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2016.06.043
更新日期：2016-07-28 00:00:00
abstract：:The emergence of SARS-CoV-2 has driven a global research effort to identify medical countermeasures at an unprecedented pace. In this issue of Cell, Cao et al. identify thousands of SARS-CoV-2 neutralizing antibodies from convalescent donors. The authors improve our understanding of immunity against the coronavirus sp...
journal_title：Cell
pub_type： 评论,杂志文章
doi：10.1016/j.cell.2020.06.017
更新日期：2020-07-09 00:00:00
abstract：:CD4 T cells potentiate the inflammatory or humoral immune response through the action of Th1 and Th2 cells, respectively. The molecular basis of the differentiation of these cells from naive T cell precursors is, however, unclear. We found that GATA-3 was selectively expressed in Th2 cells. GATA-3 is expressed at a hi...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/s0092-8674(00)80240-8
更新日期：1997-05-16 00:00:00
abstract：:To reconstruct modern human evolutionary history and identify loci that have shaped hunter-gatherer adaptation, we sequenced the whole genomes of five individuals in each of three different hunter-gatherer populations at > 60× coverage: Pygmies from Cameroon and Khoesan-speaking Hadza and Sandawe from Tanzania. We ide...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2012.07.009
更新日期：2012-08-03 00:00:00
abstract：:Transduction of cellular genes by retroviruses requires two recombinations: one to form the left-hand junction between cellular gene and viral genome, the other to form the right-hand junction. Previous findings raised the possibility that the right-hand recombination might use RNA molecules as intermediates. We now p...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(86)90016-4
更新日期：1986-03-28 00:00:00
abstract：:The detection and discrimination of odorants in mammals is thought to be mediated by a family of 100-1000 seven transmembrane domain receptor proteins, although none of these putative olfactory receptors have been shown to bind individual odorants with high affinity. We have used a genetic approach to identify the gen...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(95)90118-3
更新日期：1995-11-03 00:00:00
abstract：:Pseudomonas exotoxin (PE) was used as a probe to study the mechanism by which protein ligands are internalized by mammalian cells. Both biochemical and electron microscopic methods were used to look at the internalization of PE by mouse LM cell fibroblasts. Our data suggest that PE enters cells by receptor-mediated en...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(80)90450-x
更新日期：1980-10-01 00:00:00
abstract：:The mitotic checkpoint ensures proper chromosome segregation by delaying anaphase until chromosomes are aligned on the spindle. Following prolonged spindle damage, however, cells eventually exit mitosis and undergo apoptosis. We show here that a murine homolog of the yeast mitotic checkpoint gene BUB1 localizes to the...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/s0092-8674(00)80255-x
更新日期：1997-05-30 00:00:00
abstract：:Maintenance of a constant cell volume in response to extracellular or intracellular osmotic changes is critical for cellular homeostasis. Activation of a ubiquitous volume-regulated anion channel (VRAC) plays a key role in this process; however, its molecular identity in vertebrates remains unknown. Here, we used a ce...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2014.03.024
更新日期：2014-04-10 00:00:00
abstract：:Plasmids expressing partial-length sense or antisense protein 4.1 RNA were microinjected into fertilized Xenopus eggs. Nuclease protection assays reveal that antisense protein 4.1 RNA lead to the specific loss of endogenous protein 4.1 transcripts after midblastula transition, with no effect on the levels of three unr...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(88)90576-4
更新日期：1988-05-20 00:00:00
abstract：:The pluripotential hemopoietic stem cells (CFU-S) of genetically resistant Fv2rr adult C57BL/6 (B6) mice can be persistently infected by Friend virus (FV) when exposed to defective spleen focus-forming virus (SFFV) and helper virus (LLV) at the time of transplantation into heavily irradiated syngeneic recipients (that...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(82)90327-0
更新日期：1982-12-01 00:00:00
abstract：:The commitment complex is the first defined step in the yeast (S. cerevisiae) splicing pathway. It contains U1 snRNP as well as Mud2p, which resembles human U2AF65. In a genetic screen, we identified the yeast gene MSL-5, which is a novel commitment complex component. Genetic and biochemical criteria indicate a direct...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/s0092-8674(00)80221-4
更新日期：1997-05-02 00:00:00
abstract：:In embryonal carcinoma (EC) cells retinoic acid (RA) strongly induces transcription from the RA receptor beta 2 (RAR beta 2) promoter through an RA response element (RARE) located in close proximity to the TATA box. Here we demonstrate that recombinant human TATA box-binding protein, hTFIID, and RAR functionally coope...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(92)90443-g
更新日期：1992-05-01 00:00:00
abstract：:Pulmonary neuroendocrine (NE) cells are neurosensory cells sparsely distributed throughout the bronchial epithelium, many in innervated clusters of 20-30 cells. Following lung injury, NE cells proliferate and generate other cell types to promote epithelial repair. Here, we show that only rare NE cells, typically 2-4 p...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2019.09.010
更新日期：2019-10-03 00:00:00
abstract：:Living organisms sense their physical environment through cellular mechanotransduction, which converts mechanical forces into electrical and biochemical signals. In turn, signal transduction serves a wide variety of functions, from basic cellular processes as diverse as proliferation, differentiation, migration, and a...
journal_title：Cell
pub_type： 杂志文章,评审
doi：10.1016/j.cell.2013.09.026
更新日期：2013-10-10 00:00:00
abstract：:The spectrin superfamily of proteins plays key roles in assembling the actin cytoskeleton in various cell types, crosslinks actin filaments, and acts as scaffolds for the assembly of large protein complexes involved in structural integrity and mechanosensation, as well as cell signaling. α-actinins in particular are t...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2014.10.056
更新日期：2014-12-04 00:00:00
