Abstract：
:While the nuclear lamin proteins (A, B, and C) assemble specifically at the surface of the nuclear membrane, their sequences do not reveal stretches of hydrophobic amino acids that might explain their association with the nuclear membranes. However, the A and B lamin proteins possess Ras-like C-terminal CaaX sequence motifs, which in Ras proteins are sites of hydrophobic modifications required for membrane association and function. From the analysis of single and double lamin A mutants affecting the CaaX motif, the nuclear localization signal, and higher-order assembly properties, we propose that the CaaX motif functions as a nonspecific, low affinity membrane probe for proteins ultimately segregated to specific cellular membrane systems. Committed association with specific membranes requires additional interactions with membrane-resident factors.
journal_name
Celljournal_title
Cellauthors
Holtz D,Tanaka RA,Hartwig J,McKeon Fdoi
10.1016/0092-8674(89)90753-8subject
Has Abstractpub_date
1989-12-22 00:00:00pages
969-77issue
6eissn
0092-8674issn
1097-4172pii
0092-8674(89)90753-8journal_volume
59pub_type
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