Abstract:
:A cDNA clone encoding a novel hematopoietic growth factor activity produced by a gibbon T cell line has been identified using a mammalian cell expression cloning system. The sequence of this cDNA proved to have significant homology to the sequence encoding murine interleukin 3 (IL-3). The human gene, which was readily identified because of its high degree of homology to the gibbon sequence, also displayed significant homology with the murine IL-3 sequence. The recombinant gibbon IL-3 protein proved to have multipotent colony stimulating activity when tested with normal human bone marrow cells, proving that this primate hematopoietin is not only structurally but also functionally related to murine IL-3.
journal_name
Celljournal_title
Cellauthors
Yang YC,Ciarletta AB,Temple PA,Chung MP,Kovacic S,Witek-Giannotti JS,Leary AC,Kriz R,Donahue RE,Wong GGdoi
10.1016/0092-8674(86)90360-0subject
Has Abstract,Author List Incompletepub_date
1986-10-10 00:00:00pages
3-10issue
1eissn
0092-8674issn
1097-4172pii
0092-8674(86)90360-0journal_volume
47pub_type
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