A cell that dies during wild-type C. elegans development can function as a neuron in a ced-3 mutant.

abstract：:Ribonucleoproteins (RNPs) mediate key cellular functions such as gene expression and its regulation. Whereas most RNP enzymes are stable in composition and harbor preformed active sites, the spliceosome, which removes noncoding introns from precursor messenger RNAs (pre-mRNAs), follows fundamentally different strategi...

journal_title：Cell

authors： Wahl MC,Will CL,Lührmann R

更新日期：2009-02-20 00:00:00

abstract：:Production of nerve growth factor (NGF) was assessed in cultures of human T and B lymphocytes and macrophages. NGF was constitutively produced by B cells only, which also expressed surface p140trk-A and p75NGFR molecules and hence efficiently bound and internalized the cytokine. Neutralization of endogenous NGF caused...

journal_title：Cell

authors： Torcia M,Bracci-Laudiero L,Lucibello M,Nencioni L,Labardi D,Rubartelli A,Cozzolino F,Aloe L,Garaci E

更新日期：1996-05-03 00:00:00

abstract：:The extracellular space (ECS) of the brain has an extremely complex spatial organization, which has defied conventional light microscopy. Consequently, despite a marked interest in the physiological roles of brain ECS, its structure and dynamics remain largely inaccessible for experimenters. We combined 3D-STED micros...

journal_title：Cell

authors： Tønnesen J,Inavalli VVGK,Nägerl UV

更新日期：2018-02-22 00:00:00

abstract：:We find that inactivation of a Drosophila homolog of the tumor suppressor APC (D-APC) causes retinal neuronal degeneration and pigment cell hypertrophy, a phenotype remarkably similar to that found in humans with germline APC mutations. Retinal degeneration in the D-APC mutant results from apoptotic cell death, which ...

journal_title：Cell

authors： Ahmed Y,Hayashi S,Levine A,Wieschaus E

更新日期：1998-06-26 00:00:00

abstract：:Partially edited mRNAs were selected by the polymerase chain reaction and sequenced. In the case of cytochrome b, 102 out of 106 clones displayed patterns of editing that were consistent with a strictly progressive 3' to 5' editing process, as predicted by the guide RNA model of RNA editing. In the case of cytochrome ...

journal_title：Cell

authors： Sturm NR,Simpson L

更新日期：1990-06-01 00:00:00

abstract：:In embryos of X. laevis, and many other species, early development requires targeted movements of molecules and molecular aggregates within the oocyte or egg cytoplasm. One well-known example in Xenopus is the aggregation of germ plasm, a group of cytoplasmic islands that become distributed during the first few cell c...

journal_title：Cell

authors： Robb DL,Heasman J,Raats J,Wylie C

更新日期：1996-11-29 00:00:00

abstract：:Propagation of a species requires periodic cell renewal to avoid clonal senescence. Liu et al. (2010) now describe a new mechanism of cell renewal in budding yeast, in which damaged protein aggregates are transported out of the daughter buds along actin cables to preserve youthfulness. ...

journal_title：Cell

authors： Guarente L

更新日期：2010-01-22 00:00:00

abstract：:Using immobilized PDGF receptor as an affinity reagent, we purified an 85 kd protein (p85) from cell lysates and we cloned its cDNA. The protein contains an SH3 domain and two SH2 domains that are homologous to domains found in several receptor-associated enzymes. Recombinant p85 overexpressed in mammalian cells inhib...

journal_title：Cell

authors： Escobedo JA,Navankasattusas S,Kavanaugh WM,Milfay D,Fried VA,Williams LT

更新日期：1991-04-05 00:00:00

abstract：:Unique among leukocytes, neutrophils follow daily cycles of release from and migration back into the bone marrow, where they are eliminated. Because removal of dying cells generates homeostatic signals, we explored whether neutrophil elimination triggers circadian events in the steady state. Here, we report that the h...

journal_title：Cell

authors： Casanova-Acebes M,Pitaval C,Weiss LA,Nombela-Arrieta C,Chèvre R,A-González N,Kunisaki Y,Zhang D,van Rooijen N,Silberstein LE,Weber C,Nagasawa T,Frenette PS,Castrillo A,Hidalgo A

更新日期：2013-05-23 00:00:00

abstract：:The HIV auxiliary protein Vpr potently blocks the cell cycle at the G2/M transition. Here, we show that G2/M arrest results from untimely activation of the structure-specific endonuclease (SSE) regulator SLX4 complex (SLX4com) by Vpr, a process that requires VPRBP-DDB1-CUL4 E3-ligase complex. Direct interaction of Vpr...

journal_title：Cell

authors： Laguette N,Brégnard C,Hue P,Basbous J,Yatim A,Larroque M,Kirchhoff F,Constantinou A,Sobhian B,Benkirane M

更新日期：2014-01-16 00:00:00

abstract：:During yeast cell division, aggregates of damaged proteins are segregated asymmetrically between the bud and the mother. It is thought that protein aggregates are cleared from the bud via actin cable-based retrograde transport toward the mother and that Bni1p formin regulates this transport. Here, we examined the dyna...

journal_title：Cell

authors： Zhou C,Slaughter BD,Unruh JR,Eldakak A,Rubinstein B,Li R

更新日期：2011-11-23 00:00:00

abstract：:Different hematopoietic cells produce minute amounts of beta-related interferon (IFN) following induction of differentiation by chemical or natural inducers. The endogenous IFN binds to type I cell surface receptors and modulates gene expression in the producer cells. We show that self-induction of two members of the ...

journal_title：Cell

authors： Resnitzky D,Yarden A,Zipori D,Kimchi A

更新日期：1986-07-04 00:00:00

abstract：:Activins are involved in the regulation of multiple biological events, ranging from early development to pituitary function. To characterize the cellular mechanisms involved in these processes, cDNAs coding for an activin receptor were cloned from AtT20 mouse corticotropic cells by screening COS cell transfectants for...

journal_title：Cell

authors： Mathews LS,Vale WW

更新日期：1991-06-14 00:00:00

abstract：:Many organisms expand the information content of their genome through enzymatic methylation of cytosine residues. Here we report the 2.8 A crystal structure of a bacterial DNA (cytosine-5)-methyltransferase (DCMtase), M. HaeIII, bound covalently to DNA. In this complex, the substrate cytosine is extruded from the DNA ...

journal_title：Cell

authors： Reinisch KM,Chen L,Verdine GL,Lipscomb WN

更新日期：1995-07-14 00:00:00

abstract：:Homologous recombination in embryonal stem cells has been used to produce a fusion oncogene, thereby mimicking chromosomal translocations that frequently result in formation of tumor-specific fusion oncogenes in human malignancies. AF9 sequences were fused into the mouse Mll gene so that expression of the Mll-AF9 fusi...

journal_title：Cell

authors： Corral J,Lavenir I,Impey H,Warren AJ,Forster A,Larson TA,Bell S,McKenzie AN,King G,Rabbitts TH

更新日期：1996-06-14 00:00:00

abstract：:Deletion analysis was carried out on the human 7SK RNA gene to map regions essential for in vitro transcription by RNA polymerase III. The sequence promoting transcription is located between 37 and 3 bp upstream of the 7SK RNA coding region. RNA polymerase III transcription of adjacent plasmid sequences can be directe...

journal_title：Cell

authors： Murphy S,Di Liegro C,Melli M

更新日期：1987-10-09 00:00:00

abstract：:The hsp 70 gene of Drosophila contains three domains to which a heat shock gene specific transcription factor (HSTF) binds. In addition to the previously described 55 bp binding domain proximal to the TAT homology, there are two 25 bp binding sites farther upstream. Footprinting studies with 5' and 3' deletion mutatio...

journal_title：Cell

authors： Topol J,Ruden DM,Parker CS

更新日期：1985-09-01 00:00:00

abstract：:In the SV40-transformed mouse embryo fibroblast cell line SVT2/S, genomic rearrangements involving the SV40 DNA and flanking host sequences were identified by Southern blot hybridization using viral DNA as probe. No rearrangements of SV40 DNA integrated into nonpermissive mouse cells have been previously described. Th...

journal_title：Cell

authors： Sager R,Anisowicz A,Howell N

更新日期：1981-01-01 00:00:00

abstract：:Little is known about how neutrophils and other cells establish a single zone of actin assembly during migration. A widespread assumption is that the leading edge prevents formation of additional fronts by generating long-range diffusible inhibitors or by sequestering essential polarity components. We use morphologica...

journal_title：Cell

authors： Houk AR,Jilkine A,Mejean CO,Boltyanskiy R,Dufresne ER,Angenent SB,Altschuler SJ,Wu LF,Weiner OD

更新日期：2012-01-20 00:00:00

abstract：:The differentiation of follicular dendritic cells (FDC) is essential to the remarkable microanatomic plasticity of lymphoid follicles. Here we show that FDC arise from ubiquitous perivascular precursors (preFDC) expressing platelet-derived growth factor receptor β (PDGFRβ). PDGFRβ-Cre-driven reporter gene recombinatio...

journal_title：Cell

authors： Krautler NJ,Kana V,Kranich J,Tian Y,Perera D,Lemm D,Schwarz P,Armulik A,Browning JL,Tallquist M,Buch T,Oliveira-Martins JB,Zhu C,Hermann M,Wagner U,Brink R,Heikenwalder M,Aguzzi A

更新日期：2012-07-06 00:00:00

abstract：:To assess telomerase as a cancer therapeutic target and determine adaptive mechanisms to telomerase inhibition, we modeled telomerase reactivation and subsequent extinction in T cell lymphomas arising in Atm(-/-) mice engineered with an inducible telomerase reverse transcriptase allele. Telomerase reactivation in the ...

journal_title：Cell

authors： Hu J,Hwang SS,Liesa M,Gan B,Sahin E,Jaskelioff M,Ding Z,Ying H,Boutin AT,Zhang H,Johnson S,Ivanova E,Kost-Alimova M,Protopopov A,Wang YA,Shirihai OS,Chin L,DePinho RA

更新日期：2012-02-17 00:00:00

abstract：:Nuclear exclusion of the forkhead transcription factor FOXO3a by protein kinase Akt contributes to cell survival. We investigated the pathological relationship between phosphoylated-Akt (Akt-p) and FOXO3a in primary tumors. Surprisingly, FOXO3a was found to be excluded from the nuclei of some tumors lacking Akt-p, sug...

journal_title：Cell

authors： Hu MC,Lee DF,Xia W,Golfman LS,Ou-Yang F,Yang JY,Zou Y,Bao S,Hanada N,Saso H,Kobayashi R,Hung MC

更新日期：2004-04-16 00:00:00

abstract：:Thyroid hormone (T3) and retinoic acid (RA) receptors mediate ligand-dependent inhibition of epidermal growth factor (EGF) receptor and c-erbB2/neu promoter activities. Ligand-activated T3 and RA receptors act via a 36 bp 5' fragment of the EGF receptor gene in vivo and, in the presence of nuclear extract, bind with h...

journal_title：Cell

authors： Hudson LG,Santon JB,Glass CK,Gill GN

更新日期：1990-09-21 00:00:00

abstract：:The assembly of COPI into a cage-like lattice sculpts membrane vesicles that transport cargo from the Golgi apparatus. Now, Lee and Goldberg (2010) present X-ray crystal structures of COPI suggesting that these coats combine selected features of two other archetypal coats, clathrin and COPII. ...

journal_title：Cell

authors： Hughson FM

更新日期：2010-07-09 00:00:00

abstract：:We have identified mutations in Drosophila endophilin to study its function in vivo. Endophilin is required presynaptically at the neuromuscular junction, and absence of Endophilin dramatically impairs endocytosis in vivo. Mutant larvae that lack Endophilin fail to take up FM1-43 dye in synaptic boutons, indicating an...

journal_title：Cell

authors： Verstreken P,Kjaerulff O,Lloyd TE,Atkinson R,Zhou Y,Meinertzhagen IA,Bellen HJ

更新日期：2002-04-05 00:00:00

abstract：:Cultured NIH 3T3 cells devoid of endogenous EGF receptors were transfected with cDNA constructs encoding either the human EGF receptor or an EGF receptor mutant in which Lys721, a key residue in the ATP binding site, was replaced with an alanine residue. The mutant receptor was properly processed, and it displayed bot...

journal_title：Cell

authors： Honegger AM,Dull TJ,Felder S,Van Obberghen E,Bellot F,Szapary D,Schmidt A,Ullrich A,Schlessinger J

更新日期：1987-10-23 00:00:00

abstract：:A study in this issue of Cell illustrates the power of applying genomic approaches with model systems to characterize the biological activity of small molecules and to identify their cellular targets, which can clarify the mode of action of human therapeutics. ...

journal_title：Cell

authors： Hughes T,Andrews B,Boone C

更新日期：2004-01-09 00:00:00

abstract：:Potassium channels embedded in cell membranes employ gates to regulate K+ current. While a specific constriction in the permeation pathway has historically been implicated in gating, recent reports suggest that the signature ion selectivity filter located in the outer membrane leaflet may be equally important. Inwardl...

journal_title：Cell

authors： Clarke OB,Caputo AT,Hill AP,Vandenberg JI,Smith BJ,Gulbis JM

更新日期：2010-06-11 00:00:00

abstract：:Tracing the lineage history of cells is key to answering diverse and fundamental questions in biology. Coupling of cell ancestry information with other molecular readouts represents an important goal in the field. Here, we describe the CRISPR array repair lineage tracing (CARLIN) mouse line and corresponding analysis ...

journal_title：Cell

authors： Bowling S,Sritharan D,Osorio FG,Nguyen M,Cheung P,Rodriguez-Fraticelli A,Patel S,Yuan WC,Fujiwara Y,Li BE,Orkin SH,Hormoz S,Camargo FD

更新日期：2020-06-11 00:00:00

abstract：:A key function of blood vessels, to supply oxygen, is impaired in tumors because of abnormalities in their endothelial lining. PHD proteins serve as oxygen sensors and may regulate oxygen delivery. We therefore studied the role of endothelial PHD2 in vessel shaping by implanting tumors in PHD2(+/-) mice. Haplodeficien...

journal_title：Cell

authors： Mazzone M,Dettori D,de Oliveira RL,Loges S,Schmidt T,Jonckx B,Tian YM,Lanahan AA,Pollard P,de Almodovar CR,De Smet F,Vinckier S,Aragonés J,Debackere K,Luttun A,Wyns S,Jordan B,Pisacane A,Gallez B,Lampugnani MG,Dej

更新日期：2009-03-06 00:00:00