Abstract：
:Mutations in the C. elegans gene ced-3 prevent almost all programmed cell deaths, so that in a ced-3 mutant there are many extra cells. We show that the pharyngeal neuron M4 is essential for feeding in wild-type worms, but in a ced-3 mutant, one of the extra cells, probably MSpaaaaap (the sister of M4), can sometimes take over M4's function. The function of MSpaaaaap, unlike that of M4, is variable and subnormal. One possible explanation is that its fate, being hidden by death and not subject to selection, has drifted randomly during evolution. We suggest that such cells may play roles in the evolution of cell lineage analogous to those played by pseudogenes in the evolution of genomes.
journal_name
Celljournal_title
Cellauthors
Avery L,Horvitz HRdoi
10.1016/0092-8674(87)90593-9subject
Has Abstractpub_date
1987-12-24 00:00:00pages
1071-8issue
6eissn
0092-8674issn
1097-4172pii
0092-8674(87)90593-9journal_volume
51pub_type
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