Abstract：
:Two studies from Jarosz et al. describe how [GAR(+)], a protein-based epigenetic determinant found mainly in wild yeast strains, can be activated by microbial cross-kingdom communication. With the aid of genetically and ecologically diverse bacteria, yeast can override an ancient regulatory mechanism of glucose repression, promoting both microbial diversity and lifespan extension.
journal_name
Celljournal_title
Cellauthors
Staniforth GL,Tuite MFdoi
10.1016/j.cell.2014.08.004subject
Has Abstractpub_date
2014-08-28 00:00:00pages
975-977issue
5eissn
0092-8674issn
1097-4172pii
S0092-8674(14)00997-0journal_volume
158pub_type
评论,杂志文章相关文献
CELL文献大全abstract：:Inward rectifier K+ channels mediate the K+ conductance at resting potential in many types of cell. Since these K+ channels do not pass outward currents (inward rectification) when the cell membrane is depolarized beyond a trigger threshold, they play an important role in controlling excitability. Both a highly voltag...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(95)90459-x
更新日期：1995-01-13 00:00:00
abstract：:We describe the comprehensive characterization of homeodomain DNA-binding specificities from a metazoan genome. The analysis of all 84 independent homeodomains from D. melanogaster reveals the breadth of DNA sequences that can be specified by this recognition motif. The majority of these factors can be organized into ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2008.05.023
更新日期：2008-06-27 00:00:00
abstract：:The phosphoinositide 3-kinase related kinases (PIKKs) mediate responses to diverse stresses, including DNA double-strand breaks (DSBs), abnormal replication fork progression, the recognition of premature termination codons in mRNAs, and inadequate nutrient availability. Rigorous control of these kinases limits cellula...
journal_title：Cell
pub_type： 杂志文章,评审
doi：10.1016/j.cell.2004.06.023
更新日期：2004-07-09 00:00:00
abstract：:Pathogenic and other cytoplasmic DNAs activate the cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) pathway to induce inflammation via transcriptional activation by IRF3 and nuclear factor κB (NF-κB), but the functional consequences of exposing cGAS to chromosomes upon mitotic nuclear envelope bre...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2019.05.035
更新日期：2019-07-11 00:00:00
abstract：:Many proteins contain disordered regions of low-sequence complexity, which cause aging-associated diseases because they are prone to aggregate. Here, we study FUS, a prion-like protein containing intrinsically disordered domains associated with the neurodegenerative disease ALS. We show that, in cells, FUS forms liqui...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2015.07.047
更新日期：2015-08-27 00:00:00
abstract：:The cpd mutation localized by T-DNA tagging on Arabidopsis chromosome 5-14.3 inhibits cell elongation controlled by the ecdysone-like brassinosteroid hormone brassinolide. The cpd mutant displays de-etiolation and derepression of light-induced genes in the dark, as well as dwarfism, male sterility, and activation of s...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/s0092-8674(00)81094-6
更新日期：1996-04-19 00:00:00
abstract：:During eukaryotic translation initiation, initiator tRNA does not insert fully into the P decoding site on the 40S ribosomal subunit. This conformation (POUT) is compatible with scanning mRNA for the AUG start codon. Base pairing with AUG is thought to promote isomerization to a more stable conformation (PIN) that arr...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2014.10.001
更新日期：2014-10-23 00:00:00
abstract：:Ethylene regulates many aspects of plant growth and development. In the presence of ethylene, the C terminus of EIN2 (EIN2C) translocates into the nucleus and activates transcription. Li et al. and Merchante et al. show that EIN2C also regulates translation through an interaction with the 3' UTRs of transcripts. ...
journal_title：Cell
pub_type： 评论,杂志文章
doi：10.1016/j.cell.2015.10.032
更新日期：2015-10-22 00:00:00
abstract：:Enhancers provide critical information directing cell-type-specific transcriptional programs, regulated by binding of signal-dependent transcription factors and their associated cofactors. Here, we report that the most strongly activated estrogen (E2)-responsive enhancers are characterized by trans-recruitment and in ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2014.08.027
更新日期：2014-10-09 00:00:00
abstract：:TOR complex 1 (TORC1) is a potent anabolic regulator of cellular growth and metabolism. When cells have sufficient amino acids, TORC1 is active due to its lysosomal localization mediated via the Rag GTPases. Upon amino acid removal, the Rag GTPases release TORC1, causing it to become cytoplasmic and inactive. We show ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2014.01.024
更新日期：2014-02-13 00:00:00
abstract：:Senescence in Podospora anserina has long been shown to be under cytoplasmic control. Comparison of DNAs isolated from young and senescent cultures made it possible to detect the presence, in senescent cultures only, of a specific DNA (SEN-DNA). This DNA consists of repeated sequences arranged in a multimeric set of c...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(80)90126-9
更新日期：1980-08-01 00:00:00
abstract：:Gram-negative bacteria have an outer membrane (OM) that functions as a barrier to protect the cell from toxic compounds such as antibiotics and detergents. The OM is a highly asymmetric bilayer composed of phospholipids, glycolipids, and proteins. Assembly of this essential organelle occurs outside the cytoplasm in an...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2005.02.015
更新日期：2005-04-22 00:00:00
abstract：:The accurate timing and execution of organelle biogenesis is crucial for cell physiology. Centriole biogenesis is regulated by Polo-like kinase 4 (Plk4) and initiates in S-phase when a daughter centriole grows from the side of a pre-existing mother. Here, we show that a Plk4 oscillation at the base of the growing cent...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2020.05.018
更新日期：2020-06-25 00:00:00
abstract：:Initiator tRNAs from the cytoplasm of salmon testes and salmon liver have been purified. The nucleotide sequence of these initiator tRNAs has been determined and found identical to that of initiator tRNA from mammalian cytoplasm. The only difference is the extent of modification of the nuceloside located between the d...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(75)90189-0
更新日期：1975-11-01 00:00:00
abstract：:xol-1 is the earliest-acting gene in the known hierarchy that controls C. elegans sex determination and dosage compensation. We show that the primary sex-determining signal (the X/A ratio) directs the choice of sexual fate by regulating xol-1 transcript levels: high xol-1 expression during gastrulation triggers male d...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(95)90452-2
更新日期：1995-01-13 00:00:00
abstract：:The actin-filled stereocilia of cochlear hair cells deflect in response to sound by pivoting around rootlets at their insertion points at the sensory cell surface. Kitajiri et al. (2010) now show that the actin-binding protein TRIOBP tightly bundles the actin filaments into rootlets, endowing these stereocilia "pivots...
journal_title：Cell
pub_type： 评论,杂志文章
doi：10.1016/j.cell.2010.05.022
更新日期：2010-05-28 00:00:00
abstract：:The fluid-mosaic model posits a liquid-like plasma membrane, which can flow in response to tension gradients. It is widely assumed that membrane flow transmits local changes in membrane tension across the cell in milliseconds, mediating long-range signaling. Here, we show that propagation of membrane tension occurs qu...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2018.09.054
更新日期：2018-12-13 00:00:00
abstract：:Yeast heat shock protein 104 (Hsp104), the only known eukaryotic disaggregase, remodels both disordered protein aggregates and cross-β sheet amyloids. To handle this diverse clientele, DeSantis et al. report that Hsp104 hexamers use distinct mechanisms-individual subunits are able to dissolve disordered aggregates, bu...
journal_title：Cell
pub_type： 评论,杂志文章
doi：10.1016/j.cell.2012.10.033
更新日期：2012-11-09 00:00:00
abstract：:Nerve regeneration and developmental outgrowth of axons are both correlated with increased synthesis of an axonal membrane protein designated GAP-43. Phosphorylation of an apparently identical protein, present at lower abundance in adult brains, has been correlated with long-term potentiation, a form of synaptic plast...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(87)90616-7
更新日期：1987-06-19 00:00:00
abstract：:Expression of pipe in the somatic tissue of the Drosophila ovary is required for the formation of embryonic dorsal-ventral polarity. pipe, which encodes an enzyme similar to the glycosaminoglycan-modifying enzyme heparan sulfate 2-O-sulfotransferase, is expressed in a spatially restricted domain of follicle cells on t...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/s0092-8674(00)81615-3
更新日期：1998-11-13 00:00:00
abstract：:The crystal structure of the β2-adrenergic receptor (β2AR) bound to the G protein adenylyl cyclase stimulatory G protein (Gs) captured the complex in a nucleotide-free state (β2AR-Gsempty). Unfortunately, the β2AR-Gsempty complex does not provide a clear explanation for G protein coupling specificity. Evidence from se...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2019.04.021
更新日期：2019-05-16 00:00:00
abstract：:Plasmids expressing partial-length sense or antisense protein 4.1 RNA were microinjected into fertilized Xenopus eggs. Nuclease protection assays reveal that antisense protein 4.1 RNA lead to the specific loss of endogenous protein 4.1 transcripts after midblastula transition, with no effect on the levels of three unr...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(88)90576-4
更新日期：1988-05-20 00:00:00
abstract：:An injection of aphidicolin into early Drosophila embryos inhibits DNA synthesis and nuclear division, while centrosome replication and many other aspects of the mitotic cycle continue. If aphidicolin is injected at nuclear cycle 7-8, the normal migration of nuclei to the embryo cortex is completely inhibited. In most...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(89)90130-x
更新日期：1989-05-19 00:00:00
abstract：:Vg1 is a TGF beta-related growth factor encoded by a maternal mRNA localized to vegetal blastomeres in Xenopus embryos. Vg1 precursor protein is abundant in vegetal cells, but the processed mature form has not been readily detected and no activity has been demonstrated for the putative Vg1 mature protein. We have engi...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(93)80045-g
更新日期：1993-08-13 00:00:00
abstract：:Periodic transcription of yeast histone genes has been demonstrated by DNA excess filter hybridization of in vivo pulse-labeled RNA isolated from synchronous cell cultures. Using strains carrying cell division cycle (cdc) mutations, we show that both activation and termination of transcription are determined by tempor...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(82)90036-8
更新日期：1982-08-01 00:00:00
abstract：:The role of various segments (gag or v-abl) of the Abelson murine leukemia virus (A-MuLV) genome in both lymphoid cell and fibroblast transformation was examined by deletion of areas from cloned, plasmid DNA representations of the genome. The deleted plasmids were tested by transfection into fibroblasts and by infecti...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(83)90389-6
更新日期：1983-09-01 00:00:00
abstract：:We have isolated two adenylyl cyclase genes, designated ACA and ACG, from Dictyostelium. The proposed structure for ACA resembles that proposed for mammalian adenylyl cyclases: two large hydrophilic domains and two sets of six transmembrane spans. ACG has a novel structure, reminiscent of the membrane-bound guanylyl c...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(92)90411-5
更新日期：1992-04-17 00:00:00
abstract：:Infections disturb metabolic homeostasis in many contexts, but the underlying connections are not completely understood. To address this, we use paired genetic and computational screens in Drosophila to identify transcriptional regulators of immunity and pathology and their associated target genes and physiologies. We...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2013.09.007
更新日期：2013-10-10 00:00:00
abstract：:A cDNA library has been constructed from an RNA preparation highly enriched in silkmoth chorion mRNAs. Many distinct clones have been identified from this library using a stepwise procedure: scoring for infrequent hexanucleotide restriction enzyme recognition sequences; detailed characterization with restriction enzym...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(79)90241-1
更新日期：1979-12-01 00:00:00
abstract：:An important signaling pathway to the actin cytoskeleton links the Rho family GTPase Cdc42 to the actin-nucleating Arp2/3 complex through N-WASP. Nevertheless, these previously identified components are not sufficient to mediate Cdc42-induced actin polymerization in a physiological context. In this paper, we describe ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2004.06.027
更新日期：2004-07-23 00:00:00
