Genetic analysis of the hormonally regulated yolk polypeptide genes in D. melanogaster.

abstract：:Subsets of long-lived, tumor-initiating stem cells often escape cancer therapies. However, sources and mechanisms that generate tumor heterogeneity and drug-resistant cell population are still unfolding. Here, we devise a functional reporter system to lineage trace and/or genetic ablate signaling in TGF-β-activated sq...

journal_title：Cell

authors： Oshimori N,Oristian D,Fuchs E

更新日期：2015-02-26 00:00:00

abstract：:The elucidation of the genetic code remains among the most influential discoveries in biology. While innumerable studies have validated the general universality of the code and its value in predicting and analyzing protein coding sequences, established and emerging work has also suggested that full genome decryption m...

journal_title：Cell

authors： Brar GA

更新日期：2016-12-15 00:00:00

abstract：:Immunofluorescent staining of a pericellular matrix produced by cultured human embryonic skin fibroblasts showed a codistribution among fibronectin, heparan sulfate proteoglycans and part of the chondroitin sulfate in a fibrillar network. Isolated matrix in an "intact" form could be scraped off the dish after detergen...

journal_title：Cell

authors： Hedman K,Johansson S,Vartio T,Kjellén L,Vaheri A,Höök M

更新日期：1982-03-01 00:00:00

abstract：:Chromosome segregation at meiosis I depends on pairing and crossing-over between homologs. In most eukaryotes, pairing culminates with formation of the proteinaceous synaptonemal complex (SC). In budding yeast, recombination initiates through double-strand DNA breaks (DSBs) and is thought to be essential for SC format...

journal_title：Cell

authors： Dernburg AF,McDonald K,Moulder G,Barstead R,Dresser M,Villeneuve AM

更新日期：1998-08-07 00:00:00

abstract：:The PML tumor suppressor controls key pathways for growth suppression, induction of apoptosis, and cellular senescence. PML loss occurs frequently in human tumors through unknown posttranslational mechanisms. Casein kinase 2 (CK2) is oncogenic and frequently upregulated in human tumors. Here we show that CK2 regulates...

journal_title：Cell

authors： Scaglioni PP,Yung TM,Cai LF,Erdjument-Bromage H,Kaufman AJ,Singh B,Teruya-Feldstein J,Tempst P,Pandolfi PP

更新日期：2006-07-28 00:00:00

abstract：:NRK fibroblasts exposed to transforming growth factor-beta (TGF-beta) show increased binding of radiolabeled epidermal growth factor (EGF) relative to untreated cells. The binding of another growth factor, rat insulin-like growth factor-II, is unaffected. The increase in EGF binding induced by TGF-beta is not due to i...

journal_title：Cell

authors： Assoian RK,Frolik CA,Roberts AB,Miller DM,Sporn MB

更新日期：1984-01-01 00:00:00

abstract：:Newly synthesized proteins are believed to move from the endoplasmic reticulum (ER) to the Golgi by bulk flow, and sorting is assumed to occur exclusively in the trans-Golgi network (TGN). Using quantitative immunoelectron microscopy, we demonstrate that vesicular stomatitis virus glycoprotein (VSV-G) is sorted from r...

journal_title：Cell

authors： Balch WE,McCaffery JM,Plutner H,Farquhar MG

更新日期：1994-03-11 00:00:00

abstract：:Mutations in the Drosophila maternal genes plutonium (plu) and pan gu (png) have the striking phenotype that DNA replication initiates in unfertilized eggs. Fertilized eggs from plu or png mutant mothers also have a mutant phenotype; DNA replication is uncoupled from nuclear division, resulting in giant, polyploid nuc...

journal_title：Cell

authors： Shamanski FL,Orr-Weaver TL

更新日期：1991-09-20 00:00:00

abstract：:At the replication origin of ColE1 plasmid, a persistent hybrid is formed between the primer precursor (RNA II) and its template DNA. The wild-type sequence in the region 13 to 20 bp upstream (-20 region) of the origin is required to form this persistent hybrid. While the template strand for transcription of this regi...

journal_title：Cell

authors： Masukata H,Tomizawa J

更新日期：1990-07-27 00:00:00

abstract：:Periodic transcription of yeast histone genes has been demonstrated by DNA excess filter hybridization of in vivo pulse-labeled RNA isolated from synchronous cell cultures. Using strains carrying cell division cycle (cdc) mutations, we show that both activation and termination of transcription are determined by tempor...

journal_title：Cell

authors： Hereford L,Bromley S,Osley MA

更新日期：1982-08-01 00:00:00

abstract：:We have fused DNA fragments derived from an Escherichia coli tRNALeu1 operon to the galK gene of E. coli to identify sequences necessary for the in vivo initiation of transcription and growth-rate-dependent regulation. Promoter sequences consisting of residues from -50 to +56 or -50 to +5 with respect to the in vivo s...

journal_title：Cell

authors： Duester G,Elford RM,Holmes WM

更新日期：1982-10-01 00:00:00

abstract：:The distribution of sense and antisense strand DNA mutations on transcribed duplex DNA contributes to the development of immune and neural systems along with the progression of cancer. Because developmentally matured B cells undergo biologically programmed strand-specific DNA mutagenesis at focal DNA/RNA hybrid struct...

journal_title：Cell

authors： Lim J,Giri PK,Kazadi D,Laffleur B,Zhang W,Grinstein V,Pefanis E,Brown LM,Ladewig E,Martin O,Chen Y,Rabadan R,Boyer F,Rothschild G,Cogné M,Pinaud E,Deng H,Basu U

更新日期：2017-04-20 00:00:00

abstract：:The location of cis-acting regulatory sequences within the long terminal repeat (LTR) of the human T cell lymphotropic virus type III (HTLV-III/LAV) was determined. An enhancer element capable of increasing the rate of transcription from a heterologous promoter, irrespective of distance and orientation, is located bet...

journal_title：Cell

authors： Rosen CA,Sodroski JG,Haseltine WA

更新日期：1985-07-01 00:00:00

abstract：:Mucus production by goblet cells of the large intestine serves as a crucial antimicrobial protective mechanism at the interface between the eukaryotic and prokaryotic cells of the mammalian intestinal ecosystem. However, the regulatory pathways involved in goblet cell-induced mucus secretion remain largely unknown. He...

journal_title：Cell

authors： Wlodarska M,Thaiss CA,Nowarski R,Henao-Mejia J,Zhang JP,Brown EM,Frankel G,Levy M,Katz MN,Philbrick WM,Elinav E,Finlay BB,Flavell RA

更新日期：2014-02-27 00:00:00

abstract：:We have constructed a gene fusion using the promoter of Drosophila hsp70 and the structural gene for Drosophila alcohol dehydrogenase (Adh) and used this construct to transform Adh-deficient flies. In these transformants, Adh is expressed only after heat shock. Like hsp70 itself, this heat-shock-inducible Adh (Adhhs) ...

journal_title：Cell

authors： Bonner JJ,Parks C,Parker-Thornburg J,Mortin MA,Pelham HR

更新日期：1984-07-01 00:00:00

abstract：:Cell differentiation is an essential process for the development, growth, reproduction, and longevity of all multicellular organisms, and its regulation has been the focus of intense investigation for the past four decades. The study of natural and induced stem cells has ushered an age of re-examination of what it mea...

journal_title：Cell

authors： Sánchez Alvarado A,Yamanaka S

更新日期：2014-03-27 00:00:00

abstract：:Enteropathogenic E. coli (EPEC) belongs to a group of bacterial pathogens that induce epithelial cell actin rearrangements resulting in pedestal formation beneath adherent bacteria. This requires the secretion of specific virulence proteins needed for signal transduction and intimate adherence. EPEC interaction induce...

journal_title：Cell

authors： Kenny B,DeVinney R,Stein M,Reinscheid DJ,Frey EA,Finlay BB

更新日期：1997-11-14 00:00:00

abstract：:T cells detect infection of cells by recognizing peptide fragments of foreign proteins bound to class I molecules of the major histocompatibility complex (MHC) on the surface of the infected cell. MHC class I molecules bind peptide in the endoplasmic reticulum, and analysis of mutant cells has demonstrated that an ade...

journal_title：Cell

authors： Shepherd JC,Schumacher TN,Ashton-Rickardt PG,Imaeda S,Ploegh HL,Janeway CA Jr,Tonegawa S

更新日期：1993-08-13 00:00:00

abstract：:As these paired Commentaries discuss, neuroscientists and architects are just beginning to collaborate, each bringing what they know about their respective fields to the task of improving the environment of research buildings and laboratories. ...

journal_title：Cell

authors： Sternberg EM,Wilson MA

更新日期：2006-10-20 00:00:00

abstract：:Transplantation of pronuclei between one-cell-stage embryos was used to construct diploid mouse embryos with two female pronuclei ( biparental gynogenones ) or two male pronuclei ( biparental androgenones ). The ability of these embryos to develop to term was compared with control nuclear-transplant embryos in which t...

journal_title：Cell

authors： McGrath J,Solter D

更新日期：1984-05-01 00:00:00

abstract：:Clinical benefits of cytokine blockade in ileal Crohn's disease (iCD) are limited to a subset of patients. Here, we applied single-cell technologies to iCD lesions to address whether cellular heterogeneity contributes to treatment resistance. We found that a subset of patients expressed a unique cellular module in inf...

journal_title：Cell

authors： Martin JC,Chang C,Boschetti G,Ungaro R,Giri M,Grout JA,Gettler K,Chuang LS,Nayar S,Greenstein AJ,Dubinsky M,Walker L,Leader A,Fine JS,Whitehurst CE,Mbow ML,Kugathasan S,Denson LA,Hyams JS,Friedman JR,Desai PT,Ko

更新日期：2019-09-05 00:00:00

abstract：:We have examined the chromatin structure of a repeated cluster of tRNA genes of Xenopus laevis, with particular attention to possible phase relationships between nucleosomes and the underlying tDNA sequence. In transcriptionally active liver and cultured kidney cells, essentially all tDNA is packaged into regularly sp...

journal_title：Cell

authors： Bryan PN,Hofstetter H,Birnstiel ML

更新日期：1981-12-01 00:00:00

abstract：:The inhibitor of apoptosis (IAP) proteins suppress cell death by inhibiting the catalytic activity of caspases. Here we present the crystal structure of caspase-7 in complex with a potent inhibitory fragment from XIAP at 2.45 A resolution. An 18-residue XIAP peptide binds the catalytic groove of caspase-7, making exte...

journal_title：Cell

authors： Chai J,Shiozaki E,Srinivasula SM,Wu Q,Datta P,Alnemri ES,Shi Y

更新日期：2001-03-09 00:00:00

abstract：:We are undertaking a genetic approach to investigate the role that synaptic modulation in the mammalian central nervous system plays in learning and memory and to identify relevant molecular components. We have generated mice deficient in the gamma isoform of protein kinase C (PKC gamma), an enzyme that has previously...

journal_title：Cell

authors： Abeliovich A,Paylor R,Chen C,Kim JJ,Wehner JM,Tonegawa S

更新日期：1993-12-31 00:00:00

abstract：:Proteolytic fragments of human plasma fibronectin were used to identify monoclonal antibodies reacting with the various domains of fibronectin. One of these antibodies, which reacts with cell-attachment-promoting fragments of fibronectin, inhibits attachment of cells to fibronectin-coated surfaces. A cell-attachment-p...

journal_title：Cell

authors： Pierschbacher MD,Hayman EG,Ruoslahti E

更新日期：1981-10-01 00:00:00

abstract：:The development of solid tumors is regulated by dynamic interactions between evolving neoplastic cells and their microenvironment. Luo et al. (2007) recently demonstrated that tumor-infiltrating immune cells expressing RANKL induce activation and nuclear localization of IKKalpha in prostatic epithelial tumor cells. Th...

journal_title：Cell

authors： Affara NI,Coussens LM

更新日期：2007-04-06 00:00:00

abstract：:AMPA-type glutamate receptors (AMPA-Rs) mediate a majority of excitatory synaptic transmission in the brain. In hippocampus, most AMPA-Rs are hetero-oligomers composed of GluR1/GluR2 or GluR2/GluR3 subunits. Here we show that these AMPA-R forms display different synaptic delivery mechanisms. GluR1/GluR2 receptors are ...

journal_title：Cell

authors： Shi S,Hayashi Y,Esteban JA,Malinow R

更新日期：2001-05-04 00:00:00

abstract：:We describe the purification and characterization of ACF, an ATP-utilizing chromatin assembly and remodeling factor. ACF is a multisubunit factor that contains ISWI protein and is distinct from NURF, another ISWI-containing factor. In chromatin assembly, purified ACF and a core histone chaperone (such as NAP-1 or CAF-...

journal_title：Cell

authors： Ito T,Bulger M,Pazin MJ,Kobayashi R,Kadonaga JT

更新日期：1997-07-11 00:00:00

abstract：:Cellular mRNAs exist in messenger ribonucleoprotein (mRNP) complexes, which undergo transitions during the lifetime of the mRNAs and direct posttranscriptional gene regulation. A final posttranscriptional step in gene expression is the turnover of the mRNP, which involves degradation of the mRNA and recycling of assoc...

journal_title：Cell

authors： Franks TM,Singh G,Lykke-Andersen J

更新日期：2010-12-10 00:00:00

abstract：:A novel method of affinity chromatography on insolubilized collagen-binding fragments of fibronectin was utilized to isolate a random-coil collagenous protein from culture media of mouse teratocarcinoma-derived endodermal cells. These cells also produced another collagenous protein, which did not bind to fibronectin b...

journal_title：Cell

authors： Engvall E,Bell ML,Carlsson RN,Miller EJ,Ruoslahti E

更新日期：1982-06-01 00:00:00