Abstract:
:We have localized ten oxi3- mutations in the first, al1, intron of the coxl gene. All are splicing deficient, being unable to excise the intron. Complementation experiments disclose several domains in the intron al1: the 5'-proximal and 3'-proximal domains harbor cis-dominant mutations, while trans-recessive ones are located in the intron's open reading frame. Comprehensive analyses of allele-specific polypeptides accumulating in mutants show that they result from the translation of the intron's ORF. We conclude that a specific mRNA maturase involved in splicing of oxidase mRNA is encoded by the intron al1 in a manner similar to the cytochrome b mRNA maturase.
journal_name
Celljournal_title
Cellauthors
Carignani G,Groudinsky O,Frezza D,Schiavon E,Bergantino E,Slonimski PPdoi
10.1016/0092-8674(83)90106-xsubject
Has Abstractpub_date
1983-12-01 00:00:00pages
733-42issue
3 Pt 2eissn
0092-8674issn
1097-4172pii
0092-8674(83)90106-Xjournal_volume
35pub_type
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