Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery.

Abstract:

:Growth factors can promote cell survival by activating the phosphatidylinositide-3'-OH kinase and its downstream target, the serine-threonine kinase Akt. However, the mechanism by which Akt functions to promote survival is not understood. We show that growth factor activation of the PI3'K/Akt signaling pathway culminates in the phosphorylation of the BCL-2 family member BAD, thereby suppressing apoptosis and promoting cell survival. Akt phosphorylates BAD in vitro and in vivo, and blocks the BAD-induced death of primary neurons in a site-specific manner. These findings define a mechanism by which growth factors directly inactivate a critical component of the cell-intrinsic death machinery.

journal_name

Cell

journal_title

Cell

authors

Datta SR,Dudek H,Tao X,Masters S,Fu H,Gotoh Y,Greenberg ME

doi

10.1016/s0092-8674(00)80405-5

subject

Has Abstract

pub_date

1997-10-17 00:00:00

pages

231-41

issue

2

eissn

0092-8674

issn

1097-4172

pii

S0092-8674(00)80405-5

journal_volume

91

pub_type

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