Abstract：
:We have analyzed the generation of unexpected patterns of RNA editing, i.e., those not following a strict 3' to 5' progression, which occur in junction regions between fully edited and preedited sequences. Evidence is presented that these patterns are generated by misediting due to specific events of misguiding. Misediting can occur through the interaction of inappropriate gRNAs with mRNAs or appropriate gRNAs in an incorrect fashion. Four possible mechanisms for the generation of misedited sequences are presented. Chimeric molecules have been detected in steady-state mitochondrial RNAs that are composed of misguiding gRNAs covalently linked to mRNAs at misediting sites by the 3' oligo(U) tail. We propose that misediting within junction regions can be corrected by appropriately acting gRNAs.
journal_name
Celljournal_title
Cellauthors
Sturm NR,Maslov DA,Blum B,Simpson Ldoi
10.1016/0092-8674(92)90171-8subject
Has Abstractpub_date
1992-08-07 00:00:00pages
469-76issue
3eissn
0092-8674issn
1097-4172pii
0092-8674(92)90171-8journal_volume
70pub_type
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