Generation of unexpected editing patterns in Leishmania tarentolae mitochondrial mRNAs: misediting produced by misguiding.

Abstract:

:We have analyzed the generation of unexpected patterns of RNA editing, i.e., those not following a strict 3' to 5' progression, which occur in junction regions between fully edited and preedited sequences. Evidence is presented that these patterns are generated by misediting due to specific events of misguiding. Misediting can occur through the interaction of inappropriate gRNAs with mRNAs or appropriate gRNAs in an incorrect fashion. Four possible mechanisms for the generation of misedited sequences are presented. Chimeric molecules have been detected in steady-state mitochondrial RNAs that are composed of misguiding gRNAs covalently linked to mRNAs at misediting sites by the 3' oligo(U) tail. We propose that misediting within junction regions can be corrected by appropriately acting gRNAs.

journal_name

Cell

journal_title

Cell

authors

Sturm NR,Maslov DA,Blum B,Simpson L

doi

10.1016/0092-8674(92)90171-8

subject

Has Abstract

pub_date

1992-08-07 00:00:00

pages

469-76

issue

3

eissn

0092-8674

issn

1097-4172

pii

0092-8674(92)90171-8

journal_volume

70

pub_type

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