Abstract：
:The formation of morphogen gradients is essential for tissue patterning. Morphogens are released from producing cells and spread through adjacent tissue; paradoxically, however, many morphogens, including Wingless, associate tightly with the cell membrane. Here, we describe a novel cell biological mechanism that disperses membrane fragments over large distances through the Drosophila imaginal disc epithelium. We call these membrane exovesicles argosomes. Argosomes are derived from basolateral membranes and are produced by many different regions of the disc. They travel through adjacent tissue where they are found predominantly in endosomes. Wingless protein colocalizes with argosomes derived from Wingless-producing cells. The properties of argosomes are consistent with their being a vehicle for the spread of Wingless protein.
journal_name
Celljournal_title
Cellauthors
Greco V,Hannus M,Eaton Sdoi
10.1016/s0092-8674(01)00484-6subject
Has Abstractpub_date
2001-09-07 00:00:00pages
633-45issue
5eissn
0092-8674issn
1097-4172pii
S0092-8674(01)00484-6journal_volume
106pub_type
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