Abstract:
:Major depressive disorder (MDD) patients display a common but often variable set of symptoms making successful, sustained treatment difficult to achieve. Separate depressive symptoms may be encoded by differential changes in distinct circuits in the brain, yet how discrete circuits underlie behavioral subsets of depression and how they adapt in response to stress has not been addressed. We identify two discrete circuits of parvalbumin-positive (PV) neurons in the ventral pallidum (VP) projecting to either the lateral habenula or ventral tegmental area contributing to depression. We find that these populations undergo different electrophysiological adaptations in response to social defeat stress, which are normalized by antidepressant treatment. Furthermore, manipulation of each population mediates either social withdrawal or behavioral despair, but not both. We propose that distinct components of the VP PV circuit can subserve related, yet separate depressive-like phenotypes in mice, which could ultimately provide a platform for symptom-specific treatments of depression.
journal_name
Celljournal_title
Cellauthors
Knowland D,Lilascharoen V,Pacia CP,Shin S,Wang EH,Lim BKdoi
10.1016/j.cell.2017.06.015subject
Has Abstractpub_date
2017-07-13 00:00:00pages
284-297.e18issue
2eissn
0092-8674issn
1097-4172pii
S0092-8674(17)30698-0journal_volume
170pub_type
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