Distinct Ventral Pallidal Neural Populations Mediate Separate Symptoms of Depression.

Abstract:

:Major depressive disorder (MDD) patients display a common but often variable set of symptoms making successful, sustained treatment difficult to achieve. Separate depressive symptoms may be encoded by differential changes in distinct circuits in the brain, yet how discrete circuits underlie behavioral subsets of depression and how they adapt in response to stress has not been addressed. We identify two discrete circuits of parvalbumin-positive (PV) neurons in the ventral pallidum (VP) projecting to either the lateral habenula or ventral tegmental area contributing to depression. We find that these populations undergo different electrophysiological adaptations in response to social defeat stress, which are normalized by antidepressant treatment. Furthermore, manipulation of each population mediates either social withdrawal or behavioral despair, but not both. We propose that distinct components of the VP PV circuit can subserve related, yet separate depressive-like phenotypes in mice, which could ultimately provide a platform for symptom-specific treatments of depression.

journal_name

Cell

journal_title

Cell

authors

Knowland D,Lilascharoen V,Pacia CP,Shin S,Wang EH,Lim BK

doi

10.1016/j.cell.2017.06.015

subject

Has Abstract

pub_date

2017-07-13 00:00:00

pages

284-297.e18

issue

2

eissn

0092-8674

issn

1097-4172

pii

S0092-8674(17)30698-0

journal_volume

170

pub_type

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