Abstract:
:Mutations in the single-minded (sim) gene of Drosophila result in the loss of the precursor cells giving rise to the midline cells of the embryonic central nervous system. We have examined the structure of the sim product by sequencing a sim cDNA clone, and have also determined the subcellular localization of the protein and its developmental expression by staining embryos with an antiserum against a sim fusion protein. The results indicate that sim is a nuclear protein specifically expressed along the midline of the neuroepithelium, the same subset of cells that are missing in the mutant. No similarity is observed between sim and any known nuclear protein, but, surprisingly, it is similar to the Drosophila period (per) locus gene product, which controls the periodicity of biological rhythms.
journal_name
Celljournal_title
Cellauthors
Crews ST,Thomas JB,Goodman CSdoi
10.1016/0092-8674(88)90538-7subject
Has Abstractpub_date
1988-01-15 00:00:00pages
143-51issue
1eissn
0092-8674issn
1097-4172pii
0092-8674(88)90538-7journal_volume
52pub_type
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