The discovery of statins.

abstract：:Using X-ray crystallography, we have directly observed the path of mRNA in the 70S ribosome in Fourier difference maps at 7 A resolution. About 30 nucleotides of the mRNA are wrapped in a groove that encircles the neck of the 30S subunit. The Shine-Dalgarno helix is bound in a large cleft between the head and the back...

journal_title：Cell

authors： Yusupova GZ,Yusupov MM,Cate JH,Noller HF

更新日期：2001-07-27 00:00:00

abstract：:Induction of broadly neutralizing antibodies (bnAbs) is a primary goal of HIV vaccine development. VRC01-class bnAbs are important vaccine leads because their precursor B cells targeted by an engineered priming immunogen are relatively common among humans. This priming immunogen has demonstrated the ability to initiat...

journal_title：Cell

authors： Briney B,Sok D,Jardine JG,Kulp DW,Skog P,Menis S,Jacak R,Kalyuzhniy O,de Val N,Sesterhenn F,Le KM,Ramos A,Jones M,Saye-Francisco KL,Blane TR,Spencer S,Georgeson E,Hu X,Ozorowski G,Adachi Y,Kubitz M,Sarkar A,Wi

更新日期：2016-09-08 00:00:00

abstract：:The mammalian BAF complex regulates gene expression by modifying chromatin structure. In this report, we identify 80 genes activated and 2 genes repressed by the BAF complex in SW-13 cells. We find that prior binding of NFI/CTF to the NFI/CTF binding site in CSF1 promoter is required for the recruitment of the BAF com...

journal_title：Cell

authors： Liu R,Liu H,Chen X,Kirby M,Brown PO,Zhao K

更新日期：2001-08-10 00:00:00

abstract：:Minimal hammerhead ribozymes have been characterized extensively by static and time-resolved crystallography as well as numerous biochemical analyses, leading to mutually contradictory mechanistic explanations for catalysis. We present the 2.2 A resolution crystal structure of a full-length Schistosoma mansoni hammerh...

journal_title：Cell

authors： Martick M,Scott WG

更新日期：2006-07-28 00:00:00

abstract：:In many cases the multiple genes coding for one specific tRNA are dispersed throughout the genome. The members of such a gene family nevertheless maintain a common nucleotide sequence during evolution. A major mechanism contributing to this concerted evolution is intergenic conversion. Here we show that it occurs betw...

journal_title：Cell

authors： Amstutz H,Munz P,Heyer WD,Leupoid U,Kohli J

更新日期：1985-04-01 00:00:00

abstract：:Purified reovirus synthesizes in vitro a mixture of mRNA molecules that contain 5' terminal structures of the type ppG..., GpppG..., and m7GpppGm, the relative amount of each depending upon the presence of S-adenosylmethionine (SAM) or S-adenosylhomocysteine (SAH) in the transcription incubation mixture. Reovirus mRNA...

journal_title：Cell

authors： Both GW,Furuichi Y,Muthukrishnan S,Shatkin AJ

更新日期：1975-10-01 00:00:00

abstract：:What happens to organelles during mitosis, and how they are apportioned to each of the daughter cells, is not completely clear. We have devised a procedure to address whether Golgi membranes fuse with the Endoplasmic Reticulum (ER) during mitosis via the detection of interactions between ER and Golgi proteins. This pr...

journal_title：Cell

authors： Pecot MY,Malhotra V

更新日期：2004-01-09 00:00:00

abstract：:Neuronal plasticity depends on plasma membrane Ca(2+) influx, resulting in activity-dependent gene transcription. Calmodulin (CaM) activated by Ca(2+) initiates the nuclear events, but how CaM makes its way to the nucleus has remained elusive. Ma et al. now show that CaMKIIγ transports CaM from cell surface Ca(2+) cha...

journal_title：Cell

authors： Malik ZA,Stein IS,Navedo MF,Hell JW

更新日期：2014-10-09 00:00:00

abstract：:MiRNAs are regulatory molecules that can be packaged into exosomes and secreted from cells. Here, we show that adipose tissue macrophages (ATMs) in obese mice secrete miRNA-containing exosomes (Exos), which cause glucose intolerance and insulin resistance when administered to lean mice. Conversely, ATM Exos obtained f...

journal_title：Cell

authors： Ying W,Riopel M,Bandyopadhyay G,Dong Y,Birmingham A,Seo JB,Ofrecio JM,Wollam J,Hernandez-Carretero A,Fu W,Li P,Olefsky JM

更新日期：2017-10-05 00:00:00

abstract：:GroEL and GroES form a chaperonin nano-cage for proteins up to approximately 60 kDa to fold in isolation. Here we explored the structural features of the chaperonin cage critical for rapid folding of encapsulated substrates. Modulating the volume of the GroEL central cavity affected folding speed in accordance with co...

journal_title：Cell

authors： Tang YC,Chang HC,Roeben A,Wischnewski D,Wischnewski N,Kerner MJ,Hartl FU,Hayer-Hartl M

更新日期：2006-06-02 00:00:00

abstract：:After three or more passages, stromal cell outgrowths from explants of normal rabbit corneas and from corneas previously burned with alkali did not produce collagenase until they were stimulated by the addition of rabbit blood-derived mononuclear cells or media conditioned by them. Normal stromal cells required stimul...

journal_title：Cell

authors： Newsome DA,Gross J

更新日期：1979-04-01 00:00:00

abstract：:Peptide hormone fibroblast growth factor-21 (FGF21) has insulin-mimetic properties. Dutchak et al. now suggest that FGF21 also acts in an autocrine fashion in adipocytes and is required to mediate effects of the PPARγ agonist class of antidiabetic drugs. Does this new property improve FGF21's fledgling clinical prospe...

journal_title：Cell

authors： Qiang L,Accili D

更新日期：2012-02-03 00:00:00

abstract：:Polyglycylation is a posttranslational modification that generates glycine side chains on proteins. Here we identify a family of evolutionarily conserved glycine ligases that modify tubulin using different enzymatic mechanisms. In mammals, two distinct enzyme types catalyze the initiation and elongation steps of polyg...

journal_title：Cell

authors： Rogowski K,Juge F,van Dijk J,Wloga D,Strub JM,Levilliers N,Thomas D,Bré MH,Van Dorsselaer A,Gaertig J,Janke C

更新日期：2009-06-12 00:00:00

abstract：:Mouse embryonic stem (ES) cells grown in serum exhibit greater heterogeneity in morphology and expression of pluripotency factors than ES cells cultured in defined medium with inhibitors of two kinases (Mek and GSK3), a condition known as "2i" postulated to establish a naive ground state. We show that the transcriptom...

journal_title：Cell

authors： Marks H,Kalkan T,Menafra R,Denissov S,Jones K,Hofemeister H,Nichols J,Kranz A,Stewart AF,Smith A,Stunnenberg HG

更新日期：2012-04-27 00:00:00

abstract：:Inconsistent with the view that hair follicle stem cells reside in the matrix area of the hair bulb, we found that label-retaining cells exist exclusively in the bulge area of the mouse hair follicle. The bulge consists of a subpopulation of outer root sheath cells located in the midportion of the follicle at the arre...

journal_title：Cell

authors： Cotsarelis G,Sun TT,Lavker RM

更新日期：1990-06-29 00:00:00

abstract：:The v-erbB gene product of avian erythroblastosis virus (AEV) has extensive homology with the receptor for epidermal growth factor (EGF). We report here that chicken embryo fibroblasts (CEF) transformed by AEV show enhanced tyrosine phosphorylation of a number of cellular polypeptides, including the 36 kd protein, whi...

journal_title：Cell

authors： Gilmore T,DeClue JE,Martin GS

更新日期：1985-03-01 00:00:00

abstract：:Microbial populations can maximize fitness in dynamic environments through bet hedging, a process wherein a subpopulation assumes a phenotype not optimally adapted to the present environment but well adapted to an environment likely to be encountered. Here, we show that oxygen induces fluctuating expression of the tri...

journal_title：Cell

authors： Carey JN,Mettert EL,Roggiani M,Myers KS,Kiley PJ,Goulian M

更新日期：2018-03-22 00:00:00

abstract：:Microbial functions in the host physiology are a result of the microbiota-host co-evolution. We show that cold exposure leads to marked shift of the microbiota composition, referred to as cold microbiota. Transplantation of the cold microbiota to germ-free mice is sufficient to increase insulin sensitivity of the host...

journal_title：Cell

authors： Chevalier C,Stojanović O,Colin DJ,Suarez-Zamorano N,Tarallo V,Veyrat-Durebex C,Rigo D,Fabbiano S,Stevanović A,Hagemann S,Montet X,Seimbille Y,Zamboni N,Hapfelmeier S,Trajkovski M

更新日期：2015-12-03 00:00:00

abstract：:The advent of H7N9 in early 2013 is of concern for a number of reasons, including its capability to infect humans, the lack of clarity in the etiology of infection, and because the human population does not have pre-existing immunity to the H7 subtype. Earlier sequence analyses of H7N9 hemagglutinin (HA) point to amin...

journal_title：Cell

authors： Tharakaraman K,Jayaraman A,Raman R,Viswanathan K,Stebbins NW,Johnson D,Shriver Z,Sasisekharan V,Sasisekharan R

更新日期：2013-06-20 00:00:00

abstract：:Interactions between similar but not identical (homeologous) DNA sequences play an important biological role in the evolution of genes and genomes. To gain insight into the underlying molecular mechanism(s) of genetic recombination, we have studied inter- and intramolecular homeologous recombination in S. cerevisiae d...

journal_title：Cell

authors： Mézard C,Pompon D,Nicolas A

更新日期：1992-08-21 00:00:00

abstract：:The recent Zika virus outbreak highlights the need for low-cost diagnostics that can be rapidly developed for distribution and use in pandemic regions. Here, we report a pipeline for the rapid design, assembly, and validation of cell-free, paper-based sensors for the detection of the Zika virus RNA genome. By linking ...

journal_title：Cell

authors： Pardee K,Green AA,Takahashi MK,Braff D,Lambert G,Lee JW,Ferrante T,Ma D,Donghia N,Fan M,Daringer NM,Bosch I,Dudley DM,O'Connor DH,Gehrke L,Collins JJ

更新日期：2016-05-19 00:00:00

abstract：:Members of the E2F transcription factor family (E2F-1-E2F-5) are believed to be critical positive regulators of cell cycle progression in eukaryotes although the in vivo functions of the individual E2Fs have not been elucidated. Mice were generated that lack E2F-1 and, surprisingly, these mice develop and reproduce no...

journal_title：Cell

authors： Field SJ,Tsai FY,Kuo F,Zubiaga AM,Kaelin WG Jr,Livingston DM,Orkin SH,Greenberg ME

更新日期：1996-05-17 00:00:00

abstract：:Drosophila bicoid mRNA is synthesized in the nurse cells and transported to the oocyte where microtubules and Exuperantia protein mediate localization to the anterior pole. Fluorescent bicoid mRNA injected into the oocyte displays nonpolar microtubule-dependent transport to the closest cortical surface, and the oocyte...

journal_title：Cell

authors： Cha BJ,Koppetsch BS,Theurkauf WE

更新日期：2001-07-13 00:00:00

abstract：:DNA interstrand crosslinks (ICLs) are toxic DNA lesions whose repair occurs in the S phase of metazoans via an unknown mechanism. Here, we describe a cell-free system based on Xenopus egg extracts that supports ICL repair. During DNA replication of a plasmid containing a site-specific ICL, two replication forks conver...

journal_title：Cell

authors： Räschle M,Knipscheer P,Enoiu M,Angelov T,Sun J,Griffith JD,Ellenberger TE,Schärer OD,Walter JC

更新日期：2008-09-19 00:00:00

abstract：:The mitotic checkpoint ensures proper chromosome segregation by delaying anaphase until chromosomes are aligned on the spindle. Following prolonged spindle damage, however, cells eventually exit mitosis and undergo apoptosis. We show here that a murine homolog of the yeast mitotic checkpoint gene BUB1 localizes to the...

journal_title：Cell

authors： Taylor SS,McKeon F

更新日期：1997-05-30 00:00:00

abstract：:Tissue homeostasis requires maintenance of functional integrity under stress. A central source of stress is mechanical force that acts on cells, their nuclei, and chromatin, but how the genome is protected against mechanical stress is unclear. We show that mechanical stretch deforms the nucleus, which cells initially ...

journal_title：Cell

authors： Nava MM,Miroshnikova YA,Biggs LC,Whitefield DB,Metge F,Boucas J,Vihinen H,Jokitalo E,Li X,García Arcos JM,Hoffmann B,Merkel R,Niessen CM,Dahl KN,Wickström SA

更新日期：2020-05-14 00:00:00

abstract：:The crystal structure of the snake toxin fasciculin, bound to mouse acetylcholinesterase (mAChE), at 3.2 A resolution reveals a synergistic three-point anchorage consistent with the picomolar dissociation constant of the complex. Loop II of fasciculin contains a cluster of hydrophobic residues that interact with the p...

journal_title：Cell

authors： Bourne Y,Taylor P,Marchot P

更新日期：1995-11-03 00:00:00

abstract：:Models of transcription are often built around a picture of RNA polymerase and transcription factors (TFs) acting on a single copy of a promoter. However, most TFs are shared between multiple genes with varying binding affinities. Beyond that, genes often exist at high copy number-in multiple identical copies on the c...

journal_title：Cell

authors： Brewster RC,Weinert FM,Garcia HG,Song D,Rydenfelt M,Phillips R

更新日期：2014-03-13 00:00:00

abstract：:Recent studies are beginning to shed light on the mechanism of ribosome-catalyzed peptide bond formation. ...

journal_title：Cell

authors： Green R,Lorsch JR

更新日期：2002-09-20 00:00:00

abstract：:Inward rectifier K+ channels mediate the K+ conductance at resting potential in many types of cell. Since these K+ channels do not pass outward currents (inward rectification) when the cell membrane is depolarized beyond a trigger threshold, they play an important role in controlling excitability. Both a highly voltag...

journal_title：Cell

authors： Fakler B,Brändle U,Glowatzki E,Weidemann S,Zenner HP,Ruppersberg JP

更新日期：1995-01-13 00:00:00