Trans splicing of nematode pre-messenger RNA in vitro.

abstract：:Signaling by the epidermal growth factor receptor requires an allosteric interaction between the kinase domains of two receptors, whereby one activates the other. We show that the intracellular juxtamembrane segment of the receptor, known to potentiate kinase activity, is able to dimerize the kinase domains. The C-ter...

journal_title：Cell

authors： Jura N,Endres NF,Engel K,Deindl S,Das R,Lamers MH,Wemmer DE,Zhang X,Kuriyan J

更新日期：2009-06-26 00:00:00

abstract：:Advances in genomic technology have produced an explosion of new information about the genetic basis for human disease, fueling extraordinarily high expectations for improved treatments. This perspective will take brief stock of what genetics/genomics have brought to clinical practice to date and what we might expect ...

journal_title：Cell

authors： Ginsburg D

更新日期：2011-09-30 00:00:00

abstract：:We have isolated the Drosophila melanogaster homolog (Dint-1) of int-1, a conserved cellular oncogene implicated in viral mammary tumorigenesis in mice. The deduced Dint-1 protein sequence contains 468 amino acids and starts with a hydrophobic leader; it is 54% identical to the int-1 sequence, and all 23 cysteine resi...

journal_title：Cell

authors： Rijsewijk F,Schuermann M,Wagenaar E,Parren P,Weigel D,Nusse R

更新日期：1987-08-14 00:00:00

abstract：:Many cofactors bind the hormone-activated estrogen receptor (ER), yet the specific regulators of endogenous ER-mediated gene transcription are unknown. Using chromatin immunoprecipitation (ChIP), we find that ER and a number of coactivators rapidly associate with estrogen responsive promoters following estrogen treatm...

journal_title：Cell

authors： Shang Y,Hu X,DiRenzo J,Lazar MA,Brown M

更新日期：2000-12-08 00:00:00

abstract：:ARF GTPases act at multiple steps of the secretory and vacuolar/lysosomal trafficking pathways, but little is known about the spatial regulation of ARF activation. In this issue of Cell, Geldner et al. demonstrate that the Arabidopsis ARF activator GNOM localizes to endosomes where it controls the polarized traffickin...

journal_title：Cell

authors： Bonifacino JS,Jackson CL

更新日期：2003-01-24 00:00:00

abstract：:In dividing cells, nuclear pore complexes (NPCs) disassemble during mitosis and reassemble into the newly forming nuclei. However, the fate of nuclear pores in postmitotic cells is unknown. Here, we show that NPCs, unlike other nuclear structures, do not turn over in differentiated cells. While a subset of NPC compone...

journal_title：Cell

authors： D'Angelo MA,Raices M,Panowski SH,Hetzer MW

更新日期：2009-01-23 00:00:00

abstract：:In embryos of X. laevis, and many other species, early development requires targeted movements of molecules and molecular aggregates within the oocyte or egg cytoplasm. One well-known example in Xenopus is the aggregation of germ plasm, a group of cytoplasmic islands that become distributed during the first few cell c...

journal_title：Cell

authors： Robb DL,Heasman J,Raats J,Wylie C

更新日期：1996-11-29 00:00:00

abstract：:Xenopus laevis oocytes respond to high temperature (greater than 31 degrees C) by the synthesis of one major (70 kilodalton) protein and by a gradual reduction in the rate of normal protein synthesis. In contrast with most other cells, the heat-shock response of Xenopus oocytes is controlled exclusively at the transla...

journal_title：Cell

authors： Bienz M,Gurdon JB

更新日期：1982-07-01 00:00:00

abstract：:Addition of LETS glycoprotein to normal or transformed cells produces increased migration of the cells, as determined by formation of phagokinetic tracks on gold particle-coated coverslips. These tracks arise by a combination of phagocytosis of the gold particles and cellular migration. Increased motility is also evid...

journal_title：Cell

authors： Ali IU,Hynes RO

更新日期：1978-06-01 00:00:00

abstract：:Basal cells are by definition located on the basolateral side of several epithelia, and they have never been observed reaching the lumen. Using high-resolution 3D confocal imaging, we report that basal cells extend long and slender cytoplasmic projections that not only reach toward the lumen but can cross the tight ju...

journal_title：Cell

authors： Shum WW,Da Silva N,McKee M,Smith PJ,Brown D,Breton S

更新日期：2008-12-12 00:00:00

abstract：:Epidermal lineage commitment occurs when multipotent stem cells are specified to three lineages: the epidermis, the hair follicle, and the sebaceous gland (SG). How and when a lineage becomes specified remains unknown. Here, we report the existence of a population of unipotent progenitor cells that reside in the SG an...

journal_title：Cell

authors： Horsley V,O'Carroll D,Tooze R,Ohinata Y,Saitou M,Obukhanych T,Nussenzweig M,Tarakhovsky A,Fuchs E

更新日期：2006-08-11 00:00:00

abstract：:To reconstruct modern human evolutionary history and identify loci that have shaped hunter-gatherer adaptation, we sequenced the whole genomes of five individuals in each of three different hunter-gatherer populations at > 60× coverage: Pygmies from Cameroon and Khoesan-speaking Hadza and Sandawe from Tanzania. We ide...

journal_title：Cell

authors： Lachance J,Vernot B,Elbers CC,Ferwerda B,Froment A,Bodo JM,Lema G,Fu W,Nyambo TB,Rebbeck TR,Zhang K,Akey JM,Tishkoff SA

更新日期：2012-08-03 00:00:00

abstract：:Signaling by TGF beta-related factors requires ligand-induced association between type I and type II transmembrane serine/threonine kinases. In Drosophila, the saxophone (sax) and thick veins (tkv) genes encode type I receptors that mediate signaling by decapentaplegic (dpp), a member of the bone morphogenetic protein...

journal_title：Cell

authors： Letsou A,Arora K,Wrana JL,Simin K,Twombly V,Jamal J,Staehling-Hampton K,Hoffmann FM,Gelbart WM,Massagué J

更新日期：1995-03-24 00:00:00

abstract：:Histone methylation regulates chromatin structure and transcription. The recently identified histone demethylase lysine-specific demethylase 1 (LSD1) is chemically restricted to demethylation of only mono- and di- but not trimethylated histone H3 lysine 4 (H3K4me3). We show that the X-linked mental retardation (XLMR) ...

journal_title：Cell

authors： Iwase S,Lan F,Bayliss P,de la Torre-Ubieta L,Huarte M,Qi HH,Whetstine JR,Bonni A,Roberts TM,Shi Y

更新日期：2007-03-23 00:00:00

abstract：:The crystal structure of the snake toxin fasciculin, bound to mouse acetylcholinesterase (mAChE), at 3.2 A resolution reveals a synergistic three-point anchorage consistent with the picomolar dissociation constant of the complex. Loop II of fasciculin contains a cluster of hydrophobic residues that interact with the p...

journal_title：Cell

authors： Bourne Y,Taylor P,Marchot P

更新日期：1995-11-03 00:00:00

abstract：:Interactions between similar but not identical (homeologous) DNA sequences play an important biological role in the evolution of genes and genomes. To gain insight into the underlying molecular mechanism(s) of genetic recombination, we have studied inter- and intramolecular homeologous recombination in S. cerevisiae d...

journal_title：Cell

authors： Mézard C,Pompon D,Nicolas A

更新日期：1992-08-21 00:00:00

abstract：:Neurons in the cerebral cortex connect through descending pathways to hindbrain and spinal cord to activate muscle and generate movement. Although components of this pathway have been previously generated and studied in vitro, the assembly of this multi-synaptic circuit has not yet been achieved with human cells. Here...

journal_title：Cell

authors： Andersen J,Revah O,Miura Y,Thom N,Amin ND,Kelley KW,Singh M,Chen X,Thete MV,Walczak EM,Vogel H,Fan HC,Paşca SP

更新日期：2020-12-23 00:00:00

abstract：:The preprotein translocase of the outer membrane of mitochondria (TOM complex) facilitates the recognition, insertion, and translocation of nuclear-encoded mitochondrial preproteins. We have purified the TOM complex from Neurospora crassa and analyzed its composition and functional properties. The TOM complex contains...

journal_title：Cell

authors： Künkele KP,Heins S,Dembowski M,Nargang FE,Benz R,Thieffry M,Walz J,Lill R,Nussberger S,Neupert W

更新日期：1998-06-12 00:00:00

abstract：:We studied H1 gene expression in hybrids of Xenopus laevis (female) x Xenopus borealis (male) and saw paternal H1 synthesis in mid-blastulae, which indicates that the H1 genes are active by this stage. The behavior of the maternal store of H1 histone mRNA was studied in androgenetic haploids. In which all stored mRNA ...

journal_title：Cell

authors： Woodland HR,Flynn JM,Wyllie AJ

更新日期：1979-09-01 00:00:00

abstract：:The majority of the mRNA molecules in HeLa cells contain 1-2 residue(s) of m6Ap and one blocked, methylated 5' terminal "cap" structure. The hnRNA, which is longer than mRNA, contains both m6Ap and caps but 4-6 times as many m6Ap residues per chain. In addition, nuclear molecules contain T2 RNA ase-resistant, methyl-l...

journal_title：Cell

authors： Salditt-Georgieff M,Jelinek W,Darnell JE,Furuichi Y,Morgan M,Shatkin A

更新日期：1976-02-01 00:00:00

abstract：:Fertilized clam embryos synthesize several new cell-cycle-related proteins. The cloned cDNA and derived amino acid sequences of one of these, cyclin A, are presented here. Immunoblots with an anti-cyclin A antibody reveal that cyclin A is undetectable in oocytes, appears within 15 min of fertilization, and is destroye...

journal_title：Cell

authors： Swenson KI,Farrell KM,Ruderman JV

更新日期：1986-12-26 00:00:00

abstract：:We have cloned a Dictyostelium phosphotyrosine phosphatase (PTP1) with a catalytic domain showing approximately 38%-50% amino acid identity to those of other PTPs. PTP1 contains an approximately 99 amino acid insert and bacterially produced PTP1 possesses PTP activity. PTP1 is expressed at a very low level in vegetati...

journal_title：Cell

authors： Howard PK,Sefton BM,Firtel RA

更新日期：1992-11-13 00:00:00

abstract：:In this issue of Cell, a study by Valerie Mizrahi and her colleagues suggests that a putative error-prone DNA polymerase encoded by the dnaE2 gene of Mycobacterium tuberculosis may bypass certain types of DNA base damage, generating mutations. This may be an important mechanism for generating drug-resistant strains of...

journal_title：Cell

authors： Friedberg EC,Fischhaber PL

更新日期：2003-04-18 00:00:00

abstract：:The actions and receptor for ciliary neurotrophic factor (CNTF) are largely restricted to cells of the nervous system, although one of the CNTF receptor components, CNTFR alpha, is expressed by skeletal muscle. Here we show that the other CNTF receptor components, LIFR beta and gp130, are also expressed by skeletal mu...

journal_title：Cell

authors： Helgren ME,Squinto SP,Davis HL,Parry DJ,Boulton TG,Heck CS,Zhu Y,Yancopoulos GD,Lindsay RM,DiStefano PS

更新日期：1994-02-11 00:00:00

abstract：:Mammalian cells express a spectrum of tubulin isotypes whose relationship to the diversity of microtubule function is unknown. To examine whether different isotypes are segregated into functionally distinct microtubules, we generated immune sera capable of discriminating among the various naturally occurring beta-tubu...

journal_title：Cell

authors： Lewis SA,Gu W,Cowan NJ

更新日期：1987-05-22 00:00:00

abstract：:Recent biochemical and genetic studies indicate that in addition to the octamer-binding proteins Oct-1 and Oct-2, other B cell components are required for lymphoid-restricted, octamer site-mediated immunoglobulin gene promoter activity. Using a genetic screen in yeast, we have isolated B cell-derived cDNAs encoding Oc...

journal_title：Cell

authors： Strubin M,Newell JW,Matthias P

更新日期：1995-02-10 00:00:00

abstract：:Fractionation of a microsomal detergent extract with ammonium sulfate allows separation of the signal recognition particle receptor (SR alpha), which is required for targeting of the nascent chain, from other microsomal proteins, such as signal peptidase, whose activity is displayed during subsequent translocation. Th...

journal_title：Cell

authors： Nicchitta CV,Migliaccio G,Blobel G

更新日期：1991-05-17 00:00:00

abstract：:Polyglycylation is a posttranslational modification that generates glycine side chains on proteins. Here we identify a family of evolutionarily conserved glycine ligases that modify tubulin using different enzymatic mechanisms. In mammals, two distinct enzyme types catalyze the initiation and elongation steps of polyg...

journal_title：Cell

authors： Rogowski K,Juge F,van Dijk J,Wloga D,Strub JM,Levilliers N,Thomas D,Bré MH,Van Dorsselaer A,Gaertig J,Janke C

更新日期：2009-06-12 00:00:00

abstract：:Heat shock and other proteotoxic stresses cause accumulation of nonnative proteins that trigger activation of heat shock protein (Hsp) genes. A chaperone/Hsp functioning as repressor of heat shock transcription factor (HSF) could make activation of hsp genes dependent on protein unfolding. In a novel in vitro system, ...

journal_title：Cell

authors： Zou J,Guo Y,Guettouche T,Smith DF,Voellmy R

更新日期：1998-08-21 00:00:00

abstract：:This year's Lasker-Bloomberg Public Service Award goes to GAVI, the Vaccine Alliance, for providing sustained access to childhood vaccines around the globe, saving millions of lives, and highlighting the power of immunization to prevent disease. ...

journal_title：Cell

authors： Zerhouni E

更新日期：2019-09-19 00:00:00