Abstract:
:A mechanism by which the nerve growth factor (NGF) signal is transduced to the nucleus to induce gene expression has been characterized. An NGF-inducible, Ras-dependent protein kinase has been identified that catalyzes the phosphorylation of the cyclic AMP response element-binding protein (CREB) at Ser-133. Phosphorylation of Ser-133 stimulates the ability of CREB to activate transcription in NGF-treated cells. These findings suggest that CREB has a more widespread function than previously believed and functions in the nucleus as a general mediator of growth factor responses.
journal_name
Celljournal_title
Cellauthors
Ginty DD,Bonni A,Greenberg MEdoi
10.1016/0092-8674(94)90055-8subject
Has Abstractpub_date
1994-06-03 00:00:00pages
713-25issue
5eissn
0092-8674issn
1097-4172pii
0092-8674(94)90055-8journal_volume
77pub_type
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