Abstract：
:T lymphocyte selection and lineage commitment in the thymus requires multiple signals. Herein, CD4+ T cell generation required engagement of CD83, a surface molecule expressed by thymic epithelial and dendritic cells. CD83-deficient (CD83-/-) mice had a specific block in CD4+ single-positive thymocyte development without increased CD4+CD8+ double- or CD8+ single-positive thymocytes. This resulted in a selective 75%-90% reduction in peripheral CD4+ T cells, predominantly within the naive subset. Wild-type thymocytes and bone marrow stem cells failed to differentiate into mature CD4+ T cells when transferred into CD83-/- mice, while CD83-/- thymocytes and stem cells developed normally in wild-type mice. Thereby, CD83 expression represents an additional regulatory component for CD4+ T cell development in the thymus.
journal_name
Celljournal_title
Cellauthors
Fujimoto Y,Tu L,Miller AS,Bock C,Fujimoto M,Doyle C,Steeber DA,Tedder TFdoi
10.1016/s0092-8674(02)00673-6subject
Has Abstractpub_date
2002-03-22 00:00:00pages
755-67issue
6eissn
0092-8674issn
1097-4172pii
S0092867402006736journal_volume
108pub_type
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