Chicken myeloid stem cells infected by retroviruses carrying the v-fps oncogene do not require exogenous growth factors to differentiate in vitro.

abstract：:Vertebrate Hox genes are activated in a spatiotemporal sequence that reflects their clustered organization. While this colinear relationship is a property of most metazoans with an anterior to posterior polarity, the underlying molecular mechanisms are unknown. Previous work suggested that Hox genes were made progress...

journal_title：Cell

authors： Kondo T,Duboule D

更新日期：1999-04-30 00:00:00

abstract：:The phage Mu transpososome is assembled by interactions of transposase subunits with the left (L) and right (R) ends of Mu and an enhancer (E) located in between. A metastable three-site complex LER progresses into a more stable type 0 complex in which a tetrameric transposase is poised for DNA cleavage. "Difference t...

journal_title：Cell

authors： Pathania S,Jayaram M,Harshey RM

更新日期：2002-05-17 00:00:00

abstract：:How transcription is silenced in early embryos has long been a mystery. In this issue, Guven-Ozkan et al. (2008) report that transcriptional repression during worm embryogenesis is mediated through sequestration of the general transcription factor TAF-4 and is regulated by mechanisms that orchestrate the transition be...

journal_title：Cell

authors： Blackwell TK,Walker AK

更新日期：2008-10-03 00:00:00

abstract：:Peptide hormone fibroblast growth factor-21 (FGF21) has insulin-mimetic properties. Dutchak et al. now suggest that FGF21 also acts in an autocrine fashion in adipocytes and is required to mediate effects of the PPARγ agonist class of antidiabetic drugs. Does this new property improve FGF21's fledgling clinical prospe...

journal_title：Cell

authors： Qiang L,Accili D

更新日期：2012-02-03 00:00:00

abstract：:Ferroptosis is a form of regulated cell death characterized by the iron-dependent accumulation of lipid hydroperoxides to lethal levels. Emerging evidence suggests that ferroptosis represents an ancient vulnerability caused by the incorporation of polyunsaturated fatty acids into cellular membranes, and cells have dev...

journal_title：Cell

authors： Stockwell BR,Friedmann Angeli JP,Bayir H,Bush AI,Conrad M,Dixon SJ,Fulda S,Gascón S,Hatzios SK,Kagan VE,Noel K,Jiang X,Linkermann A,Murphy ME,Overholtzer M,Oyagi A,Pagnussat GC,Park J,Ran Q,Rosenfeld CS,Salnikow K

更新日期：2017-10-05 00:00:00

abstract：:In the developing nervous system, neural progenitors exit the cell cycle and differentiate on a precise schedule, yet the mechanisms driving this process remain poorly defined. Yan et al. (2009) now identify a thiol-redox reaction mediated by the membrane protein GDE2 and the peroxiredoxin protein Prdx1 that promotes ...

journal_title：Cell

authors： Novitch BG,Butler SJ

更新日期：2009-09-18 00:00:00

abstract：:The auditory inner hair cell (IHC) ribbon synapse operates with an exceptional temporal precision and maintains a high level of neurotransmitter release. However, the molecular mechanisms underlying IHC synaptic exocytosis are largely unknown. We studied otoferlin, a predicted C2-domain transmembrane protein, which is...

journal_title：Cell

authors： Roux I,Safieddine S,Nouvian R,Grati M,Simmler MC,Bahloul A,Perfettini I,Le Gall M,Rostaing P,Hamard G,Triller A,Avan P,Moser T,Petit C

更新日期：2006-10-20 00:00:00

abstract：:We have identified and analyzed a meiotic reciprocal recombination hot spot in S. cerevisiae. We find that double-strand breaks occur at two specific sites associated with the hot spot and that occurrence of these breaks depends upon meiotic recombination functions RAD50 and SPO11. Furthermore, these breaks occur in a...

journal_title：Cell

authors： Cao L,Alani E,Kleckner N

更新日期：1990-06-15 00:00:00

abstract：:Transfer RNAs (tRNAs) are primarily viewed as static contributors to gene expression. By developing a high-throughput tRNA profiling method, we find that specific tRNAs are upregulated in human breast cancer cells as they gain metastatic activity. Through loss-of-function, gain-of-function, and clinical-association st...

journal_title：Cell

authors： Goodarzi H,Nguyen HCB,Zhang S,Dill BD,Molina H,Tavazoie SF

更新日期：2016-06-02 00:00:00

abstract：:The cellular complexity and scale of the early liver have constrained analyses examining its emergence during organogenesis. To circumvent these issues, we analyzed 45,334 single-cell transcriptomes from embryonic day (E)7.5, when endoderm progenitors are specified, to E10.5 liver, when liver parenchymal and non-paren...

journal_title：Cell

authors： Lotto J,Drissler S,Cullum R,Wei W,Setty M,Bell EM,Boutet SC,Nowotschin S,Kuo YY,Garg V,Pe'er D,Church DM,Hadjantonakis AK,Hoodless PA

更新日期：2020-10-29 00:00:00

abstract：:Rapid flow of information in the nervous system involves presynaptic vesicle recycling by clathrin-mediated endocytosis, an event triggered by the alpha-adaptin-containing AP2 complex. We identified a Drosophila alpha-adaptin expressed in the garland cells, imaginal discs, and the CNS. Here we show its role in presyna...

journal_title：Cell

authors： González-Gaitán M,Jäckle H

更新日期：1997-03-21 00:00:00

abstract：:The tra-1 gene plays a central role in C. elegans sex determination. XX animals develop as hermaphrodites when tra-1 is active and as males when it is not. By analyzing a large number of tra-1 genetic mosaics we have shown that, with the expected exception of vulval induction by the hermaphrodite gonad, tra-1 function...

journal_title：Cell

authors： Hunter CP,Wood WB

更新日期：1990-12-21 00:00:00

abstract：:We present evidence that the genes encoding U3 snRNA in plants are transcribed by RNA polymerase III (pol III) and not by RNA polymerase II (pol II) as in vertebrates or lower eukaryotes. The U3 gene is the only known example of a gene transcribed by different polymerases in different organisms. It is possible to conv...

journal_title：Cell

authors： Kiss T,Marshallsay C,Filipowicz W

更新日期：1991-05-03 00:00:00

abstract：:Misfolded proteins accumulating in several neurodegenerative diseases (including Alzheimer, Parkinson, and Huntington diseases) can cause aggregation of their native counterparts through a mechanism similar to the infectious prion protein's induction of a pathogenic conformation onto its cellular isoform. Evidence for...

journal_title：Cell

authors： Polymenidou M,Cleveland DW

更新日期：2011-10-28 00:00:00

abstract：:Herpes simplex virus type 1 (HSV-1) binds to cells through interactions of viral glycoproteins gB and gC with heparan sulfate chains on cell surface proteoglycans. This binding is not sufficient for viral entry, which requires fusion between the viral envelope and cell membrane. Here, we show that heparan sulfate modi...

journal_title：Cell

authors： Shukla D,Liu J,Blaiklock P,Shworak NW,Bai X,Esko JD,Cohen GH,Eisenberg RJ,Rosenberg RD,Spear PG

更新日期：1999-10-01 00:00:00

abstract：:We examined the interactions of lipid vesicles (liposomes) labeled with various fluorescent markers with the intracellular membranes of semi-intact ("perforated") fibroblasts. When incubations were performed in the presence of an ATP-regenerating system, both vesicle lipids and entrapped water soluble markers were tra...

journal_title：Cell

authors： Kobayashi T,Pagano RE

更新日期：1988-12-02 00:00:00

abstract：:Transfection experiments with HSV 1 in which one uses herpes simplex virus (HSV) thymidine kinase (TK) as a selectable prototrophic marker yield two classes of transformed cells: stable and unstable. In this report, we test the hypothesis that the stability phenotype can be explained by virus genome integration into a...

journal_title：Cell

authors： Smiley JR,Steege DA,Juricek DK,Summers WP,Ruddle FH

更新日期：1978-10-01 00:00:00

abstract：:The 2013-2015 West African epidemic of Ebola virus disease (EVD) reminds us of how little is known about biosafety level 4 viruses. Like Ebola virus, Lassa virus (LASV) can cause hemorrhagic fever with high case fatality rates. We generated a genomic catalog of almost 200 LASV sequences from clinical and rodent reserv...

journal_title：Cell

authors： Andersen KG,Shapiro BJ,Matranga CB,Sealfon R,Lin AE,Moses LM,Folarin OA,Goba A,Odia I,Ehiane PE,Momoh M,England EM,Winnicki S,Branco LM,Gire SK,Phelan E,Tariyal R,Tewhey R,Omoniwa O,Fullah M,Fonnie R,Fonnie M,

更新日期：2015-08-13 00:00:00

abstract：:The mitotic checkpoint prevents advance to anaphase prior to successful attachment of every centromere/kinetochore to mitotic spindle microtubules. Using purified components and Xenopus egg extracts, the kinetochore-associated microtubule motor CENP-E is now shown to be the activator of the essential checkpoint kinase...

journal_title：Cell

authors： Mao Y,Abrieu A,Cleveland DW

更新日期：2003-07-11 00:00:00

abstract：:The fasciclin I, II, and III glycoproteins are expressed on different subsets of axon bundles (fascicles) in insect embryos and are thus candidates for surface recognition molecules involved in growth cone guidance. Here we present the sequence of grasshopper fasciclin I and the identification and sequence of the Dros...

journal_title：Cell

authors： Zinn K,McAllister L,Goodman CS

更新日期：1988-05-20 00:00:00

abstract：:Microbial populations can maximize fitness in dynamic environments through bet hedging, a process wherein a subpopulation assumes a phenotype not optimally adapted to the present environment but well adapted to an environment likely to be encountered. Here, we show that oxygen induces fluctuating expression of the tri...

journal_title：Cell

authors： Carey JN,Mettert EL,Roggiani M,Myers KS,Kiley PJ,Goulian M

更新日期：2018-03-22 00:00:00

abstract：:The hemagglutinin of influenza virus is synthesized as a monomeric subunit that is cotranslationally translocated across the membrane of the rough endoplasmic reticulum. We show that folding and assembly of hemagglutinin monomers into trimeric structures takes approximately 7-10 min and is completed before the protein...

journal_title：Cell

authors： Gething MJ,McCammon K,Sambrook J

更新日期：1986-09-12 00:00:00

abstract：:During Tetrahymena conjugation, programmed DNA degradation occurs in two separate nuclei. Thousands of germline-specific deletion elements are removed from the genome of the developing somatic macronucleus, and the old parental macronucleus is degraded by an apoptotic mechanism. An abundant polypeptide, Pdd1p (formerl...

journal_title：Cell

authors： Madireddi MT,Coyne RS,Smothers JF,Mickey KM,Yao MC,Allis CD

更新日期：1996-10-04 00:00:00

abstract：:Dysregulation of splicing and alternative splicing underlies many genetic and acquired diseases. We present an overview of recent strategies and successes in modulating splicing therapeutically in clinical and preclinical contexts. Effective approaches include restoring open reading frames, influencing alternative spl...

journal_title：Cell

authors： Spitali P,Aartsma-Rus A

更新日期：2012-03-16 00:00:00

abstract：:SecA, the peripheral subunit of E. coli preprotein translocase, alternates between a membrane inserted and a deinserted state as part of the catalytic cycle of preprotein translocation. When SecA is complexed with SecY/E and preprotein, ATP drives a profound conformational change, leading to membrane insertion of a 30...

journal_title：Cell

authors： Economou A,Wickner W

更新日期：1994-09-09 00:00:00

abstract：:T cells expressing chimeric antigen receptors (CARs) are promising cancer therapeutic agents, with the prospect of becoming the ultimate smart cancer therapeutics. To expand the capability of CAR T cells, here, we present a split, universal, and programmable (SUPRA) CAR system that simultaneously encompasses multiple ...

journal_title：Cell

authors： Cho JH,Collins JJ,Wong WW

更新日期：2018-05-31 00:00:00

abstract：:The initiation of chromosome segregation at anaphase is linked by the spindle assembly checkpoint to the completion of chromosome-microtubule attachment during metaphase. To determine the function of the mitotic checkpoint protein Mad2 during normal cell division and when mitosis goes awry, we have knocked out Mad2 in...

journal_title：Cell

authors： Dobles M,Liberal V,Scott ML,Benezra R,Sorger PK

更新日期：2000-06-09 00:00:00

abstract：:Homologous recombination in embryonal stem cells has been used to produce a fusion oncogene, thereby mimicking chromosomal translocations that frequently result in formation of tumor-specific fusion oncogenes in human malignancies. AF9 sequences were fused into the mouse Mll gene so that expression of the Mll-AF9 fusi...

journal_title：Cell

authors： Corral J,Lavenir I,Impey H,Warren AJ,Forster A,Larson TA,Bell S,McKenzie AN,King G,Rabbitts TH

更新日期：1996-06-14 00:00:00

abstract：:Mutations in the Drosophila maternal genes plutonium (plu) and pan gu (png) have the striking phenotype that DNA replication initiates in unfertilized eggs. Fertilized eggs from plu or png mutant mothers also have a mutant phenotype; DNA replication is uncoupled from nuclear division, resulting in giant, polyploid nuc...

journal_title：Cell

authors： Shamanski FL,Orr-Weaver TL

更新日期：1991-09-20 00:00:00

abstract：:Ethylene regulates many aspects of plant growth and development. In the presence of ethylene, the C terminus of EIN2 (EIN2C) translocates into the nucleus and activates transcription. Li et al. and Merchante et al. show that EIN2C also regulates translation through an interaction with the 3' UTRs of transcripts. ...

journal_title：Cell

authors： Salehin M,Estelle M

更新日期：2015-10-22 00:00:00