Pulling back to move forward.

abstract：:Anterograde transport in the early secretory pathway is mediated by COPII-coated vesicles. Stagg et al. (2008) have now visualized the double-layered COPII coat using electron cryomicroscopy, providing insight into how coats are assembled to accommodate cargo of different sizes. ...

journal_title：Cell

authors： Hughson FM

更新日期：2008-08-08 00:00:00

abstract：:The transmission of information across neuronal synapses is an energetically taxing business. Sheng and colleagues monitored the localization of mitochondria following different levels of synaptic activation and discovered that these organelles change their distribution in interesting ways, stalling near synapses when...

journal_title：Cell

authors： Schuman E,Chan D

更新日期：2004-12-17 00:00:00

abstract：:The mechanism by which cells decide to skip mitosis to become polyploid is largely undefined. Here we used a high-content image-based screen to identify small-molecule probes that induce polyploidization of megakaryocytic leukemia cells and serve as perturbagens to help understand this process. Our study implicates fi...

journal_title：Cell

authors： Wen Q,Goldenson B,Silver SJ,Schenone M,Dancik V,Huang Z,Wang LZ,Lewis TA,An WF,Li X,Bray MA,Thiollier C,Diebold L,Gilles L,Vokes MS,Moore CB,Bliss-Moreau M,Verplank L,Tolliday NJ,Mishra R,Vemula S,Shi J,Wei L

更新日期：2012-08-03 00:00:00

abstract：:DNA repair was measured in the dihydrofolate reductase gene in Chinese hamster ovary cells, amplified for the gene, by quantitating pyrimidine dimers with a specific UV-endonuclease. More than two thirds of the dimers had been removed from a 14.1 kb restriction fragment of the gene by 26 hr after irradiation (20 J/m2)...

journal_title：Cell

authors： Bohr VA,Smith CA,Okumoto DS,Hanawalt PC

更新日期：1985-02-01 00:00:00

abstract：:The origin recognition complex (ORC) is required to initiate eukaryotic DNA replication and also engages in transcriptional silencing in S. cerevisiae. We observed a striking preferential but not exclusive association of Drosophila ORC2 with heterochromatin on interphase and mitotic chromosomes. HP1, a heterochromatin...

journal_title：Cell

authors： Pak DT,Pflumm M,Chesnokov I,Huang DW,Kellum R,Marr J,Romanowski P,Botchan MR

更新日期：1997-10-31 00:00:00

abstract：:The chaperonin GroEL binds nonnative proteins too large to fit inside the productive GroEL-GroES cis cavity, but whether and how it assists their folding has remained unanswered. We have examined yeast mitochondrial aconitase, an 82 kDa monomeric Fe(4)S(4) cluster-containing enzyme, observed to aggregate in chaperonin...

journal_title：Cell

authors： Chaudhuri TK,Farr GW,Fenton WA,Rospert S,Horwich AL

更新日期：2001-10-19 00:00:00

abstract：:The stomata of plants regulate gas exchange and water transpiration in response to changing environmental conditions. New work reveals that stomata also have an important role in host defense. In this issue of Cell, Melotto et al. (2006) show that stomata close upon detection of potential microbial pathogens to preven...

journal_title：Cell

authors： Schulze-Lefert P,Robatzek S

更新日期：2006-09-08 00:00:00

abstract：:Pure primary mesenchymal cells from definitive streak stage chick embryos have been prepared free of epiblast and hypoblast cells. These cells have the potential in culture to differentiate into erythroid cells, beating heart muscle tissue, chondrocytes and epithelial cells. Transformation in vitro of pure primary mes...

journal_title：Cell

authors： Keane RW,Lindblad PC,Pierik LT,Ingram VM

更新日期：1979-08-01 00:00:00

abstract：:Epidermal lineage commitment occurs when multipotent stem cells are specified to three lineages: the epidermis, the hair follicle, and the sebaceous gland (SG). How and when a lineage becomes specified remains unknown. Here, we report the existence of a population of unipotent progenitor cells that reside in the SG an...

journal_title：Cell

authors： Horsley V,O'Carroll D,Tooze R,Ohinata Y,Saitou M,Obukhanych T,Nussenzweig M,Tarakhovsky A,Fuchs E

更新日期：2006-08-11 00:00:00

abstract：:From a transplantable mouse teratoma it has been possible to derive an established keratinizing cell line (XB) which grows well in cultures containing lethally irradiated 3T3 fibroblasts at the correct density. Single cells of the keratinizing line grow into colonies each consisting of a stratified squamous epithelium...

journal_title：Cell

authors： Rheinwald JG,Green H

更新日期：1975-11-01 00:00:00

abstract：:MicroRNAs are small endogenous noncoding RNAs involved in posttranscriptional gene regulation. During microRNA biogenesis, Drosha and Dicer process the primary transcript (pri-miRNA) through a precursor hairpin (pre-miRNA) to the mature miRNA. The miRNA is incorporated into the RNA-Induced Silencing Complex (RISC) wit...

journal_title：Cell

authors： Diederichs S,Haber DA

更新日期：2007-12-14 00:00:00

abstract：:Antibodies to DNA and chromatin drive autoimmunity in systemic lupus erythematosus (SLE). Null mutations and hypomorphic variants of the secreted deoxyribonuclease DNASE1L3 are linked to familial and sporadic SLE, respectively. We report that DNASE1L3-deficient mice rapidly develop autoantibodies to DNA and chromatin,...

journal_title：Cell

authors： Sisirak V,Sally B,D'Agati V,Martinez-Ortiz W,Özçakar ZB,David J,Rashidfarrokhi A,Yeste A,Panea C,Chida AS,Bogunovic M,Ivanov II,Quintana FJ,Sanz I,Elkon KB,Tekin M,Yalçınkaya F,Cardozo TJ,Clancy RM,Buyon JP,Reizis

更新日期：2016-06-30 00:00:00

abstract：:Mutations at the X-linked disconnected locus of D. melanogaster lead to the failure of adult photoreceptor axons to innervate their target cells in the developing optic lobes of the third instar larva, resulting in flies that have rudimentary optic ganglia. The cascade of epigenetic events leading to the adult disconn...

journal_title：Cell

authors： Steller H,Fischbach KF,Rubin GM

更新日期：1987-09-25 00:00:00

abstract：:Two DNA sequences that reduce mitotic fidelity of chromosome transmission have been identified: MIF1 and MIF2. MIF1 is a unique sequence located on the right arm of chromosome XII that stimulates loss and recombination for both chromosomes V and VII when present in a high copy number plasmid. MIF1 is not essential for...

journal_title：Cell

authors： Meeks-Wagner D,Wood JS,Garvik B,Hartwell LH

更新日期：1986-01-17 00:00:00

abstract：:How difficult is to go from egg to implanted embryo? The evolution of placentation in eutherian mammals created enormous challenges, in particular to the maternal immune system, as the fetus expresses paternal antigens that are capable of triggering immune rejection. Samstein et al. reveal a role for inducible regulat...

journal_title：Cell

authors： Gobert M,Lafaille JJ

更新日期：2012-07-06 00:00:00

abstract：:Dominantly inherited mutations in an endoplasmic reticulum protein called VAPB have been found in a subset of patients with a rare familial form of amyotrophic lateral sclerosis (ALS). In this issue, Tsuda et al. (2008) identify a secreted form of VAPB that binds directly to Eph receptors inducing their activation and...

journal_title：Cell

authors： Ackerman SL,Cox GA

更新日期：2008-06-13 00:00:00

abstract：:Septate and tight junctions are thought to seal neighboring cells together and to function as barriers between epithelial cells. We have characterized a novel member of the neurexin family, Neurexin IV (NRX), which is localized to septate junctions (SJs) of epithelial and glial cells. NRX is a transmembrane protein wi...

journal_title：Cell

authors： Baumgartner S,Littleton JT,Broadie K,Bhat MA,Harbecke R,Lengyel JA,Chiquet-Ehrismann R,Prokop A,Bellen HJ

更新日期：1996-12-13 00:00:00

abstract：:Nerve regeneration and developmental outgrowth of axons are both correlated with increased synthesis of an axonal membrane protein designated GAP-43. Phosphorylation of an apparently identical protein, present at lower abundance in adult brains, has been correlated with long-term potentiation, a form of synaptic plast...

journal_title：Cell

authors： Basi GS,Jacobson RD,Virág I,Schilling J,Skene JH

更新日期：1987-06-19 00:00:00

abstract：:The dentate gyrus of the mammalian hippocampus continuously generates new neurons during adulthood. These adult-born neurons become functionally active and are thought to contribute to learning and memory, especially during their maturation phase, when they have extraordinary plasticity. In this Review, we discuss the...

journal_title：Cell

authors： Gonçalves JT,Schafer ST,Gage FH

更新日期：2016-11-03 00:00:00

abstract：:Vg1 is a TGF beta-related growth factor encoded by a maternal mRNA localized to vegetal blastomeres in Xenopus embryos. Vg1 precursor protein is abundant in vegetal cells, but the processed mature form has not been readily detected and no activity has been demonstrated for the putative Vg1 mature protein. We have engi...

journal_title：Cell

authors： Thomsen GH,Melton DA

更新日期：1993-08-13 00:00:00

abstract：:Transcriptional silencing is a phenomenon in which the transcription of a gene by RNA polymerase II or III is repressed or not, dependent only on the gene's chromosomal location. Two prevailing models exist for silencing: (1) steric hindrance in silenced chromatin inhibits the binding of upstream activator proteins or...

journal_title：Cell

authors： Chen L,Widom J

更新日期：2005-01-14 00:00:00

abstract：:Clonal derivatives of C3HMT murine mammary cell lines in culture demonstrate conversion of mammary tumor virus (MMTV) expression at a rate of appriximately 6 per 100 clones. This alteration is largely unidirectional from a relatively high level (MMTV(H)) to a 10 fold lower level (MMTV(L)). This high rate of MMTV(L) va...

journal_title：Cell

authors： Parks WP,Hubbell ES,Goldberg RJ,O'Neill FJ,Scolnick EM

更新日期：1976-05-01 00:00:00

abstract：:The V(D)J recombinase subunits Rag-1 and Rag-2 mediate assembly of antigen receptor gene segments. We studied the mechanisms of DNA recognition by Rag-1/Rag-2 using surface plasmon resonance. The critical step for signal recognition is binding of Rag-1 to the nonamer. This is achieved by a region of Rag-1 homologous t...

journal_title：Cell

authors： Spanopoulou E,Zaitseva F,Wang FH,Santagata S,Baltimore D,Panayotou G

更新日期：1996-10-18 00:00:00

abstract：:Molecular codes, like postal zip codes, are generally considered a robust way to ensure the specificity of neuronal target selection. However, a code capable of unambiguously generating complex neural circuits is difficult to conceive. Here, we re-examine the notion of molecular codes in the light of developmental alg...

journal_title：Cell

authors： Hassan BA,Hiesinger PR

更新日期：2015-10-08 00:00:00

abstract：:Filamentous invasive growth of S. cerevisiae requires multiple elements of the mitogen-activated protein kinase (MAPK) signaling cascade that are also components of the mating pheromone response pathway. Here we show that, despite sharing several constituents, the two pathways use different MAP kinases. The Fus3 MAPK ...

journal_title：Cell

authors： Madhani HD,Styles CA,Fink GR

更新日期：1997-11-28 00:00:00

abstract：:TET-mediated 5-methyl cytosine (5mC) oxidation acts in epigenetic regulation, stem cell development, and cancer. Hu et al. now determine the crystal structure of the TET2 catalytic domain bound to DNA, shedding light on 5mC-DNA substrate recognition and the catalytic mechanism of 5mC oxidation. ...

journal_title：Cell

authors： Tsai CL,Tainer JA

更新日期：2013-12-19 00:00:00

abstract：:Transcriptional pausing by multisubunit RNA polymerases (RNAPs) is a key mechanism for regulating gene expression in both prokaryotes and eukaryotes and is a prerequisite for transcription termination. Pausing and termination states are thought to arise through a common, elemental pause state that is inhibitory for nu...

journal_title：Cell

authors： Weixlbaumer A,Leon K,Landick R,Darst SA

更新日期：2013-01-31 00:00:00

abstract：:The hsp 70 gene of Drosophila contains three domains to which a heat shock gene specific transcription factor (HSTF) binds. In addition to the previously described 55 bp binding domain proximal to the TAT homology, there are two 25 bp binding sites farther upstream. Footprinting studies with 5' and 3' deletion mutatio...

journal_title：Cell

authors： Topol J,Ruden DM,Parker CS

更新日期：1985-09-01 00:00:00

abstract：:Immune responses involve coordination across cell types and tissues. However, studies in cancer immunotherapy have focused heavily on local immune responses in the tumor microenvironment. To investigate immune activity more broadly, we performed an organism-wide study in genetically engineered cancer models using mass...

journal_title：Cell

authors： Spitzer MH,Carmi Y,Reticker-Flynn NE,Kwek SS,Madhireddy D,Martins MM,Gherardini PF,Prestwood TR,Chabon J,Bendall SC,Fong L,Nolan GP,Engleman EG

更新日期：2017-01-26 00:00:00

abstract：:The mechanisms by which immune checkpoint blockade modulates tumor evolution during therapy are unclear. We assessed genomic changes in tumors from 68 patients with advanced melanoma, who progressed on ipilimumab or were ipilimumab-naive, before and after nivolumab initiation (CA209-038 study). Tumors were analyzed by...

journal_title：Cell

authors： Riaz N,Havel JJ,Makarov V,Desrichard A,Urba WJ,Sims JS,Hodi FS,Martín-Algarra S,Mandal R,Sharfman WH,Bhatia S,Hwu WJ,Gajewski TF,Slingluff CL Jr,Chowell D,Kendall SM,Chang H,Shah R,Kuo F,Morris LGT,Sidhom JW,Sch

更新日期：2017-11-02 00:00:00