Scrambled ribosomal RNA gene pieces in Chlamydomonas reinhardtii mitochondrial DNA.

abstract：:The alpha IIb beta 3 integrin binds Arg-Gly-Asp-containing (RGD-containing) ligands in a cation-dependent interaction. A fourteen amino acid sequence, beta 3 (118-131), and an antibody to it, inhibited ligand binding functions of alpha IIb beta 3, and a 1:1 stoichiometric beta 3 (118-131)-RGD complex was detected by m...

journal_title：Cell

authors： D'Souza SE,Haas TA,Piotrowicz RS,Byers-Ward V,McGrath DE,Soule HR,Cierniewski C,Plow EF,Smith JW

更新日期：1994-11-18 00:00:00

abstract：:The fluid-mosaic model posits a liquid-like plasma membrane, which can flow in response to tension gradients. It is widely assumed that membrane flow transmits local changes in membrane tension across the cell in milliseconds, mediating long-range signaling. Here, we show that propagation of membrane tension occurs qu...

journal_title：Cell

authors： Shi Z,Graber ZT,Baumgart T,Stone HA,Cohen AE

更新日期：2018-12-13 00:00:00

abstract：:p53 is a key tumor suppressor protein that has numerous functions. Its primary mode of action has generally been ascribed to the induction of cell-cycle arrest, apoptosis, or senescence upon stress. Li et al. challenge this dogma with evidence that all three of these programs are dispensable for p53's tumor suppressiv...

journal_title：Cell

authors： Hock AK,Vousden KH

更新日期：2012-06-08 00:00:00

abstract：:In embryos of X. laevis, and many other species, early development requires targeted movements of molecules and molecular aggregates within the oocyte or egg cytoplasm. One well-known example in Xenopus is the aggregation of germ plasm, a group of cytoplasmic islands that become distributed during the first few cell c...

journal_title：Cell

authors： Robb DL,Heasman J,Raats J,Wylie C

更新日期：1996-11-29 00:00:00

abstract：:Academic travel has a substantial carbon footprint. The ongoing pandemic has propelled the development and adoption of technologies for online delivery of seminars and remote attendance at scientific conferences. This should not lead to the complete elimination of in-person events, but the scientific community must se...

journal_title：Cell

authors： Geitmann A

更新日期：2020-08-20 00:00:00

abstract：:Cellular receptors are required for efficient entry of retroviruses into cells. We previously cloned a chicken gene responsible for susceptibility to the retrovirus subgroup A Rous sarcoma virus (RSV(A)). Here we have isolated the quail homolog and generated two alternatively spliced processed genes encoding cellular ...

journal_title：Cell

authors： Bates P,Young JA,Varmus HE

更新日期：1993-09-24 00:00:00

abstract：:Coordinated organ behavior is crucial for an effective response to environmental stimuli. By studying regeneration of hair follicles in response to patterned hair plucking, we demonstrate that organ-level quorum sensing allows coordinated responses to skin injury. Plucking hair at different densities leads to a regene...

journal_title：Cell

authors： Chen CC,Wang L,Plikus MV,Jiang TX,Murray PJ,Ramos R,Guerrero-Juarez CF,Hughes MW,Lee OK,Shi S,Widelitz RB,Lander AD,Chuong CM

更新日期：2015-04-09 00:00:00

abstract：:We mutated, by gene targeting, the endogenous hypoxanthine phosphoribosyl transferase (HPRT) gene in mouse embryo-derived stem (ES) cells. A specialized construct of the neomycin resistance (neor) gene was introduced into an exon of a cloned fragment of the Hprt gene and used to transfect ES cells. Among the G418r col...

journal_title：Cell

authors： Thomas KR,Capecchi MR

更新日期：1987-11-06 00:00:00

abstract：:Basal cells are by definition located on the basolateral side of several epithelia, and they have never been observed reaching the lumen. Using high-resolution 3D confocal imaging, we report that basal cells extend long and slender cytoplasmic projections that not only reach toward the lumen but can cross the tight ju...

journal_title：Cell

authors： Shum WW,Da Silva N,McKee M,Smith PJ,Brown D,Breton S

更新日期：2008-12-12 00:00:00

abstract：:New biological tools provide new techniques to probe fundamental biological processes. Here we describe the burgeoning field of proteolysis-targeting chimeras (PROTACs), which are capable of modulating protein concentrations at a post-translational level by co-opting the ubiquitin-proteasome system. We describe the PR...

journal_title：Cell

authors： Burslem GM,Crews CM

更新日期：2020-04-02 00:00:00

abstract：:In nearly every organism studied, reduced caloric intake extends life span. In yeast, span extension from dietary restriction is thought to be mediated by the highly conserved, nutrient-responsive target of rapamycin (TOR), protein kinase A (PKA), and Sch9 kinases. These kinases coordinately regulate various cellular ...

journal_title：Cell

authors： Steffen KK,MacKay VL,Kerr EO,Tsuchiya M,Hu D,Fox LA,Dang N,Johnston ED,Oakes JA,Tchao BN,Pak DN,Fields S,Kennedy BK,Kaeberlein M

更新日期：2008-04-18 00:00:00

abstract：:During the early stage of Ad2 infection of human cells, RNA is transcribed from five separate transcription units. Early region II encodes the mRNA for a 72K single-stranded DNA binding protein (DBP) which functions in DNA replication. This report describes the structure of the first leader of the DBP mRNA and the fla...

journal_title：Cell

authors： Baker CC,Herisse J,Courtois G,Galibert F,Ziff E

更新日期：1979-10-01 00:00:00

abstract：:Protein phosphorylation and protein ubiquitination regulate most aspects of cell life, and defects in these control mechanisms cause cancer and many other diseases. In the past decade, protein kinases have become one of the most important classes of drug targets for the pharmaceutical industry. In contrast, drug disco...

journal_title：Cell

authors： Cohen P,Tcherpakov M

更新日期：2010-11-24 00:00:00

abstract：:Alternative splicing (AS) patterns have diverged rapidly during vertebrate evolution, yet the functions of most species- and lineage-specific splicing events are not known. We observe that mammalian-specific AS events are enriched in transcript sequences encoding intrinsically disordered regions (IDRs) of proteins, in...

journal_title：Cell

authors： Gueroussov S,Weatheritt RJ,O'Hanlon D,Lin ZY,Narula A,Gingras AC,Blencowe BJ

更新日期：2017-07-13 00:00:00

abstract：:To determine the function of c-fps in chicken macrophages and granulocytic cells we have infected chicken bone marrow cells with retroviruses containing the v-fps oncogene. Normal chicken macrophage progenitors, M-CFCs, give rise to macrophage colonies in semisolid cultures when macrophage colony stimulating factor (M...

journal_title：Cell

authors： Carmier JF,Samarut J

更新日期：1986-01-17 00:00:00

abstract：:Temperature compensation of circadian clocks is an unsolved problem with relevance to the general phenomenon of biological compensation. We identify casein kinase 2 (CK2) as a key regulator of temperature compensation of the Neurospora clock by determining that two long-standing clock mutants, chrono and period-3, dis...

journal_title：Cell

authors： Mehra A,Shi M,Baker CL,Colot HV,Loros JJ,Dunlap JC

更新日期：2009-05-15 00:00:00

abstract：:Upon exposure to 0.1 mM N-phosphonacetyl-L-aspartate (PALA), a transition state analog inhibitor of aspartate transcarbamylase, most cells of a simian virus 40 (SV40)-transformed Syrian hamster line are killed within a few days, but resistant mutants form spontaneously with frequency 2-5 X 10(-5) in a stochastic proce...

journal_title：Cell

authors： Kempe TD,Swyryd EA,Bruist M,Stark GR

更新日期：1976-12-01 00:00:00

abstract：:KRASG12C was recently identified to be potentially druggable by allele-specific covalent targeting of Cys-12 in vicinity to an inducible allosteric switch II pocket (S-IIP). Success of this approach requires active cycling of KRASG12C between its active-GTP and inactive-GDP conformations as accessibility of the S-IIP ...

journal_title：Cell

authors： Janes MR,Zhang J,Li LS,Hansen R,Peters U,Guo X,Chen Y,Babbar A,Firdaus SJ,Darjania L,Feng J,Chen JH,Li S,Li S,Long YO,Thach C,Liu Y,Zarieh A,Ely T,Kucharski JM,Kessler LV,Wu T,Yu K,Wang Y,Yao Y,Deng X,

更新日期：2018-01-25 00:00:00

abstract：:STAT6 plays a prominent role in adaptive immunity by transducing signals from extracellular cytokines. We now show that STAT6 is required for innate immune signaling in response to virus infection. Viruses or cytoplasmic nucleic acids trigger STING (also named MITA/ERIS) to recruit STAT6 to the endoplasmic reticulum, ...

journal_title：Cell

authors： Chen H,Sun H,You F,Sun W,Zhou X,Chen L,Yang J,Wang Y,Tang H,Guan Y,Xia W,Gu J,Ishikawa H,Gutman D,Barber G,Qin Z,Jiang Z

更新日期：2011-10-14 00:00:00

abstract：:The pair-rule segmentation gene hairy (h) is expressed and required in alternate metameres in the early Drosophila embryo. We show that h expression outside these domains, driven by an hsp70 promoter, suppresses the expression of fushi tarazu (ftz). The kinetics of action favor h acting directly as a transcriptional r...

journal_title：Cell

authors： Ish-Horowicz D,Pinchin SM

更新日期：1987-11-06 00:00:00

abstract：:The precursor of the 55K adenovirus terminal protein is an 87K protein that is covalently linked to viral DNA. This protein is likely to be identical to the 80,000 dalton protein described by Challberg et al. (1980). The mRNA for the 87K terminal protein precursor, like that for the E2-72K DNA binding protein, is dete...

journal_title：Cell

authors： Stillman BW,Lewis JB,Chow LT,Mathews MB,Smart JE

更新日期：1981-02-01 00:00:00

abstract：:We have prepared three monoclonal antibodies against human epidermal keratins. These antibodies were highly specific for keratins and, in combination, recognized all major epidermal keratins of several mammalian species. We have used these antibodies to study the tissue distribution of epidermis-related keratins. In v...

journal_title：Cell

authors： Tseng SC,Jarvinen MJ,Nelson WG,Huang JW,Woodcock-Mitchell J,Sun TT

更新日期：1982-09-01 00:00:00

abstract：:Transfer RNA (tRNA) gene content is a differentiating feature of genomes that contributes to the efficiency of the translational apparatus, but the principles shaping tRNA gene copy number and codon composition are poorly understood. Here, we report that the emergence of two specific tRNA modifications shaped the stru...

journal_title：Cell

authors： Novoa EM,Pavon-Eternod M,Pan T,Ribas de Pouplana L

更新日期：2012-03-30 00:00:00

abstract：:The quest to slow aging has come far, and what used to be the domain of science fiction writers and snake oil salesmen may soon become science fact. Innovative new approaches, such as the use of the very short-lived African killifish (Harel et al.), are bridging the translational gap and bring the promise of healthy l...

journal_title：Cell

authors： Wang AM,Promislow DEL,Kaeberlein M

更新日期：2015-02-26 00:00:00

abstract：:The Reelin ligand regulates a Dab1-dependent signaling pathway required for brain lamination and normal dendritogenesis, but the specific mechanisms underlying these actions remain unclear. We find that Stk25, a modifier of Reelin-Dab1 signaling, regulates Golgi morphology and neuronal polarization as part of an LKB1-...

journal_title：Cell

authors： Matsuki T,Matthews RT,Cooper JA,van der Brug MP,Cookson MR,Hardy JA,Olson EC,Howell BW

更新日期：2010-11-24 00:00:00

abstract：:The light-sensing organelle of the vertebrate rod photoreceptor, the outer segment (OS), is a modified cilium containing approximately 1,000 stacked disc membranes that are densely packed with visual pigment rhodopsin. The mammalian OS is renewed every ten days; new discs are assembled at the base of the OS by a poorl...

journal_title：Cell

authors： Chuang JZ,Zhao Y,Sung CH

更新日期：2007-08-10 00:00:00

abstract：:The nucleotide sequences of the 3' termini of the DNA from four autonomous rodent parvoviruses have been determined. The terminus of each genome exists as a Y-shaped hairpin structure involving 115 or 116 nucleotides. The sequence of this region of DNA is highly conserved and shows no evidence of internal sequence het...

journal_title：Cell

authors： Astell CR,Smith M,Chow MB,Ward DC

更新日期：1979-07-01 00:00:00

abstract：:Cell surface growth factor receptors couple environmental cues to the regulation of cytoplasmic homeostatic processes, including autophagy, and aberrant activation of such receptors is a common feature of human malignancies. Here, we defined the molecular basis by which the epidermal growth factor receptor (EGFR) tyro...

journal_title：Cell

authors： Wei Y,Zou Z,Becker N,Anderson M,Sumpter R,Xiao G,Kinch L,Koduru P,Christudass CS,Veltri RW,Grishin NV,Peyton M,Minna J,Bhagat G,Levine B

更新日期：2013-09-12 00:00:00

abstract：:Two studies from Jarosz et al. describe how [GAR(+)], a protein-based epigenetic determinant found mainly in wild yeast strains, can be activated by microbial cross-kingdom communication. With the aid of genetically and ecologically diverse bacteria, yeast can override an ancient regulatory mechanism of glucose repres...

journal_title：Cell

authors： Staniforth GL,Tuite MF

更新日期：2014-08-28 00:00:00

abstract：:In many cases the multiple genes coding for one specific tRNA are dispersed throughout the genome. The members of such a gene family nevertheless maintain a common nucleotide sequence during evolution. A major mechanism contributing to this concerted evolution is intergenic conversion. Here we show that it occurs betw...

journal_title：Cell

authors： Amstutz H,Munz P,Heyer WD,Leupoid U,Kohli J

更新日期：1985-04-01 00:00:00