Lymphangiogenesis: Molecular mechanisms and future promise.

abstract：:PTEN is a frequently mutated tumor suppressor gene that opposes the PI3K/AKT pathway through dephosphorylation of phosphoinositide-3,4,5-triphosphate. Recently, nuclear compartmentalization of PTEN was found as a key component of its tumor-suppressive activity; however its nuclear function remains poorly defined. Here...

journal_title：Cell

authors： Song MS,Carracedo A,Salmena L,Song SJ,Egia A,Malumbres M,Pandolfi PP

更新日期：2011-01-21 00:00:00

abstract：:Using positional cloning strategies, we have identified a CTG triplet repeat that undergoes expansion in myotonic dystrophy patients. This sequence is highly variable in the normal population. PCR analysis of the interval containing this repeat indicates that unaffected individuals have been 5 and 27 copies. Myotonic ...

journal_title：Cell

authors： Brook JD,McCurrach ME,Harley HG,Buckler AJ,Church D,Aburatani H,Hunter K,Stanton VP,Thirion JP,Hudson T

更新日期：1992-02-21 00:00:00

abstract：:Autophagy has been associated with both cell survival and cell death, but the role of autophagy in cell death has been controversial. In this issue, Berry and Baehrecke (2007) report that autophagy is involved in physiological cell death during Drosophila development and is controlled by similar mechanisms as those th...

journal_title：Cell

authors： Bergmann A

更新日期：2007-12-14 00:00:00

abstract：:The human invariant chain (I gamma) of class II histocompatibility antigens spans the membrane of the endoplasmic reticulum once. It exposes a small amino-terminal domain on the cytoplasmic side and a carboxy-terminal, glycosylated domain on the exoplasmic side of the membrane. When the exoplasmic domain of I gamma is...

journal_title：Cell

authors： Lipp J,Dobberstein B

更新日期：1986-09-26 00:00:00

abstract：:The protein product of the human Duchenne muscular dystrophy locus (DMD) and its mouse homolog (mDMD) have been identified by using polyclonal antibodies directed against fusion proteins containing two distinct regions of the mDMD cDNA. The DMD protein is shown to be approximately 400 kd and to represent approximately...

journal_title：Cell

authors： Hoffman EP,Brown RH Jr,Kunkel LM

更新日期：1987-12-24 00:00:00

abstract：:Bovine Papilloma Virus (BPV-1) establishes itself as a multicopy nuclear plasmid in somatic mammalian cells in culture. We report here that two discontinuous regions within the viral genome can independently support extrachromosomal replication of the Tn5 neomycinr gene in cells that provide viral factors in trans. Th...

journal_title：Cell

authors： Lusky M,Botchan MR

更新日期：1984-02-01 00:00:00

abstract：:Different species of fruit flies share habitats but are believed to mate with each other only rarely. In this issue, Fan et al. show that interspecies mating is inhibited by the taste receptor Gr32a (Gustatory receptor 32a) and a neural circuit in which it functions. ...

journal_title：Cell

authors： Koh TW,Carlson JR

更新日期：2013-07-03 00:00:00

abstract：:The expression of the E2A transcription unit of the adenovirus E1A deletion mutant dl312 in murine embryonal carcinoma (EC) stem cells suggests that they contain an activity that will complement viral E1A. We have prepared from these cells in vitro transcription extracts that use E1A-inducible promoters more efficient...

journal_title：Cell

authors： La Thangue NB,Rigby PW

更新日期：1987-05-22 00:00:00

abstract：:Use-dependent synapse remodeling is thought to provide a cellular mechanism for encoding durable memories, yet whether activity triggers an actual structural change has remained controversial. We use photoconductive stimulation to demonstrate activity-dependent morphological synaptic plasticity by video imaging of GFP...

journal_title：Cell

authors： Colicos MA,Collins BE,Sailor MJ,Goda Y

更新日期：2001-11-30 00:00:00

abstract：:We have cloned the C. elegans cell death gene ced-3. A ced-3 transcript is most abundant during embryogenesis, the stage during which most programmed cell deaths occur. The predicted CED-3 protein shows similarity to human and murine interleukin-1 beta-converting enzyme and to the product of the mouse nedd-2 gene, whi...

journal_title：Cell

authors： Yuan J,Shaham S,Ledoux S,Ellis HM,Horvitz HR

更新日期：1993-11-19 00:00:00

abstract：:A key aspect of genomic medicine is to make individualized clinical decisions from personal genomes. We developed a machine-learning framework to integrate personal genomes and electronic health record (EHR) data and used this framework to study abdominal aortic aneurysm (AAA), a prevalent irreversible cardiovascular ...

journal_title：Cell

authors： Li J,Pan C,Zhang S,Spin JM,Deng A,Leung LLK,Dalman RL,Tsao PS,Snyder M

更新日期：2018-09-06 00:00:00

abstract：:The organization of neuronal systems is often dependent on activity and competition between cells. In olfaction, the X-linked OCNC1 channel subunit is subject to random inactivation and is essential for odorant-evoked activity. Reporter-tagged OCNC1 mutant mice permit the visualization of OCNC1-deficient olfactory neu...

journal_title：Cell

authors： Zhao H,Reed RR

更新日期：2001-03-09 00:00:00

abstract：:At anaphase onset, the protease separase triggers chromosome segregation by cleaving the chromosomal cohesin complex. Here, we show that cohesin destruction in metaphase is sufficient for segregation of much of the budding yeast genome, but not of the long arm of chromosome XII that contains the rDNA repeats. rDNA in ...

journal_title：Cell

authors： Sullivan M,Higuchi T,Katis VL,Uhlmann F

更新日期：2004-05-14 00:00:00

abstract：:CD4 T cells potentiate the inflammatory or humoral immune response through the action of Th1 and Th2 cells, respectively. The molecular basis of the differentiation of these cells from naive T cell precursors is, however, unclear. We found that GATA-3 was selectively expressed in Th2 cells. GATA-3 is expressed at a hi...

journal_title：Cell

authors： Zheng W,Flavell RA

更新日期：1997-05-16 00:00:00

abstract：:The organization of mouse immunoglobulin heavy chain genes has been investigated by hybridization with cloned mu and alpha cDNA probes. Restriction endonuclease fragments bearing mu and alpha constant region genes and two types of variable region (VH) genes were compared in BALB/c embryos, liver and nine plasmacytomas...

journal_title：Cell

authors： Cory S,Adams JM

更新日期：1980-01-01 00:00:00

abstract：:A clone encoding PrP 27-30, the major protein in purified preparations of scrapie agent, was selected from a scrapie-infected hamster brain cDNA library by oligonucleotide probes corresponding to the N terminus of the protein. Southern blotting with PrP cDNA revealed a single gene with the same restriction patterns in...

journal_title：Cell

authors： Oesch B,Westaway D,Wälchli M,McKinley MP,Kent SB,Aebersold R,Barry RA,Tempst P,Teplow DB,Hood LE

更新日期：1985-04-01 00:00:00

abstract：:Mice homozygous for the recessive mutation swaying (sw) are characterized by ataxia and hypertonia, attributed to the malformation of anterior regions of the cerebellum. We show that sw is a deletion of a single base pair from the proto-oncogene Wnt-1. The deletion is predicted to cause premature termination of transl...

journal_title：Cell

authors： Thomas KR,Musci TS,Neumann PE,Capecchi MR

更新日期：1991-11-29 00:00:00

abstract：:Elements controlling tissue-specific expression of the rat albumin gene reside within roughly 150 bp upstream of the transcriptional initiation site. We show here by DNAase I footprinting assays that at least four distinct factors present in extracts derived from cells expressing albumin interact with these sequences....

journal_title：Cell

authors： Cereghini S,Raymondjean M,Carranca AG,Herbomel P,Yaniv M

更新日期：1987-08-14 00:00:00

abstract：:We have isolated five clones containing human histone genes from a human genomic DNA library, using a cloned X. laevis histone H4 cDNA probe (pX1ch4). Each genomic clone has been mapped and the locations of the histone genes have been determined by blot hybridization and hybridization-selection of human histone mRNA. ...

journal_title：Cell

authors： Heintz N,Zernik M,Roeder RG

更新日期：1981-06-01 00:00:00

abstract：:We are undertaking a genetic approach to investigate the role that synaptic modulation in the mammalian central nervous system plays in learning and memory and to identify relevant molecular components. We have generated mice deficient in the gamma isoform of protein kinase C (PKC gamma), an enzyme that has previously...

journal_title：Cell

authors： Abeliovich A,Paylor R,Chen C,Kim JJ,Wehner JM,Tonegawa S

更新日期：1993-12-31 00:00:00

abstract：:The hemagglutinin of influenza virus is synthesized as a monomeric subunit that is cotranslationally translocated across the membrane of the rough endoplasmic reticulum. We show that folding and assembly of hemagglutinin monomers into trimeric structures takes approximately 7-10 min and is completed before the protein...

journal_title：Cell

authors： Gething MJ,McCammon K,Sambrook J

更新日期：1986-09-12 00:00:00

abstract：:The Origin Recognition Complex (ORC) is a six-protein assembly that specifies the sites of DNA replication initiation in S. cerevisiae. Origin recognition by ORC requires ATP. Here, we demonstrate that two subunits, Orc1p and Orc5p, bind ATP and that Orc1p also hydrolyzes ATP. ATP binding and hydrolysis by Orc1p are b...

journal_title：Cell

authors： Klemm RD,Austin RJ,Bell SP

更新日期：1997-02-21 00:00:00

abstract：:Transfer of human chromosome 11, which contains the myoD locus, from primary fibroblasts into 10T1/2 cells results in activation of myoD. In contrast, hybrids that retain human chromosome 11 and additional human chromosomes fail to activate myoD. We show that human chromosome 4 inhibits myoD activation. myoD enhancer/...

journal_title：Cell

authors： Woloshin P,Song K,Degnin C,Killary AM,Goldhamer DJ,Sassoon D,Thayer MJ

更新日期：1995-08-25 00:00:00

abstract：:Uracil-DNA glycosylase inhibitor (Ugi) is a B. subtilis bacteriophage protein that protects the uracil-containing phage DNA by irreversibly inhibiting the key DNA repair enzyme uracil-DNA glycosylase (UDG). The 1.9 A crystal structure of Ugi complexed to human UDG reveals that the Ugi structure, consisting of a twiste...

journal_title：Cell

authors： Mol CD,Arvai AS,Sanderson RJ,Slupphaug G,Kavli B,Krokan HE,Mosbaugh DW,Tainer JA

更新日期：1995-09-08 00:00:00

abstract：:Wnt signaling plays a critical role in embryonic development, and genetic aberrations in this network have been broadly implicated in colorectal cancer. We find that the Wnt receptor Frizzled2 (Fzd2) and its ligands Wnt5a/b are elevated in metastatic liver, lung, colon, and breast cancer cell lines and in high-grade t...

journal_title：Cell

authors： Gujral TS,Chan M,Peshkin L,Sorger PK,Kirschner MW,MacBeath G

更新日期：2014-11-06 00:00:00

abstract：:Toxic DNA-protein crosslinks (DPCs) arise by ionizing irradiation and UV light, are particularly caused by endogenously produced reactive compounds such as formaldehyde, and also occur during compromised topoisomerase action. Although nucleotide excision repair and homologous recombination contribute to cell survival ...

journal_title：Cell

authors： Stingele J,Schwarz MS,Bloemeke N,Wolf PG,Jentsch S

更新日期：2014-07-17 00:00:00

abstract：:A recent series of papers, including Festa et al. (2011) in this issue, has revealed unexpected interdependent relationships among cell populations residing in and around the hair follicle. These interactions between different lineages of stem cells are crucial for hair follicle growth and cycling and point to a compl...

journal_title：Cell

authors： Jahoda CA,Christiano AM

更新日期：2011-09-02 00:00:00

abstract：:Chronic obstructive pulmonary disease (COPD) is one of the most common causes of death worldwide. We report in an emphysema model of mice chronically exposed to tobacco smoke that pulmonary vascular dysfunction, vascular remodeling, and pulmonary hypertension (PH) precede development of alveolar destruction. We provid...

journal_title：Cell

authors： Seimetz M,Parajuli N,Pichl A,Veit F,Kwapiszewska G,Weisel FC,Milger K,Egemnazarov B,Turowska A,Fuchs B,Nikam S,Roth M,Sydykov A,Medebach T,Klepetko W,Jaksch P,Dumitrascu R,Garn H,Voswinckel R,Kostin S,Seeger W,S

更新日期：2011-10-14 00:00:00

abstract：:Yeast chromosomes terminate in tracts of simple repetitive DNA (poly[G1-3T]). Mutations in the gene TEL1 result in shortened telomeres. Sequence analysis of TEL1 indicates that it encodes a very large (322 kDa) protein with amino acid motifs found in phosphatidylinositol/protein kinases. The closest homolog to TEL1 is...

journal_title：Cell

authors： Greenwell PW,Kronmal SL,Porter SE,Gassenhuber J,Obermaier B,Petes TD

更新日期：1995-09-08 00:00:00

abstract：:Viral pandemics, such as the one caused by SARS-CoV-2, pose an imminent threat to humanity. Because of its recent emergence, there is a paucity of information regarding viral behavior and host response following SARS-CoV-2 infection. Here we offer an in-depth analysis of the transcriptional response to SARS-CoV-2 comp...

journal_title：Cell

authors： Blanco-Melo D,Nilsson-Payant BE,Liu WC,Uhl S,Hoagland D,Møller R,Jordan TX,Oishi K,Panis M,Sachs D,Wang TT,Schwartz RE,Lim JK,Albrecht RA,tenOever BR

更新日期：2020-05-28 00:00:00