Abstract:
:We have isolated five clones containing human histone genes from a human genomic DNA library, using a cloned X. laevis histone H4 cDNA probe (pX1ch4). Each genomic clone has been mapped and the locations of the histone genes have been determined by blot hybridization and hybridization-selection of human histone mRNA. In contrast to the organization of previously characterized histone genes, the human histone genes are clustered in the genome but are not arranged into recognizable repeating units. The extreme lack of organization of the human histone genes may reflect the diminished requirement for rapid synthesis of large quantities of histone proteins during mammalian early development.
journal_name
Celljournal_title
Cellauthors
Heintz N,Zernik M,Roeder RGdoi
10.1016/0092-8674(81)90092-1subject
Has Abstractpub_date
1981-06-01 00:00:00pages
661-8issue
3eissn
0092-8674issn
1097-4172pii
0092-8674(81)90092-1journal_volume
24pub_type
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