Abstract：
:We present the first isolation of the terminal DNA of an intact Drosophila telomere. It differs from those isolated from other eukaryotes by the lack of short tandem repeats at the terminus. The terminal 14.5 kb is composed of four tandem elements derived from two families of non-long terminal repeat retrotransposons and is subject to slow terminal loss. One of these transposon families, TART (telomere-associated retrotransposon), is described for the first time here. The other element, HeT-A, has previously been shown to transpose to broken chromosome ends. Our results provide key evidence that these elements also transpose to natural chromosome ends. We propose that the telomere-associated repetitive DNA is maintained by saltatory expansions, including terminal transpositions of specialized retrotransposons, which serve to balance terminal loss.
journal_name
Celljournal_title
Cellauthors
Levis RW,Ganesan R,Houtchens K,Tolar LA,Sheen FMdoi
10.1016/0092-8674(93)90318-ksubject
Has Abstractpub_date
1993-12-17 00:00:00pages
1083-93issue
6eissn
0092-8674issn
1097-4172pii
0092-8674(93)90318-Kjournal_volume
75pub_type
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