当前位置： SCI文献检索 > CELL期刊下所有文献 > Circular Concatemers of Ultra-Short DNA Segments Produce Regulatory RNAs.

Circular Concatemers of Ultra-Short DNA Segments Produce Regulatory RNAs.

Abstract：

:In the ciliated protozoan Paramecium tetraurelia, Piwi-associated small RNAs are generated upon the elimination of tens of thousands of short transposon-derived DNA segments as part of development. These RNAs then target complementary DNA for elimination in a positive feedback process, contributing to germline defense and genome stability. In this work, we investigate the formation of these RNAs, which we show to be transcribed directly from the short (length mode 27 bp) excised DNA segments. Our data support a mechanism whereby the concatenation and circularization of excised DNA segments provides a template for RNA production. This process allows the generation of a double-stranded RNA for Dicer-like protein cleavage to give rise to a population of small regulatory RNAs that precisely match the excised DNA sequences. VIDEO ABSTRACT.

journal_name

Cell

journal_title

Cell

authors

Allen SE,Hug I,Pabian S,Rzeszutek I,Hoehener C,Nowacki M

doi

10.1016/j.cell.2017.02.020

subject

Has Abstract

pub_date

2017-03-09 00:00:00

pages

990-999.e7

issue

6

eissn

0092-8674

issn

1097-4172

pii

S0092-8674(17)30198-8

journal_volume

168

pub_type

杂志文章

相关文献

CELL文献大全
  • Primary, Adaptive, and Acquired Resistance to Cancer Immunotherapy.

    abstract：:Cancer immunotherapy can induce long lasting responses in patients with metastatic cancers of a wide range of histologies. Broadening the clinical applicability of these treatments requires an improved understanding of the mechanisms limiting cancer immunotherapy. The interactions between the immune system and cancer ...

    journal_title：Cell

    pub_type： 杂志文章,评审

    doi：10.1016/j.cell.2017.01.017

    authors： Sharma P,Hu-Lieskovan S,Wargo JA,Ribas A

    更新日期：2017-02-09 00:00:00

  • FGF21 and the second coming of PPARγ.

    abstract：:Peptide hormone fibroblast growth factor-21 (FGF21) has insulin-mimetic properties. Dutchak et al. now suggest that FGF21 also acts in an autocrine fashion in adipocytes and is required to mediate effects of the PPARγ agonist class of antidiabetic drugs. Does this new property improve FGF21's fledgling clinical prospe...

    journal_title：Cell

    pub_type： 评论,杂志文章

    doi：10.1016/j.cell.2012.01.020

    authors： Qiang L,Accili D

    更新日期：2012-02-03 00:00:00

  • Formation of a keratinizing epithelium in culture by a cloned cell line derived from a teratoma.

    abstract：:From a transplantable mouse teratoma it has been possible to derive an established keratinizing cell line (XB) which grows well in cultures containing lethally irradiated 3T3 fibroblasts at the correct density. Single cells of the keratinizing line grow into colonies each consisting of a stratified squamous epithelium...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/0092-8674(75)90183-x

    authors： Rheinwald JG,Green H

    更新日期：1975-11-01 00:00:00

  • Disruption of the Hoxd-13 gene induces localized heterochrony leading to mice with neotenic limbs.

    abstract：:Vertebrate Hoxd genes are sequentially activated during the morphogenesis and pattern formation of the limb. Using the approach of gene disruption via homologous recombination in embryonic stem cells, we have assessed the function of the last gene of the complex, Hoxd-13. Mutant mice displayed skeletal alterations alo...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/0092-8674(93)90378-4

    authors： Dollé P,Dierich A,LeMeur M,Schimmang T,Schuhbaur B,Chambon P,Duboule D

    更新日期：1993-11-05 00:00:00

  • Processed Vg1 protein is an axial mesoderm inducer in Xenopus.

    abstract：:Vg1 is a TGF beta-related growth factor encoded by a maternal mRNA localized to vegetal blastomeres in Xenopus embryos. Vg1 precursor protein is abundant in vegetal cells, but the processed mature form has not been readily detected and no activity has been demonstrated for the putative Vg1 mature protein. We have engi...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/0092-8674(93)80045-g

    authors： Thomsen GH,Melton DA

    更新日期：1993-08-13 00:00:00

  • Polycomb repression under the skin.

    abstract：:Polycomb group proteins control a hierarchy of gene expression during the differentiation of stem cells. In this issue, Ezhkova et al. (2009) show that repression mediated by Polycomb proteins controls the timing of differentiation of precursor cells of the epidermal lineage. ...

    journal_title：Cell

    pub_type： 评论,杂志文章

    doi：10.1016/j.cell.2009.03.004

    authors： Pirrotta V

    更新日期：2009-03-20 00:00:00

  • Mice lacking H2-M complexes, enigmatic elements of the MHC class II peptide-loading pathway.

    abstract：:We have generated mice lacking H2-M complexes, critical facilitators of peptide loading onto major histo-compatibility complex class II molecules. Ab molecules in these mice matured into stable complexes and were efficiently expressed at the cell surface. Most carried a single peptide derived from the class II-associa...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/s0092-8674(00)81029-6

    authors： Miyazaki T,Wolf P,Tourne S,Waltzinger C,Dierich A,Barois N,Ploegh H,Benoist C,Mathis D

    更新日期：1996-02-23 00:00:00

  • A unique pattern of integrated viral genes in hamster cells transformed by highly oncogenic human adenovirus 12.

    abstract：:We have analyzed the viral DNA sequences persisting in HE C19, a clonal line of hamster embryo cells transformed in vitro by human adenovirus 12 (Ad 12), a member of highly oncogenic group A. Saturation-hybridization of in vitro labeled Ad 12 DNA (2-4 x 10(8) cpm/mug) with HE C19 DNA showed that 93-100% of viral DNA s...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/0092-8674(76)90172-0

    authors： Green MR,Chinnadurai G,Mackey JK,Green M

    更新日期：1976-03-01 00:00:00

  • Crystal structure of the A domain from the alpha subunit of integrin CR3 (CD11b/CD18).

    abstract：:We have determined the high resolution crystal structure of the A domain from the alpha chain of integrin CR3. The domain adopts a classic alpha/beta "Rossmann" fold and contains an unusual Mg2+ coordination site at its surface. One of the coordinating ligands is the glutamate side chain from another A domain molecule...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/0092-8674(95)90517-0

    authors： Lee JO,Rieu P,Arnaout MA,Liddington R

    更新日期：1995-02-24 00:00:00

  • Transepithelial projections from basal cells are luminal sensors in pseudostratified epithelia.

    abstract：:Basal cells are by definition located on the basolateral side of several epithelia, and they have never been observed reaching the lumen. Using high-resolution 3D confocal imaging, we report that basal cells extend long and slender cytoplasmic projections that not only reach toward the lumen but can cross the tight ju...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/j.cell.2008.10.020

    authors： Shum WW,Da Silva N,McKee M,Smith PJ,Brown D,Breton S

    更新日期：2008-12-12 00:00:00

  • Apical localization of wingless transcripts is required for wingless signaling.

    abstract：:Many developing and adult tissues are comprised of polarized epithelia. Proteins that are asymmetrically distributed in these cells are thought to be localized by protein trafficking. Here we show that the distribution and function of the signaling protein Wingless is predetermined by the subcellular localization of i...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/s0092-8674(01)00311-7

    authors： Simmonds AJ,dosSantos G,Livne-Bar I,Krause HM

    更新日期：2001-04-20 00:00:00

  • Cellular Control of Viscosity Counters Changes in Temperature and Energy Availability.

    abstract：:Cellular functioning requires the orchestration of thousands of molecular interactions in time and space. Yet most molecules in a cell move by diffusion, which is sensitive to external factors like temperature. How cells sustain complex, diffusion-based systems across wide temperature ranges is unknown. Here, we uncov...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/j.cell.2020.10.017

    authors： Persson LB,Ambati VS,Brandman O

    更新日期：2020-12-10 00:00:00

  • Regulation of eukaryotic ribosomal RNA transcription by RNA polymerase modification.

    abstract：:Forms of RNA polymerase I prepared from growing or encysted Acanthamoeba are equal in the ability to transcribe poly(dl:dC). Polymerase from cysts, whose rRNA genes are transcriptionally inactive, is unable to utilize the rDNA promoter in vitro, whereas the transcription initiation factor from cysts is fully able to b...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/0092-8674(86)90601-x

    authors： Bateman E,Paule MR

    更新日期：1986-11-07 00:00:00

  • Specialized piRNA pathways act in germline and somatic tissues of the Drosophila ovary.

    abstract：:In Drosophila gonads, Piwi proteins and associated piRNAs collaborate with additional factors to form a small RNA-based immune system that silences mobile elements. Here, we analyzed nine Drosophila piRNA pathway mutants for their impacts on both small RNA populations and the subcellular localization patterns of Piwi ...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/j.cell.2009.03.040

    authors： Malone CD,Brennecke J,Dus M,Stark A,McCombie WR,Sachidanandam R,Hannon GJ

    更新日期：2009-05-01 00:00:00

  • The in vitro transcription of the 7SK RNA gene by RNA polymerase III is dependent only on the presence of an upstream promoter.

    abstract：:Deletion analysis was carried out on the human 7SK RNA gene to map regions essential for in vitro transcription by RNA polymerase III. The sequence promoting transcription is located between 37 and 3 bp upstream of the 7SK RNA coding region. RNA polymerase III transcription of adjacent plasmid sequences can be directe...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/0092-8674(87)90012-2

    authors： Murphy S,Di Liegro C,Melli M

    更新日期：1987-10-09 00:00:00

  • RNA polymerase III detects cytosolic DNA and induces type I interferons through the RIG-I pathway.

    abstract：:Type I interferons (IFNs) are important for antiviral and autoimmune responses. Retinoic acid-induced gene I (RIG-I) and mitochondrial antiviral signaling (MAVS) proteins mediate IFN production in response to cytosolic double-stranded RNA or single-stranded RNA containing 5'-triphosphate (5'-ppp). Cytosolic B form dou...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/j.cell.2009.06.015

    authors： Chiu YH,Macmillan JB,Chen ZJ

    更新日期：2009-08-07 00:00:00

  • AgRP Neurons Control Systemic Insulin Sensitivity via Myostatin Expression in Brown Adipose Tissue.

    abstract：:Activation of Agouti-related peptide (AgRP) neurons potently promotes feeding, and chronically altering their activity also affects peripheral glucose homeostasis. We demonstrate that acute activation of AgRP neurons causes insulin resistance through impairment of insulin-stimulated glucose uptake into brown adipose t...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/j.cell.2016.02.044

    authors： Steculorum SM,Ruud J,Karakasilioti I,Backes H,Engström Ruud L,Timper K,Hess ME,Tsaousidou E,Mauer J,Vogt MC,Paeger L,Bremser S,Klein AC,Morgan DA,Frommolt P,Brinkkötter PT,Hammerschmidt P,Benzing T,Rahmouni K,Wunder

    更新日期：2016-03-24 00:00:00

  • Heterogeneous mitochondrial DNA D-loop sequences in bovine tissue.

    abstract：:Mitochondrial DNA from bovine tissue contains heterogeneous sequences located within an evolutionary conserved cytosine homopolymer sequence near the 5' end of the D-loop region. This part of the mammalian mitochondrial genome is known to contain the origin of heavy strand DNA synthesis and the major transcriptional p...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/0092-8674(84)90434-3

    authors： Hauswirth WW,Van de Walle MJ,Laipis PJ,Olivo PD

    更新日期：1984-07-01 00:00:00

  • Targeting of aberrant mRNAs to cytoplasmic processing bodies.

    abstract：:In eukaryotes, a specialized pathway of mRNA degradation termed nonsense-mediated decay (NMD) functions in mRNA quality control by recognizing and degrading mRNAs with aberrant termination codons. We demonstrate that NMD in yeast targets premature termination codon (PTC)-containing mRNA to P-bodies. Upf1p is sufficien...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/j.cell.2006.04.037

    authors： Sheth U,Parker R

    更新日期：2006-06-16 00:00:00

  • Polypyrimidine segments in Drosophila melanogaster DNA: II. Chromosome location and nucleotide sequence.

    abstract：:Long pyrimidine tracts, purified from Drosophila melanogaster DNA after treatment with formic acid-diphenylamine, were used as template for E. coli RNA polymerase to produce a polynucleotide containing only purines. This polypurine RNA hybridized specifically to D. melanogaster DNA with high efficiency at low Cot valu...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/0092-8674(75)90026-4

    authors： Sederoff R,Lowenstein L

    更新日期：1975-06-01 00:00:00

  • Should you be tweeting?

    abstract：:Twitter needs no introduction. This "microblogging" service has gained tremendous popularity in the 2 years since its launch. Yet, most scientists are steering clear of it. Laura Bonetta speaks to some who have found value in tweeting. ...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/j.cell.2009.10.017

    authors： Bonetta L

    更新日期：2009-10-30 00:00:00

  • Rickettsia Sca4 Reduces Vinculin-Mediated Intercellular Tension to Promote Spread.

    abstract：:Spotted fever group (SFG) rickettsiae are human pathogens that infect cells in the vasculature. They disseminate through host tissues by a process of cell-to-cell spread that involves protrusion formation, engulfment, and vacuolar escape. Other bacterial pathogens rely on actin-based motility to provide a physical for...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/j.cell.2016.09.023

    authors： Lamason RL,Bastounis E,Kafai NM,Serrano R,Del Álamo JC,Theriot JA,Welch MD

    更新日期：2016-10-20 00:00:00

  • The Mitochondrial Unfolded Protein Response Is Mediated Cell-Non-autonomously by Retromer-Dependent Wnt Signaling.

    abstract：:The mitochondrial unfolded protein response (UPRmt) can be triggered in a cell-non-autonomous fashion across multiple tissues in response to mitochondrial dysfunction. The ability to communicate information about the presence of mitochondrial stress enables a global response that can ultimately better protect an organ...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/j.cell.2018.06.029

    authors： Zhang Q,Wu X,Chen P,Liu L,Xin N,Tian Y,Dillin A

    更新日期：2018-08-09 00:00:00

  • Viral RNAs: lessons from the enemy.

    abstract：:Viruses are adept at evolving or co-opting genomic elements that allow them to maximize their replication potential in the infected host. This evolutionary plasticity makes viruses an invaluable system to identify new mechanisms used not only by viruses but also by vertebrate cells to modulate gene expression. Here, I...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/j.cell.2009.01.048

    authors： Cullen BR

    更新日期：2009-02-20 00:00:00

  • OBF-1, a novel B cell-specific coactivator that stimulates immunoglobulin promoter activity through association with octamer-binding proteins.

    abstract：:Recent biochemical and genetic studies indicate that in addition to the octamer-binding proteins Oct-1 and Oct-2, other B cell components are required for lymphoid-restricted, octamer site-mediated immunoglobulin gene promoter activity. Using a genetic screen in yeast, we have isolated B cell-derived cDNAs encoding Oc...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/0092-8674(95)90500-6

    authors： Strubin M,Newell JW,Matthias P

    更新日期：1995-02-10 00:00:00

  • Café Scientifique--déjà vu.

    abstract：:Is the Café Scientifique a fashionable by-product of a comfortable age or an indicator of the changing relationship between science and society? ...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/j.cell.2006.07.006

    authors： Dallas D

    更新日期：2006-07-28 00:00:00

  • Cellular uptake of the tat protein from human immunodeficiency virus.

    abstract：:While developing an assay to measure the activity of the tat protein from human immunodeficiency virus 1 (HIV-1), we discovered that the purified protein could be taken up by cells growing in tissue culture and subsequently trans-activate the viral promoter. Trans-activation is dramatically increased by a variety of l...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/0092-8674(88)90263-2

    authors： Frankel AD,Pabo CO

    更新日期：1988-12-23 00:00:00

  • A Viral Immunoevasin Controls Innate Immunity by Targeting the Prototypical Natural Killer Cell Receptor Family.

    abstract：:Natural killer (NK) cells play a key role in innate immunity by detecting alterations in self and non-self ligands via paired NK cell receptors (NKRs). Despite identification of numerous NKR-ligand interactions, physiological ligands for the prototypical NK1.1 orphan receptor remain elusive. Here, we identify a viral ...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/j.cell.2017.03.002

    authors： Aguilar OA,Berry R,Rahim MMA,Reichel JJ,Popović B,Tanaka M,Fu Z,Balaji GR,Lau TNH,Tu MM,Kirkham CL,Mahmoud AB,Mesci A,Krmpotić A,Allan DSJ,Makrigiannis AP,Jonjić S,Rossjohn J,Carlyle JR

    更新日期：2017-03-23 00:00:00

  • Distinct Ventral Pallidal Neural Populations Mediate Separate Symptoms of Depression.

    abstract：:Major depressive disorder (MDD) patients display a common but often variable set of symptoms making successful, sustained treatment difficult to achieve. Separate depressive symptoms may be encoded by differential changes in distinct circuits in the brain, yet how discrete circuits underlie behavioral subsets of depre...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/j.cell.2017.06.015

    authors： Knowland D,Lilascharoen V,Pacia CP,Shin S,Wang EH,Lim BK

    更新日期：2017-07-13 00:00:00

  • TIGAR, a p53-inducible regulator of glycolysis and apoptosis.

    abstract：:The p53 tumor-suppressor protein prevents cancer development through various mechanisms, including the induction of cell-cycle arrest, apoptosis, and the maintenance of genome stability. We have identified a p53-inducible gene named TIGAR (TP53-induced glycolysis and apoptosis regulator). TIGAR expression lowered fruc...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/j.cell.2006.05.036

    authors： Bensaad K,Tsuruta A,Selak MA,Vidal MN,Nakano K,Bartrons R,Gottlieb E,Vousden KH

    更新日期：2006-07-14 00:00:00