Gene Expression Changes and Community Turnover Differentially Shape the Global Ocean Metatranscriptome.

Abstract:

:Ocean microbial communities strongly influence the biogeochemistry, food webs, and climate of our planet. Despite recent advances in understanding their taxonomic and genomic compositions, little is known about how their transcriptomes vary globally. Here, we present a dataset of 187 metatranscriptomes and 370 metagenomes from 126 globally distributed sampling stations and establish a resource of 47 million genes to study community-level transcriptomes across depth layers from pole-to-pole. We examine gene expression changes and community turnover as the underlying mechanisms shaping community transcriptomes along these axes of environmental variation and show how their individual contributions differ for multiple biogeochemically relevant processes. Furthermore, we find the relative contribution of gene expression changes to be significantly lower in polar than in non-polar waters and hypothesize that in polar regions, alterations in community activity in response to ocean warming will be driven more strongly by changes in organismal composition than by gene regulatory mechanisms. VIDEO ABSTRACT.

journal_name

Cell

journal_title

Cell

authors

Salazar G,Paoli L,Alberti A,Huerta-Cepas J,Ruscheweyh HJ,Cuenca M,Field CM,Coelho LP,Cruaud C,Engelen S,Gregory AC,Labadie K,Marec C,Pelletier E,Royo-Llonch M,Roux S,Sánchez P,Uehara H,Zayed AA,Zeller G,Carmichael

doi

10.1016/j.cell.2019.10.014

subject

Has Abstract

pub_date

2019-11-14 00:00:00

pages

1068-1083.e21

issue

5

eissn

0092-8674

issn

1097-4172

pii

S0092-8674(19)31164-X

journal_volume

179

pub_type

杂志文章

相关文献

CELL文献大全
  • Methylglyoxal comes of AGE.

    abstract::The posttranslational modification of proteins by methylglyoxal, a highly reactive compound derived from glycolysis, may contribute to aging, diabetes, and other disorders. In this issue of Cell, Brownlee and colleagues (Yao et al., 2006) demonstrate a specific mechanism by which methylglyoxal modifies a transcription...

    journal_title:Cell

    pub_type: 评论,杂志文章,评审

    doi:10.1016/j.cell.2006.01.002

    authors: Ramasamy R,Yan SF,Schmidt AM

    更新日期:2006-01-27 00:00:00

  • Disentangling Genetic and Environmental Effects on the Proteotypes of Individuals.

    abstract::Proteotypes, like genotypes, have been found to vary between individuals in several studies, but consistent molecular functional traits across studies remain to be quantified. In a meta-analysis of 11 proteomics datasets from humans and mice, we use co-variation of proteins in known functional modules across datasets ...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/j.cell.2019.03.015

    authors: Romanov N,Kuhn M,Aebersold R,Ori A,Beck M,Bork P

    更新日期:2019-05-16 00:00:00

  • Generation of unexpected editing patterns in Leishmania tarentolae mitochondrial mRNAs: misediting produced by misguiding.

    abstract::We have analyzed the generation of unexpected patterns of RNA editing, i.e., those not following a strict 3' to 5' progression, which occur in junction regions between fully edited and preedited sequences. Evidence is presented that these patterns are generated by misediting due to specific events of misguiding. Mised...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/0092-8674(92)90171-8

    authors: Sturm NR,Maslov DA,Blum B,Simpson L

    更新日期:1992-08-07 00:00:00

  • Direct visualization of protein transport and processing in the living cell by microinjection of specific antibodies.

    abstract::We have prepared polyclonal antibodies to the cytoplasmic portion of the envelope glycoprotein G of vesicular stomatitis virus (VSV) by using synthetic peptides corresponding to either the 22 or 11 ultimate carboxy-terminal residues of the G as immunogens. When antibodies to the 22 residue peptide are microinjected in...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/0092-8674(84)90195-8

    authors: Arnheiter H,Dubois-Dalcq M,Lazzarini RA

    更新日期:1984-11-01 00:00:00

  • A deubiquitinating enzyme interacts with SIR4 and regulates silencing in S. cerevisiae.

    abstract::The SIR2, SIR3, and SIR4 proteins are required for silencing of transcription at the silent mating type loci and at telomeres in yeast. Using protein affinity chromatography, we show that SIR2, SIR3, and two proteins of 69 and 110 kDa tightly associate with SIR4. Surprisingly, the 110 kDa SIR4-binding protein is ident...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/s0092-8674(00)80139-7

    authors: Moazed D,Johnson D

    更新日期:1996-08-23 00:00:00

  • Cell sorting during regenerative tissue formation.

    abstract::Regeneration of transected peripheral nerves is a complex process involving the coordinated action of neuronal axons, glial cells, and fibroblasts. Using rodent models of nerve repair, Parrinello et al. (2010) find that ephrin signaling between fibroblasts and Schwann cell progenitors, involving the stemness factor So...

    journal_title:Cell

    pub_type: 评论,杂志文章

    doi:10.1016/j.cell.2010.09.018

    authors: Klein R

    更新日期:2010-10-01 00:00:00

  • A B-lymphocyte-specific high-turnover protein: constitutive expression in resting B cells and induction of synthesis in proliferating cells.

    abstract::A basic B-cell-specific protein of 35,000 daltons (XM1) is expressed at a high rate--comparable to actin--in resting splenic B lymphocytes of various species. Splenic or thymic T cells or fibroblasts do not express this protein. Upon polyclonal stimulation of B lymphocytes or in proliferating B-lymphocyte-derived cell...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/0092-8674(82)90162-3

    authors: Rahmsdorf HJ,Mallick U,Ponta H,Herrlich P

    更新日期:1982-06-01 00:00:00

  • Flexible Ion Barrier.

    abstract::The central vasculature of plant roots is protected by a hydrophobic ring of endodermal cells that are enclosed by lamellae of suberin. Barberon et al. demonstrate that endodermal suberization plasticity facilitates ion homeostasis, with antithetical regulation of suberin deposition and degradation by the phytohormone...

    journal_title:Cell

    pub_type: 评论,杂志文章

    doi:10.1016/j.cell.2016.01.005

    authors: Pauluzzi G,Bailey-Serres J

    更新日期:2016-01-28 00:00:00

  • Sequence analysis and neuronal expression of fasciclin I in grasshopper and Drosophila.

    abstract::The fasciclin I, II, and III glycoproteins are expressed on different subsets of axon bundles (fascicles) in insect embryos and are thus candidates for surface recognition molecules involved in growth cone guidance. Here we present the sequence of grasshopper fasciclin I and the identification and sequence of the Dros...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/0092-8674(88)90574-0

    authors: Zinn K,McAllister L,Goodman CS

    更新日期:1988-05-20 00:00:00

  • Multilevel modulation of a sensory motor circuit during C. elegans sleep and arousal.

    abstract::Sleep is characterized by behavioral quiescence, homeostasis, increased arousal threshold, and rapid reversibility. Understanding how these properties are encoded by a neuronal circuit has been difficult, and no single molecular or neuronal pathway has been shown to be responsible for the regulation of sleep. Taking a...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/j.cell.2013.11.036

    authors: Cho JY,Sternberg PW

    更新日期:2014-01-16 00:00:00

  • Cell interactions coordinate the development of the C. elegans egg-laying system.

    abstract::Egg laying by the nematode Caenorhabditis elegans requires the functioning of the vulva, the gonad, the egg-laying muscles, and the two HSN neurons, which innervate these muscles. By analyzing a newly isolated mutant (dig-1) that displaces the gonad, we discovered that cell interactions coordinate the spatial relation...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/0092-8674(90)90382-o

    authors: Thomas JH,Stern MJ,Horvitz HR

    更新日期:1990-09-21 00:00:00

  • Dysregulated Microbial Fermentation of Soluble Fiber Induces Cholestatic Liver Cancer.

    abstract::Dietary soluble fibers are fermented by gut bacteria into short-chain fatty acids (SCFA), which are considered broadly health-promoting. Accordingly, consumption of such fibers ameliorates metabolic syndrome. However, incorporating soluble fiber inulin, but not insoluble fiber, into a compositionally defined diet, ind...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/j.cell.2018.09.004

    authors: Singh V,Yeoh BS,Chassaing B,Xiao X,Saha P,Aguilera Olvera R,Lapek JD Jr,Zhang L,Wang WB,Hao S,Flythe MD,Gonzalez DJ,Cani PD,Conejo-Garcia JR,Xiong N,Kennett MJ,Joe B,Patterson AD,Gewirtz AT,Vijay-Kumar M

    更新日期:2018-10-18 00:00:00

  • Raphe Circuits on the Menu.

    abstract::The dorsal raphe nucleus (DRN) is an important brain area for body-weight regulation. In this issue of Cell, Nectow et al. uncover cell-type-specific neural circuitry and pharmacology for appetite control within the DRN. ...

    journal_title:Cell

    pub_type: 评论,杂志文章

    doi:10.1016/j.cell.2017.07.017

    authors: Yang H,Sternson SM

    更新日期:2017-07-27 00:00:00

  • Ubiquitin is attached to membranes of baculovirus particles by a novel type of phospholipid anchor.

    abstract::Purified budded virions of Autographa californica nuclear polyhedrosis virus (AcNPV) contain abundant amounts of free ubiquitin, which has an altered electrophoretic mobility on SDS gels as compared with standard ubiquitin. Phase extraction of virion proteins with Triton X-114 indicated that the modified form of ubiqu...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/0092-8674(95)90413-1

    authors: Guarino LA,Smith G,Dong W

    更新日期:1995-01-27 00:00:00

  • SRV2, a gene required for RAS activation of adenylate cyclase in yeast.

    abstract::We have identified a gene, SRV2, mutations of which alleviate stress sensitivity in strains carrying an activated RAS gene. Epistasis analysis suggests that the gene affects accumulation of cAMP in the cell. Direct assays of cAMP accumulation indicate that mutations of the gene diminish the rate of in vivo production ...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/0092-8674(90)90813-t

    authors: Fedor-Chaiken M,Deschenes RJ,Broach JR

    更新日期:1990-04-20 00:00:00

  • Structural basis for autoinhibition of the Ephb2 receptor tyrosine kinase by the unphosphorylated juxtamembrane region.

    abstract::The Eph receptor tyrosine kinase family is regulated by autophosphorylation within the juxtamembrane region and the kinase activation segment. We have solved the X-ray crystal structure to 1.9 A resolution of an autoinhibited, unphosphorylated form of EphB2 comprised of the juxtamembrane region and the kinase domain. ...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/s0092-8674(01)00496-2

    authors: Wybenga-Groot LE,Baskin B,Ong SH,Tong J,Pawson T,Sicheri F

    更新日期:2001-09-21 00:00:00

  • DMC1: a meiosis-specific yeast homolog of E. coli recA required for recombination, synaptonemal complex formation, and cell cycle progression.

    abstract::DMC1 is a new meiosis-specific yeast gene. Dmc1 protein is structurally similar to bacterial RecA proteins. dmc1 mutants are defective in reciprocal recombination, accumulate double-strand break (DSB) recombination intermediates, fail to form normal synaptonemal complex (SC), and arrest late in meiotic prophase. dmc1 ...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/0092-8674(92)90446-j

    authors: Bishop DK,Park D,Xu L,Kleckner N

    更新日期:1992-05-01 00:00:00

  • Comparative analysis of the structural organization of two closely related vitellogenin genes in X. laevis.

    abstract::The structural organization of the two closely related vitellogenin genes A1 and A2 has been determined and compared by electron microscopy. In both genes the mRNA-coding sequence of 6 kb is interrupted 33 times, leading to a total gene length of 21 kb for gene A1 and 16 kb for gene A2. Thus both genes have a mean exo...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/0092-8674(80)90239-1

    authors: Wahli W,Dawid IB,Wyler T,Weber R,Ryffel GU

    更新日期:1980-05-01 00:00:00

  • Cln3 activates G1-specific transcription via phosphorylation of the SBF bound repressor Whi5.

    abstract::G1-specific transcriptional activation by Cln3/CDK initiates the budding yeast cell cycle. To identify targets of Cln3/CDK, we analyzed the SBF and MBF transcription factor complexes by multidimensional protein interaction technology (MudPIT). Whi5 was identified as a stably bound component of SBF but not MBF. Inactiv...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/j.cell.2004.05.025

    authors: de Bruin RA,McDonald WH,Kalashnikova TI,Yates J 3rd,Wittenberg C

    更新日期:2004-06-25 00:00:00

  • Integrated systems approach identifies genetic nodes and networks in late-onset Alzheimer's disease.

    abstract::The genetics of complex disease produce alterations in the molecular interactions of cellular pathways whose collective effect may become clear through the organized structure of molecular networks. To characterize molecular systems associated with late-onset Alzheimer's disease (LOAD), we constructed gene-regulatory ...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/j.cell.2013.03.030

    authors: Zhang B,Gaiteri C,Bodea LG,Wang Z,McElwee J,Podtelezhnikov AA,Zhang C,Xie T,Tran L,Dobrin R,Fluder E,Clurman B,Melquist S,Narayanan M,Suver C,Shah H,Mahajan M,Gillis T,Mysore J,MacDonald ME,Lamb JR,Bennett DA,

    更新日期:2013-04-25 00:00:00

  • The sequential action of miR156 and miR172 regulates developmental timing in Arabidopsis.

    abstract::The transition from the juvenile to the adult phase of shoot development in plants is accompanied by changes in vegetative morphology and an increase in reproductive potential. Here, we describe the regulatory mechanism of this transition. We show that miR156 is necessary and sufficient for the expression of the juven...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/j.cell.2009.06.031

    authors: Wu G,Park MY,Conway SR,Wang JW,Weigel D,Poethig RS

    更新日期:2009-08-21 00:00:00

  • The Cellular and Molecular Basis for Planarian Regeneration.

    abstract::Regeneration is one of the great mysteries of biology. Planarians are flatworms capable of dramatic feats of regeneration, which have been studied for over 2 centuries. Recent findings identify key cellular and molecular principles underlying these feats. A stem cell population (neoblasts) generates new cells and is c...

    journal_title:Cell

    pub_type: 杂志文章,评审

    doi:10.1016/j.cell.2018.09.021

    authors: Reddien PW

    更新日期:2018-10-04 00:00:00

  • GroEL/GroES-mediated folding of a protein too large to be encapsulated.

    abstract::The chaperonin GroEL binds nonnative proteins too large to fit inside the productive GroEL-GroES cis cavity, but whether and how it assists their folding has remained unanswered. We have examined yeast mitochondrial aconitase, an 82 kDa monomeric Fe(4)S(4) cluster-containing enzyme, observed to aggregate in chaperonin...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/s0092-8674(01)00523-2

    authors: Chaudhuri TK,Farr GW,Fenton WA,Rospert S,Horwich AL

    更新日期:2001-10-19 00:00:00

  • Methylation of deoxycytidine incorporated by excision-repair synthesis of DNA.

    abstract::Methylation of deoxycytidine incorporated by DNA excision-repair was studied in human diploid fibroblasts following damage with ultraviolet radiation, N-methyl-N-nitrosourea, or N-acetoxy-2-acetylaminofluorene. In confluent, nondividing cells, methylation in repair patches induced by all three agents is slow and incom...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/0092-8674(82)90248-3

    authors: Kastan MB,Gowans BJ,Lieberman MW

    更新日期:1982-09-01 00:00:00

  • Coordinate transcription of variant surface glycoprotein genes and an expression site associated gene family in Trypanosoma brucei.

    abstract::Trypanosoma brucei variant surface glycoprotein (VSG) genes are activated either by duplicative (DA) transposition of the gene to a pre-activated expression site or by nonduplicative (NDA) activation of a previously silent telomeric gene. We have obtained a recombinant clone spanning the 5' barren region of the expres...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/s0092-8674(85)80113-6

    authors: Cully DF,Ip HS,Cross GA

    更新日期:1985-08-01 00:00:00

  • The BELL1 gene encodes a homeodomain protein involved in pattern formation in the Arabidopsis ovule primordium.

    abstract::Ovule development in Arabidopsis involves the formation of three morphologically defined proximal-distal pattern elements. Integuments arise from the central pattern element. Analysis of Bell 1 (Bel 1) mutant ovules indicated that BEL1 was required for integument development. Cloning of the BEL1 locus reveals that it ...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/0092-8674(95)90186-8

    authors: Reiser L,Modrusan Z,Margossian L,Samach A,Ohad N,Haughn GW,Fischer RL

    更新日期:1995-12-01 00:00:00

  • DNA repair in an active gene: removal of pyrimidine dimers from the DHFR gene of CHO cells is much more efficient than in the genome overall.

    abstract::DNA repair was measured in the dihydrofolate reductase gene in Chinese hamster ovary cells, amplified for the gene, by quantitating pyrimidine dimers with a specific UV-endonuclease. More than two thirds of the dimers had been removed from a 14.1 kb restriction fragment of the gene by 26 hr after irradiation (20 J/m2)...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/0092-8674(85)90150-3

    authors: Bohr VA,Smith CA,Okumoto DS,Hanawalt PC

    更新日期:1985-02-01 00:00:00

  • Niche crosstalk: intercellular signals at the hair follicle.

    abstract::A recent series of papers, including Festa et al. (2011) in this issue, has revealed unexpected interdependent relationships among cell populations residing in and around the hair follicle. These interactions between different lineages of stem cells are crucial for hair follicle growth and cycling and point to a compl...

    journal_title:Cell

    pub_type: 评论,杂志文章

    doi:10.1016/j.cell.2011.08.020

    authors: Jahoda CA,Christiano AM

    更新日期:2011-09-02 00:00:00

  • Structural Basis for a Safety-Belt Mechanism That Anchors Condensin to Chromosomes.

    abstract::Condensin protein complexes coordinate the formation of mitotic chromosomes and thereby ensure the successful segregation of replicated genomes. Insights into how condensin complexes bind to chromosomes and alter their topology are essential for understanding the molecular principles behind the large-scale chromatin r...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/j.cell.2017.09.008

    authors: Kschonsak M,Merkel F,Bisht S,Metz J,Rybin V,Hassler M,Haering CH

    更新日期:2017-10-19 00:00:00

  • Suppressor of Hairless, the Drosophila homolog of the mouse recombination signal-binding protein gene, controls sensory organ cell fates.

    abstract::Suppressor of Hairless (Su(H)) is required at two stages of adult sensory organ development in Drosophila. Complete loss of Su(H) function results in a "neurogenic" phenotype in imaginal discs, in which too many cells adopt the sensory organ precursor cell fate. Su(H) is also involved in controlling the fates of sensi...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/0092-8674(92)90641-o

    authors: Schweisguth F,Posakony JW

    更新日期:1992-06-26 00:00:00