Abstract：
:How is the characteristic shape of an organelle generated? Recent work has provided insight into how the tubular network of the endoplasmic reticulum (ER) is formed. The tubules themselves are shaped by the reticulons and DP1/Yop1p, whereas their fusion into a network is brought about by membrane-bound GTPases that include the atlastins, Sey1p, and RHD3.
journal_name
Celljournal_title
Cellauthors
Hu J,Prinz WA,Rapoport TAdoi
10.1016/j.cell.2011.11.022subject
Has Abstractpub_date
2011-12-09 00:00:00pages
1226-31issue
6eissn
0092-8674issn
1097-4172pii
S0092-8674(11)01365-1journal_volume
147pub_type
杂志文章,评审相关文献
CELL文献大全abstract：:The MYC oncoproteins are thought to stimulate tumor cell growth and proliferation through amplification of gene transcription, a mechanism that has thwarted most efforts to inhibit MYC function as potential cancer therapy. Using a covalent inhibitor of cyclin-dependent kinase 7 (CDK7) to disrupt the transcription of a...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2014.10.024
更新日期：2014-11-20 00:00:00
abstract：:Regeneration of transected peripheral nerves is a complex process involving the coordinated action of neuronal axons, glial cells, and fibroblasts. Using rodent models of nerve repair, Parrinello et al. (2010) find that ephrin signaling between fibroblasts and Schwann cell progenitors, involving the stemness factor So...
journal_title：Cell
pub_type： 评论,杂志文章
doi：10.1016/j.cell.2010.09.018
更新日期：2010-10-01 00:00:00
abstract：:Use-dependent synapse remodeling is thought to provide a cellular mechanism for encoding durable memories, yet whether activity triggers an actual structural change has remained controversial. We use photoconductive stimulation to demonstrate activity-dependent morphological synaptic plasticity by video imaging of GFP...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/s0092-8674(01)00579-7
更新日期：2001-11-30 00:00:00
abstract：:The tumor suppressor p53 exerts antiproliferation effects through its ability to function as a sequence-specific DNA-binding transcription factor. Here, we demonstrate that p53 can be modified by acetylation both in vivo and in vitro. Remarkably, the site of p53 that is acetylated by its coactivator, p300, resides in ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/s0092-8674(00)80521-8
更新日期：1997-08-22 00:00:00
abstract：:RNA transcripts are subject to posttranscriptional gene regulation involving hundreds of RNA-binding proteins (RBPs) and microRNA-containing ribonucleoprotein complexes (miRNPs) expressed in a cell-type dependent fashion. We developed a cell-based crosslinking approach to determine at high resolution and transcriptome...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2010.03.009
更新日期：2010-04-02 00:00:00
abstract：:Yeast chromosomes terminate in tracts of simple repetitive DNA (poly[G1-3T]). Mutations in the gene TEL1 result in shortened telomeres. Sequence analysis of TEL1 indicates that it encodes a very large (322 kDa) protein with amino acid motifs found in phosphatidylinositol/protein kinases. The closest homolog to TEL1 is...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(95)90479-4
更新日期：1995-09-08 00:00:00
abstract：:Cells released from primary tumors seed metastases to specific organs by a nonrandom process, implying the involvement of biologically selective mechanisms. Based on clinical, functional, and molecular evidence, we show that the cytokine TGFbeta in the breast tumor microenvironment primes cancer cells for metastasis t...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2008.01.046
更新日期：2008-04-04 00:00:00
abstract：:In vitro enzymatic alteration of plasmid phenotype and in vitro construction of recombinant plasmids containing genetic information derived from the plasmid pSC101 have been used to investigate the mechanism of function of tetracycline resistance determined by the plasmid pSC101. The resistance has been shown to be in...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(78)90139-3
更新日期：1978-01-01 00:00:00
abstract：:Many organisms expand the information content of their genome through enzymatic methylation of cytosine residues. Here we report the 2.8 A crystal structure of a bacterial DNA (cytosine-5)-methyltransferase (DCMtase), M. HaeIII, bound covalently to DNA. In this complex, the substrate cytosine is extruded from the DNA ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(95)90060-8
更新日期：1995-07-14 00:00:00
abstract：:As the second dimension to the genome, the epigenome contains key information specific to every type of cells. Thousands of human epigenome maps have been produced in recent years thanks to rapid development of high throughput epigenome mapping technologies. In this review, we discuss the current epigenome mapping too...
journal_title：Cell
pub_type： 杂志文章,评审
doi：10.1016/j.cell.2013.09.011
更新日期：2013-09-26 00:00:00
abstract：:The redox-regulated chaperone Hsp33 protects organisms against oxidative stress that leads to protein unfolding. Activation of Hsp33 is triggered by the oxidative unfolding of its own redox-sensor domain, making Hsp33 a member of a recently discovered class of chaperones that require partial unfolding for full chapero...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2012.01.045
更新日期：2012-03-02 00:00:00
abstract：:G1-specific transcriptional activation by Cln3/CDK initiates the budding yeast cell cycle. To identify targets of Cln3/CDK, we analyzed the SBF and MBF transcription factor complexes by multidimensional protein interaction technology (MudPIT). Whi5 was identified as a stably bound component of SBF but not MBF. Inactiv...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2004.05.025
更新日期：2004-06-25 00:00:00
abstract：:The association of histone modification changes with autism spectrum disorder (ASD) has not been systematically examined. We conducted a histone acetylome-wide association study (HAWAS) by performing H3K27ac chromatin immunoprecipitation sequencing (ChIP-seq) on 257 postmortem samples from ASD and matched control brai...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2016.10.031
更新日期：2016-11-17 00:00:00
abstract：:Wnt signaling plays a critical role in embryonic development, and genetic aberrations in this network have been broadly implicated in colorectal cancer. We find that the Wnt receptor Frizzled2 (Fzd2) and its ligands Wnt5a/b are elevated in metastatic liver, lung, colon, and breast cancer cell lines and in high-grade t...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2014.10.032
更新日期：2014-11-06 00:00:00
abstract：:The minimal DNA sequence required for the formation of a stable complex with Drosophila heat shock factor (HSF) in vitro is an inverted repeat of a 5 bp recognition unit, -GAA-. Surprisingly, both permutations of this 5 bp unit, head-to-head and tail-to-tail, bind to HSF with similar affinity and with striking 2-fold ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(89)90603-x
更新日期：1989-12-01 00:00:00
abstract：:Protein-tyrosine phosphatases (PTPs), along with protein-tyrosine kinases, play key roles in cellular signaling. All Class I PTPs contain an essential active site cysteinyl residue, which executes a nucleophilic attack on substrate phosphotyrosyl residues. The high reactivity of the catalytic cysteine also predisposes...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2011.07.020
更新日期：2011-09-02 00:00:00
abstract：:The HIV-1 matrix (MA) protein contains two subcellular localization signals with opposing effects. A myristoylated N-terminus governs particle assembly at the plasma membrane, and a nucleophilic motif facilitates import of the viral preintegration complex into the nucleus of nondividing cells. Here, we show that myris...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(95)90488-3
更新日期：1995-02-10 00:00:00
abstract：:Monkey cell lines that constitutively synthesize 38.6 kd lac repressor protein and bear stably integrated chloramphenicol acetyl transferase (CAT) genes linked to a lac operator-containing SV40 early promoter-enhancer were generated. When grown in medium containing isopropyl beta-D-thiogalactoside (IPTG), these cells ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(88)90409-6
更新日期：1988-03-11 00:00:00
abstract：:Lower urinary tract infections are among the most common human bacterial infections, but extension to the kidneys is rare. This has been attributed to mechanical forces, such as urine flow, that prevent the ascent of bladder microbes. Here, we show that the regional hypersalinity, required for the kidney's urine-conce...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2017.07.022
更新日期：2017-08-24 00:00:00
abstract：:Purified reovirus synthesizes in vitro a mixture of mRNA molecules that contain 5' terminal structures of the type ppG..., GpppG..., and m7GpppGm, the relative amount of each depending upon the presence of S-adenosylmethionine (SAM) or S-adenosylhomocysteine (SAH) in the transcription incubation mixture. Reovirus mRNA...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(75)90009-4
更新日期：1975-10-01 00:00:00
abstract：:Release of CHO-K1 cells from plateau or stationary phase and reentry into the cell cycle is specifically and reversibly blocked at two distinct sites by the anticalmodulin drug W13. The first block occurs early during release while the cells are still at G0/G1, whereas the second occurs later in reentry during early S...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(84)90075-8
更新日期：1984-01-01 00:00:00
abstract：:The therapeutic value of DNA-damaging antineoplastic agents is dependent upon their ability to induce tumor cell apoptosis while sparing most normal tissues. Here, we show that a component of the apoptotic response to these agents in several different types of tumor cells is the deamidation of two asparagines in the u...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/s0092-8674(02)00972-8
更新日期：2002-10-04 00:00:00
abstract：:Pancreatic beta cell-surface expression of glucose transporter 2 (Glut-2) is essential for glucose-stimulated insulin secretion, thereby controlling blood glucose homeostasis in response to dietary intake. We show that the murine GlcNAcT-IVa glycosyltransferase is required for Glut-2 residency on the beta cell surface...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2005.09.041
更新日期：2005-12-29 00:00:00
abstract：:The frequencies of transformations of primary human and Chinese hamster fibroblasts have been compared with the spontaneous and induced frequencies of mutation for resistance to thioguanine and ouabain, and for ability to use fructose, using the carcinogens benzo (alpha) pyrene and urethane. Whereas the rates and freq...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(78)90215-5
更新日期：1978-04-01 00:00:00
abstract：:The pathway of RNA polymerase entry at the lac promoter was studied by investigating the relationship between the promoter and a weak, overlapping polymerase interaction site (P2). If polymerase is made to enter the DNA by binding in vitro at this P2 site, cyclic AMP receptor protein (CRP) actively removes polymerase ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(85)90250-8
更新日期：1985-12-01 00:00:00
abstract：:Cytotoxic brain edema triggered by neuronal swelling is the chief cause of mortality following brain trauma and cerebral infarct. Using fluorescence lifetime imaging to analyze contributions of intracellular ionic changes in brain slices, we find that intense Na(+) entry triggers a secondary increase in intracellular ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2015.03.029
更新日期：2015-04-23 00:00:00
abstract：:Coliphage N4 virion-encapsidated, DNA-dependent RNA polymerase (vRNAP) is inactive on double-stranded N4 DNA; however, denatured promoter-containing templates are accurately transcribed. We report that all determinants of vRNAP promoter recognition exist in the template strand, indicating that this enzyme is a site-sp...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(92)90173-a
更新日期：1992-08-07 00:00:00
abstract：:Plasmids expressing partial-length sense or antisense protein 4.1 RNA were microinjected into fertilized Xenopus eggs. Nuclease protection assays reveal that antisense protein 4.1 RNA lead to the specific loss of endogenous protein 4.1 transcripts after midblastula transition, with no effect on the levels of three unr...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(88)90576-4
更新日期：1988-05-20 00:00:00
abstract：:Telomeres of Oxytricha nova macronuclear chromosomes consist of a repeated T4G4 sequence, single-stranded at the 3' terminus, bound by a heterodimeric protein. The cloning of genes for the two polypeptides and their separate expression in E. coli have enabled evaluation of their individual contributions to DNA binding...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(91)90075-a
更新日期：1991-11-15 00:00:00
abstract：:Mice homozygous for a targeted mutation of the Hoxa-2 (Hox 1.11) gene are born with cleft palates and die within 24 hr of birth. Analysis of stained skeletons revealed that homozygous mutant animals contained multiple cranial skeletal defects, including a duplication of the ossification centers of the bones of the mid...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(93)90619-2
更新日期：1993-12-31 00:00:00
