Abstract:
:The synthesis and secretion of plasminogen activator by cultured macrophages can be induced and stimulated by concanavalin A and by phorbol myristate acetate, and inhibited by such agents as glucocorticoids, mitotic inhibitors and compounds affecting cAMP metabolism. By the manipulation of stimulatory and inhibitory influences, enzyme production can be modulated continuously over a 200 fold range. In the same way, the proportion of cells that secrete detectable levels of enzyme can be varied from 1-90%. No comparable modulation of lysozyme or acid hydrolase production is observed under the same conditions. These results suggest that the physiological control of macrophage plasminogen activator production is achieved by the interacting effects of mutually antagonistic stimuli; this emphasizes the utility of this enzyme for the study of regulatory phenomena, including those relating to inflammation.
journal_name
Celljournal_title
Cellauthors
Vassalli JD,Hamilton J,Reich Edoi
10.1016/0092-8674(77)90086-1subject
Has Abstractpub_date
1977-07-01 00:00:00pages
695-705issue
3eissn
0092-8674issn
1097-4172pii
0092-8674(77)90086-1journal_volume
11pub_type
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