Abstract:
:V(D)J recombination of antigen receptor gene segments in B and T cells is mediated by the lymphoid-specific proteins RAG1 and RAG2. Now, Ji et al. (2010) demonstrate how RAG1 and RAG2 use DNA sequence specificity and modified histones within chromatin to target specific loci for V(D)J recombination at different stages of lymphoid development.
journal_name
Celljournal_title
Cellauthors
Schlissel MSdoi
10.1016/j.cell.2010.04.014subject
Has Abstractpub_date
2010-04-30 00:00:00pages
400-2issue
3eissn
0092-8674issn
1097-4172pii
S0092-8674(10)00431-9journal_volume
141pub_type
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