Abstract:
:Two cDNAs were isolated whose dimerized products bind specifically to a DNA sequence, kappa E2, located in the immunoglobulin kappa chain enhancer. Both cDNAs share a region of extensive identity to the Drosophila daughterless gene and obvious similarity to a segment in three myc proteins, MyoD, and members of the Drosophila achaete-scute and twist gene family. The homologous regions have the potential to form two amphipathic helices separated by an intervening loop. Remarkable is the stringent conservation of hydrophobic residues present in both helices. We demonstrate that this new motif plays a crucial role in both dimerization and DNA binding.
journal_name
Celljournal_title
Cellauthors
Murre C,McCaw PS,Baltimore Ddoi
10.1016/0092-8674(89)90682-xsubject
Has Abstractpub_date
1989-03-10 00:00:00pages
777-83issue
5eissn
0092-8674issn
1097-4172pii
0092-8674(89)90682-Xjournal_volume
56pub_type
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