Abstract：
:IFN-γ-activated macrophages attempt to limit pathogen growth through tryptophan starvation. Zhang et al. demonstrate that Mycobacterium tuberculosis responds to this threat by synthesizing its own tryptophan. Genetic and chemical inhibition of this pathway reduces mycobacterial survival, revealing a new immune-dependent drug target for tuberculosis.
journal_name
Celljournal_title
Cellauthors
Russell DGdoi
10.1016/j.cell.2013.11.015subject
Has Abstractpub_date
2013-12-05 00:00:00pages
1209-10issue
6eissn
0092-8674issn
1097-4172pii
S0092-8674(13)01428-1journal_volume
155pub_type
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