Abstract：
:There are still no effective treatments to prevent, halt, or reverse Alzheimer's disease, but research advances over the past three decades could change this gloomy picture. Genetic studies demonstrate that the disease has multiple causes. Interdisciplinary approaches combining biochemistry, molecular and cell biology, and transgenic modeling have revealed some of its molecular mechanisms. Progress in chemistry, radiology, and systems biology is beginning to provide useful biomarkers, and the emergence of personalized medicine is poised to transform pharmaceutical development and clinical trials. However, investigative and drug development efforts should be diversified to fully address the multifactoriality of the disease.
journal_name
Celljournal_title
Cellauthors
Huang Y,Mucke Ldoi
10.1016/j.cell.2012.02.040subject
Has Abstractpub_date
2012-03-16 00:00:00pages
1204-22issue
6eissn
0092-8674issn
1097-4172pii
S0092-8674(12)00278-4journal_volume
148pub_type
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