Procollagen and collagen produced by a teratocarcinoma-derived cell line, TSD4: evidence for a new molecular form of collagen.

abstract：:An adaptive variant of the human Ectodysplasin receptor, EDARV370A, is one of the strongest candidates of recent positive selection from genome-wide scans. We have modeled EDAR370A in mice and characterized its phenotype and evolutionary origins in humans. Our computational analysis suggests the allele arose in centra...

journal_title：Cell

authors： Kamberov YG,Wang S,Tan J,Gerbault P,Wark A,Tan L,Yang Y,Li S,Tang K,Chen H,Powell A,Itan Y,Fuller D,Lohmueller J,Mao J,Schachar A,Paymer M,Hostetter E,Byrne E,Burnett M,McMahon AP,Thomas MG,Lieberman DE,Jin

更新日期：2013-02-14 00:00:00

abstract：:A diverse range of ultimate chemical carcinogens inhibited the transfer of methyl groups from S-adenosylmethionine to hemimethylated DNA in a reaction catalyzed by mouse spleen methyltransferase. The formation of alkali-labile sites in DNA lessened its ability to accept methyl groups in vitro, but the methylation reac...

journal_title：Cell

authors： Wilson VL,Jones PA

更新日期：1983-01-01 00:00:00

abstract：:Rubisco, the key enzyme of CO2 fixation in photosynthesis, is prone to inactivation by inhibitory sugar phosphates. Inhibited Rubisco undergoes conformational repair by the hexameric AAA+ chaperone Rubisco activase (Rca) in a process that is not well understood. Here, we performed a structural and mechanistic analysis...

journal_title：Cell

authors： Flecken M,Wang H,Popilka L,Hartl FU,Bracher A,Hayer-Hartl M

更新日期：2020-10-15 00:00:00

abstract：:The presentation of peptides to T cells by MHC class II molecules is of critical importance in specific recognition by the immune system. Expression of class II molecules is exquisitely controlled at the transcriptional level. A large set of proteins interact with the promoters of class II genes. The most important of...

journal_title：Cell

authors： Ting JP,Trowsdale J

更新日期：2002-04-01 00:00:00

abstract：:In this issue of Cell, Noma et al. (2006) show that B-boxes and TFIIIC limit the spread of heterochromatin at the silent mat region in the fission yeast genome. Global analysis of TFIIIC distribution revealed dispersed sites of association that coalesce at the nuclear periphery, suggesting that TFIIIC may act as a bar...

journal_title：Cell

authors： Wallrath LL,Geyer PK

更新日期：2006-06-02 00:00:00

abstract：:An examination of Abelson murine leukemia virus (A-MuL V)-hematopoietic cell interaction in cultures of fetal tissues reveals that A-MuLV can stimulate the formation of two different types of colonies. One type of colony is white and composed of A-MuLV-transformed lymphoid cells that can develop into established cell ...

journal_title：Cell

authors： Waneck GL,Rosenberg N

更新日期：1981-10-01 00:00:00

abstract：:Twitter needs no introduction. This "microblogging" service has gained tremendous popularity in the 2 years since its launch. Yet, most scientists are steering clear of it. Laura Bonetta speaks to some who have found value in tweeting. ...

journal_title：Cell

authors： Bonetta L

更新日期：2009-10-30 00:00:00

abstract：:Synapse formation requires changes in cell morphology and the upregulation and localization of synaptic proteins. In the cerebellum, mossy fibers undergo extensive remodeling as they contact several granule cells and form complex, multisynaptic glomerular rosettes. Here we show that granule cells secrete factors that ...

journal_title：Cell

authors： Hall AC,Lucas FR,Salinas PC

更新日期：2000-03-03 00:00:00

abstract：:We have tested a model for global ribosome biosynthesis by examining the effects of increased gene dosage on the synthesis of rRNA. Increasing gene dosage does not lead to a significant increase in total rRNA transcription; i.e., rRNA synthesis from individual rRNA operons is reduced to keep total rRNA production unch...

journal_title：Cell

authors： Jinks-Robertson S,Gourse RL,Nomura M

更新日期：1983-07-01 00:00:00

abstract：:The X-linked Foxp3 is a member of the forkhead/winged helix transcription factor family. Germline mutations cause lethal autoimmune diseases in males. Serendipitously, we observed that female mice heterozygous for the "scurfin" mutation of the Foxp3 gene (Foxp3(sf/+)) developed cancer at a high rate. The majority of t...

journal_title：Cell

authors： Zuo T,Wang L,Morrison C,Chang X,Zhang H,Li W,Liu Y,Wang Y,Liu X,Chan MW,Liu JQ,Love R,Liu CG,Godfrey V,Shen R,Huang TH,Yang T,Park BK,Wang CY,Zheng P,Liu Y

更新日期：2007-06-29 00:00:00

abstract：:The intermediate filament proteins, desmin and vimentin, are phosphorylated in skeletal muscle cells in vivo. Desmin kinase activities have been purified from mature chicken skeletal muscle and identified as the cAMP-dependent kinases. Chicken skeletal muscle contains two cAMP-dependent protein kinases which are simil...

journal_title：Cell

authors： O'Connor CM,Gard DL,Lazarides E

更新日期：1981-01-01 00:00:00

abstract：:The switch from short-term to long-term facilitation of the synapses between sensory and motor neurons mediating gill and tail withdrawal reflexes in Aplysia requires CREB-mediated transcription and new protein synthesis. We isolated several downstream genes, one of which encodes a neuron-specific ubiquitin C-terminal...

journal_title：Cell

authors： Hegde AN,Inokuchi K,Pei W,Casadio A,Ghirardi M,Chain DG,Martin KC,Kandel ER,Schwartz JH

更新日期：1997-04-04 00:00:00

abstract：:Homology is an important feature of recombination. We have used the rll cistrons of bacteriophage T4 to determine the extent of homology required for recombination. We varied the amount of homologous DNA available for recombination in both marker rescue experiments and deletion-by-deletion crosses. Our results suggest...

journal_title：Cell

authors： Singer BS,Gold L,Gauss P,Doherty DH

更新日期：1982-11-01 00:00:00

abstract：:Using cryo-electron microscopy, we have solved the structure of an icosidodecahedral COPII coat involved in cargo export from the endoplasmic reticulum (ER) coassembled from purified cargo adaptor Sec23-24 and Sec13-31 lattice-forming complexes. The coat structure shows a tetrameric assembly of the Sec23-24 adaptor la...

journal_title：Cell

authors： Stagg SM,LaPointe P,Razvi A,Gürkan C,Potter CS,Carragher B,Balch WE

更新日期：2008-08-08 00:00:00

abstract：:Exit from mitosis must not occur prior to partitioning of chromosomes between daughter cells. We find that the GTP binding protein Tem1, a regulator of mitotic exit, is present on the spindle pole body that migrates into the bud during S phase and mitosis. Tem1's exchange factor, Lte1, localizes to the bud. Thus, Tem1...

journal_title：Cell

authors： Bardin AJ,Visintin R,Amon A

更新日期：2000-07-07 00:00:00

abstract：:Protease-activated receptors (PARs) are a unique class of G protein-coupled receptors that play critical roles in thrombosis, inflammation, and vascular biology. PAR1 is proposed to be involved in the invasive and metastatic processes of various cancers. However, the protease responsible for activating the proinvasive...

journal_title：Cell

authors： Boire A,Covic L,Agarwal A,Jacques S,Sherifi S,Kuliopulos A

更新日期：2005-02-11 00:00:00

abstract：:Here, we show that the beta-chemokine receptor CKR-5 serves as a cofactor for M-tropic HIV viruses. Expression of CKR-5 with CD4 enables nonpermissive cells to form syncytia with cells expressing M-tropic, but not T-tropic, HIV-1 env proteins. Expression of CKR-5 and CD4 enables entry of a M-tropic, but not a T-tropic...

journal_title：Cell

authors： Doranz BJ,Rucker J,Yi Y,Smyth RJ,Samson M,Peiper SC,Parmentier M,Collman RG,Doms RW

更新日期：1996-06-28 00:00:00

abstract：:A clonally diverse anticipatory repertoire in which each lymphocyte bears a unique antigen receptor is the central feature of the adaptive immune system that evolved in our vertebrate ancestors. The survival advantage gained through adding this type of adaptive immune system to a pre-existing innate immune system led ...

journal_title：Cell

authors： Cooper MD,Alder MN

更新日期：2006-02-24 00:00:00

abstract：:The 2.2 kb mRNA of the Dictyostelium discoideum prespore gene EB4-PSV is constitutively transcribed during growth and development, but the message is only accumulated when cells form aggregates and establish the prespore-prestalk pattern. Disruption of the pattern by mechanical disaggregation results in a rapid loss o...

journal_title：Cell

authors： Hildebrandt M,Nellen W

更新日期：1992-04-03 00:00:00

abstract：:During the SOS response, LexA repressor is inactivated by specific cleavage. Although cleavage requires RecA protein in vivo, RecA acts indirectly as a coprotease by stimulating an inherent self-cleavage activity of LexA. In lambda lysogens, cleavage of lambda Cl repressor in a similar but far slower reaction results ...

journal_title：Cell

authors： Kim B,Little JW

更新日期：1993-06-18 00:00:00

abstract：:Synaptic plasticity in response to changes in physiologic state is coordinated by hormonal signals across multiple neuronal cell types. Here, we combine cell-type-specific electrophysiological, pharmacological, and optogenetic techniques to dissect neural circuits and molecular pathways controlling synaptic plasticity...

journal_title：Cell

authors： Yang Y,Atasoy D,Su HH,Sternson SM

更新日期：2011-09-16 00:00:00

abstract：:The location of cis-acting regulatory sequences within the long terminal repeat (LTR) of the human T cell lymphotropic virus type III (HTLV-III/LAV) was determined. An enhancer element capable of increasing the rate of transcription from a heterologous promoter, irrespective of distance and orientation, is located bet...

journal_title：Cell

authors： Rosen CA,Sodroski JG,Haseltine WA

更新日期：1985-07-01 00:00:00

abstract：:Noncoding RNAs (ncRNA) participate in epigenetic regulation but are poorly understood. Here we characterize the transcriptional landscape of the four human HOX loci at five base pair resolution in 11 anatomic sites and identify 231 HOX ncRNAs that extend known transcribed regions by more than 30 kilobases. HOX ncRNAs ...

journal_title：Cell

authors： Rinn JL,Kertesz M,Wang JK,Squazzo SL,Xu X,Brugmann SA,Goodnough LH,Helms JA,Farnham PJ,Segal E,Chang HY

更新日期：2007-06-29 00:00:00

abstract：:Multiple proteins act co-operatively in mammalian clathrin-mediated endocytosis (CME) to generate endocytic vesicles from the plasma membrane. The principles controlling the activation and organization of the actin cytoskeleton during mammalian CME are, however, not fully understood. Here, we show that the protein FCH...

journal_title：Cell

authors： Almeida-Souza L,Frank RAW,García-Nafría J,Colussi A,Gunawardana N,Johnson CM,Yu M,Howard G,Andrews B,Vallis Y,McMahon HT

更新日期：2018-07-12 00:00:00

abstract：:The assembly of COPI into a cage-like lattice sculpts membrane vesicles that transport cargo from the Golgi apparatus. Now, Lee and Goldberg (2010) present X-ray crystal structures of COPI suggesting that these coats combine selected features of two other archetypal coats, clathrin and COPII. ...

journal_title：Cell

authors： Hughson FM

更新日期：2010-07-09 00:00:00

abstract：:Ventral midline cells at different rostrocaudal levels of the central nervous system exhibit distinct properties but share the ability to pattern the dorsoventral axis of the neural tube. We show here that ventral midline cells acquire distinct identities in response to the different signaling activities of underlying...

journal_title：Cell

authors： Dale JK,Vesque C,Lints TJ,Sampath TK,Furley A,Dodd J,Placzek M

更新日期：1997-07-25 00:00:00

abstract：:mRNA made in eukaryotic cells typically has a 3' poly(A) tail that is added posttranscriptionally. To investigate mechanisms by which 3' poly(A) is formed, we identified the genes for the two vaccina virus-encoded polypeptides, VP55 and VP39. Primer-dependent polyadenylation activity was associated exclusively with pu...

journal_title：Cell

authors： Gershon PD,Ahn BY,Garfield M,Moss B

更新日期：1991-09-20 00:00:00

abstract：:Receptor-interacting protein kinase (RIPK)-1 is involved in RIPK3-dependent and -independent signaling pathways leading to cell death and/or inflammation. Genetic ablation of ripk1 causes postnatal lethality, which was not prevented by deletion of ripk3, caspase-8, or fadd. However, animals that lack RIPK1, RIPK3, and...

journal_title：Cell

authors： Dillon CP,Weinlich R,Rodriguez DA,Cripps JG,Quarato G,Gurung P,Verbist KC,Brewer TL,Llambi F,Gong YN,Janke LJ,Kelliher MA,Kanneganti TD,Green DR

更新日期：2014-05-22 00:00:00

abstract：:Embryonal carcinoma cell lines present strong developmental analogies with early embryonic cells. Previous studies have shown that treatment of F9 teratocarcinoma cells with retinoic acid induces the expression of the classical transplantation antigens which are indispensable for effective interactions between cells. ...

journal_title：Cell

authors： Tanaka K,Appella E,Jay G

更新日期：1983-12-01 00:00:00

abstract：:Phage G1 gp67 is a 23 kDa protein that binds to the Staphylococcus aureus (Sau) RNA polymerase (RNAP) σ(A) subunit and blocks cell growth by inhibiting transcription. We show that gp67 has little to no effect on transcription from most promoters but is a potent inhibitor of ribosomal RNA transcription. A 2.0-Å-resolut...

journal_title：Cell

authors： Osmundson J,Montero-Diez C,Westblade LF,Hochschild A,Darst SA

更新日期：2012-11-21 00:00:00