Abstract：
:Characteristic of chronic myelogenous leukemia (CML) is the presence of the chimeric p210(bcr-abl) protein possessing elevated protein tyrosine kinase activity relative to normal c-abl tyrosine kinase. Hematopoietic progenitors isolated from CML patients in the chronic phase contain a constitutively tyrosine-phosphorylated protein that migrates at 62 kDa by SDS-PAGE and associates with the p120 ras GTPase-activating protein (GAP). We have purified p62(dok) from a hematopoietic cell line expressing p210(bcr-abl). p62(dok) is a novel protein with features of a signaling molecule. Association of p62(dok) with GAP correlates with its tyrosine phosphorylation. p62(dok) is rapidly tyrosine-phosphorylated upon activation of the c-Kit receptor, implicating it as a component of a signal transduction pathway downstream of receptor tyrosine kinases.
journal_name
Celljournal_title
Cellauthors
Carpino N,Wisniewski D,Strife A,Marshak D,Kobayashi R,Stillman B,Clarkson Bdoi
10.1016/s0092-8674(00)81840-1subject
Has Abstractpub_date
1997-01-24 00:00:00pages
197-204issue
2eissn
0092-8674issn
1097-4172pii
S0092-8674(00)81840-1journal_volume
88pub_type
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