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Metastatic potential: generic predisposition of the primary tumor or rare, metastatic variants-or both?

Abstract：

:Metastasis is a rare event. Does it arise from rare, variant, highly metastatic cells or does a primary tumor progress to a premalignant state from which metastases arise stochastically without further changes in gene expression? Arguments and evidence have been adduced to support either position. A paper in this month's Cancer Cell and other arguments instead suggest models combining features of both.

journal_name

Cell

journal_title

Cell

authors

Hynes RO

doi

10.1016/s0092-8674(03)00468-9

subject

Has Abstract

pub_date

2003-06-27 00:00:00

pages

821-3

issue

7

eissn

0092-8674

issn

1097-4172

pii

S0092867403004689

journal_volume

113

pub_type

杂志文章,评审

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