Abstract：
:The science advisor to the US president has the opportunity to influence how scientific research is supported by the federal government, as well as the ways in which science and technology can be applied to meet the needs of society.
journal_name
Celljournal_title
Cellauthors
Lane NF,Matthews KRdoi
10.1016/j.cell.2009.11.024subject
Has Abstractpub_date
2009-11-25 00:00:00pages
847-50issue
5eissn
0092-8674issn
1097-4172pii
S0092-8674(09)01436-6journal_volume
139pub_type
杂志文章相关文献
CELL文献大全abstract：:Polycomb group proteins control a hierarchy of gene expression during the differentiation of stem cells. In this issue, Ezhkova et al. (2009) show that repression mediated by Polycomb proteins controls the timing of differentiation of precursor cells of the epidermal lineage. ...
journal_title：Cell
pub_type： 评论,杂志文章
doi：10.1016/j.cell.2009.03.004
更新日期：2009-03-20 00:00:00
abstract：:In prokaryotes, DNA can be segregated by three different types of cytoskeletal filaments. The best-understood type of partitioning (par) locus encodes an actin homolog called ParM, which forms dynamically unstable filaments that push plasmids apart in a process reminiscent of mitosis. However, the most common type of ...
journal_title：Cell
pub_type： 杂志文章,评审
doi：10.1016/j.cell.2010.05.033
更新日期：2010-06-11 00:00:00
abstract：:A recent series of papers, including Festa et al. (2011) in this issue, has revealed unexpected interdependent relationships among cell populations residing in and around the hair follicle. These interactions between different lineages of stem cells are crucial for hair follicle growth and cycling and point to a compl...
journal_title：Cell
pub_type： 评论,杂志文章
doi：10.1016/j.cell.2011.08.020
更新日期：2011-09-02 00:00:00
abstract：:The human multidrug resistance P-glycoprotein is an active transporter that pumps cytotoxic drugs out of cells. Expression of P-glycoprotein is also associated with a volume-activated chloride channel. Here we address the relationship between these two functions. Drug transport requires ATP hydrolysis while, in contra...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(92)90263-c
更新日期：1992-10-02 00:00:00
abstract：:We have adopted Drosophila tissue culture cells as a host system for studying the structure and function of mammalian transcription factors. These cells provide an Sp1-deficient background and have been used in a complementation assay to identify functional domains of human transcription factor Sp1. The SV40 early pro...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(88)90144-4
更新日期：1988-12-02 00:00:00
abstract：:Neurons typically settle at positions that match the location of their synaptic targets, creating topographic maps. In the spinal cord, the organization of motor neurons into discrete clusters is linked to the location of their muscle targets, establishing a topographic map of punctate design. To define the significan...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2011.09.037
更新日期：2011-10-28 00:00:00
abstract：:We predict regulatory targets for 14 Arabidopsis microRNAs (miRNAs) by identifying mRNAs with near complementarity. Complementary sites within predicted targets are conserved in rice. Of the 49 predicted targets, 34 are members of transcription factor gene families involved in developmental patterning or cell differen...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/s0092-8674(02)00863-2
更新日期：2002-08-23 00:00:00
abstract：:DNA double-strand breaks (DSBs) in B lymphocytes arise stochastically during replication or as a result of targeted DNA damage by activation-induced cytidine deaminase (AID). Here we identify recurrent, early replicating, and AID-independent DNA lesions, termed early replication fragile sites (ERFSs), by genome-wide l...
journal_title：Cell
pub_type： 杂志文章,评审
doi：10.1016/j.cell.2013.01.006
更新日期：2013-01-31 00:00:00
abstract：:We have investigated whether histone H1 is present on active Balbiani ring genes in the salivary glands of Chironomus tentans using immunoelectron microscopy. The genes were studied in two activity states: maximally activated genes with a fully extended template and repressed genes in a 30 nm fiber conformation. Histo...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(90)90717-s
更新日期：1990-01-12 00:00:00
abstract：:When transcription regulatory networks are compared among distantly related eukaryotes, a number of striking similarities are observed: a larger-than-expected number of genes, extensive overlapping connections, and an apparently high degree of functional redundancy. It is often assumed that the complexity of these net...
journal_title：Cell
pub_type： 杂志文章,评审
doi：10.1016/j.cell.2015.04.014
更新日期：2015-05-07 00:00:00
abstract：:The mutated gene responsible for the tubby obesity phenotype has been identified by positional cloning. A single base change within a splice donor site results in the incorrect retention of a single intron in the mature tub mRNA transcript. The consequence of this mutation is the substitution of the carboxy-terminal 4...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/s0092-8674(00)81104-6
更新日期：1996-04-19 00:00:00
abstract：:The human immunodeficiency virus, the lentivirus that causes AIDS, is responsible for the most prevalent epidemic in the history of mankind. Here in this Timeline, we have attempted to illustrate a short history of HIV-1, from its identification in landmark papers published by Robert Gallo, Myron Essex, and Luc Montag...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2020.09.004
更新日期：2020-10-15 00:00:00
abstract：:Purified budded virions of Autographa californica nuclear polyhedrosis virus (AcNPV) contain abundant amounts of free ubiquitin, which has an altered electrophoretic mobility on SDS gels as compared with standard ubiquitin. Phase extraction of virion proteins with Triton X-114 indicated that the modified form of ubiqu...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(95)90413-1
更新日期：1995-01-27 00:00:00
abstract：:Mutations in the single-minded (sim) gene of Drosophila result in the loss of the precursor cells giving rise to the midline cells of the embryonic central nervous system. We have examined the structure of the sim product by sequencing a sim cDNA clone, and have also determined the subcellular localization of the prot...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(88)90538-7
更新日期：1988-01-15 00:00:00
abstract：:Studies on several recently discovered error-prone DNA polymerases reveal novel structures that may explain the low fidelity of this general class of enzymes, a number of which are involved in the replicative bypass (translesion synthesis) of base damage in DNA. ...
journal_title：Cell
pub_type： 评论,杂志文章,评审
doi：10.1016/s0092-8674(01)00509-8
更新日期：2001-10-05 00:00:00
abstract：:Intestinal peristalsis is a dynamic physiologic process influenced by dietary and microbial changes. It is tightly regulated by complex cellular interactions; however, our understanding of these controls is incomplete. A distinct population of macrophages is distributed in the intestinal muscularis externa. We demonst...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2014.04.050
更新日期：2014-07-17 00:00:00
abstract：:Xenogeneic spinal cord chimeras were constructed by grafting fragments of quail neural primordium into chick embryos at 2 days of incubation. Hatched birds displayed normal motor behavior for about 5 to 7 weeks, whereupon they developed a neurological syndrome; in the grafted spinal cord the pathological signs of the ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(86)90395-8
更新日期：1986-04-25 00:00:00
abstract：:Metabolic activity is intimately linked to T cell fate and function. Using high-resolution mass spectrometry, we generated dynamic metabolome and proteome profiles of human primary naive T cells following activation. We discovered critical changes in the arginine metabolism that led to a drop in intracellular L-argini...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2016.09.031
更新日期：2016-10-20 00:00:00
abstract：:During adaptive angiogenesis, a key process in the etiology and treatment of cancer and obesity, the vasculature changes to meet the metabolic needs of its target tissues. Although the cues governing vascular remodeling are not fully understood, target-derived signals are generally believed to underlie this process. H...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2013.12.008
更新日期：2014-01-16 00:00:00
abstract：:Prions, self-propagating protein structures that can be transmitted between cells and different organisms, usually consist of ordered protein aggregates. Alberti et al. (2009) now present a systematic approach for the discovery of new prions that expands the spectrum of their biological functions. ...
journal_title：Cell
pub_type： 评论,杂志文章
doi：10.1016/j.cell.2009.03.030
更新日期：2009-04-03 00:00:00
abstract：:The transport kinetics of the influenza virus hemagglutinin from its site of synthesis to the apical plasma membrane of Madin-Darby canine kidney cells, a polarized epithelial cell line, were studied by a sensitive tryptic assay. Hemagglutinin acquired terminal sugars, as judged by sensitivity to endo-beta-N-acetylglu...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(83)90154-x
更新日期：1983-08-01 00:00:00
abstract：:Three different cases of pancreatic beta cell hyperplasia in mice are accompanied by an increase in a subclass of cells expressing tyrosine hydroxylase (TH), a neuronal enzyme. In the nontumorigenic cases of islet growth during normal pregnancy and in the obese mutant mouse, the TH-insulin cells do not divide, in cont...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(88)90534-x
更新日期：1988-01-15 00:00:00
abstract：:A model of hematopoietic development wherein multipotentiality is conserved until segregation of myeloid and lymphoid potential has recently been challenged, proposing that megakaryocyte/erythrocyte (MegE) potential is lost in Flk2/Flt3-expressing early progenitors. Here, we used sensitive in vivo approaches to quanti...
journal_title：Cell
pub_type： 信件
doi：10.1016/j.cell.2006.06.037
更新日期：2006-07-28 00:00:00
abstract：:Advances in genomic technology have produced an explosion of new information about the genetic basis for human disease, fueling extraordinarily high expectations for improved treatments. This perspective will take brief stock of what genetics/genomics have brought to clinical practice to date and what we might expect ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2011.09.013
更新日期：2011-09-30 00:00:00
abstract：:Spinal muscular atrophy (SMA) is an often fatal neuromuscular disease that has been directly linked to the protein product of the Survival of Motor Neurons (SMN) gene. The SMN protein is tightly associated with a novel protein, SIP1, and together they form a complex with several spliceosomal snRNP proteins. Here we sh...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/s0092-8674(00)80368-2
更新日期：1997-09-19 00:00:00
abstract：:Bacteria have evolved many different means of generating movement. In this issue of Cell, Shaevitz et al. (2005) describe the swimming movement of a helical bacterium called Spiroplasma. They discover that Spiroplasma propels itself by generating two temporally distinct kinks that travel the length of the bacterium. T...
journal_title：Cell
pub_type： 评论,杂志文章,评审
doi：10.1016/j.cell.2005.09.003
更新日期：2005-09-23 00:00:00
abstract：:G1-specific transcriptional activation by Cln3/CDK initiates the budding yeast cell cycle. To identify targets of Cln3/CDK, we analyzed the SBF and MBF transcription factor complexes by multidimensional protein interaction technology (MudPIT). Whi5 was identified as a stably bound component of SBF but not MBF. Inactiv...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2004.05.025
更新日期：2004-06-25 00:00:00
abstract：:Molecular chaperones assist protein folding by facilitating their "forward" folding and preventing aggregation. However, once aggregates have formed, these chaperones cannot facilitate protein disaggregation. Bacterial ClpB and its eukaryotic homolog Hsp104 are essential proteins of the heat-shock response, which have...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/s0092-8674(03)00807-9
更新日期：2003-10-17 00:00:00
abstract：:Adult neovascularization relies on the recruitment of circulating cells, but their angiogenic roles and recruitment mechanisms are unclear. We show that the endothelial growth factor VEGF is sufficient for organ homing of circulating mononuclear myeloid cells and is required for their perivascular positioning and rete...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2005.10.036
更新日期：2006-01-13 00:00:00
abstract：:The tumor suppressor PTEN, a critical regulator for multiple cellular processes, is mutated or deleted frequently in various human cancers. Subtle reductions in PTEN expression levels have profound impacts on carcinogenesis. Here we show that PTEN level is regulated by ubiquitin-mediated proteasomal degradation, and p...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2006.11.039
更新日期：2007-01-12 00:00:00
