Histone variants specific to the transcriptionally active, amitotically dividing macronucleus of the unicellular eucaryote, Tetrahymena thermophila.

abstract：:Vertebrate Hoxd genes are sequentially activated during the morphogenesis and pattern formation of the limb. Using the approach of gene disruption via homologous recombination in embryonic stem cells, we have assessed the function of the last gene of the complex, Hoxd-13. Mutant mice displayed skeletal alterations alo...

journal_title：Cell

authors： Dollé P,Dierich A,LeMeur M,Schimmang T,Schuhbaur B,Chambon P,Duboule D

更新日期：1993-11-05 00:00:00

abstract：SUMMARY:Disruption of the cyclin-dependent kinase-inhibitory domain of p27 enhances growth of mice. Growth is attributed to an increase in cell number, due to increased cell proliferation, most obviously in tissues that ordinarily express p27 at the highest levels. Disruption of p27 function leads to nodular hyperplasi...

journal_title：Cell

authors： Kiyokawa H,Kineman RD,Manova-Todorova KO,Soares VC,Hoffman ES,Ono M,Khanam D,Hayday AC,Frohman LA,Koff A

更新日期：1996-05-31 00:00:00

abstract：:We describe automated technologies to probe the structure of neural tissue at nanometer resolution and use them to generate a saturated reconstruction of a sub-volume of mouse neocortex in which all cellular objects (axons, dendrites, and glia) and many sub-cellular components (synapses, synaptic vesicles, spines, spi...

journal_title：Cell

authors： Kasthuri N,Hayworth KJ,Berger DR,Schalek RL,Conchello JA,Knowles-Barley S,Lee D,Vázquez-Reina A,Kaynig V,Jones TR,Roberts M,Morgan JL,Tapia JC,Seung HS,Roncal WG,Vogelstein JT,Burns R,Sussman DL,Priebe CE,Pfister H

更新日期：2015-07-30 00:00:00

abstract：:Cell differentiation is an essential process for the development, growth, reproduction, and longevity of all multicellular organisms, and its regulation has been the focus of intense investigation for the past four decades. The study of natural and induced stem cells has ushered an age of re-examination of what it mea...

journal_title：Cell

authors： Sánchez Alvarado A,Yamanaka S

更新日期：2014-03-27 00:00:00

abstract：:We have determined the nucleotide sequences of the germ line gene as well as a corresponding somatically mutated and rearranged gene coding for a mouse immunoglobulin lambdaI type light chain. These sequencing studies were carried out on three Eco RI-DNA fragments which had been cloned from BALB/c mouse embryos or a l...

journal_title：Cell

authors： Bernard O,Hozumi N,Tonegawa S

更新日期：1978-12-01 00:00:00

abstract：:Nociceptin and its receptor are widely distributed throughout the brain in regions associated with reward behavior, yet how and when they act is unknown. Here, we dissected the role of a nociceptin peptide circuit in reward seeking. We generated a prepronociceptin (Pnoc)-Cre mouse line that revealed a unique subpopula...

journal_title：Cell

authors： Parker KE,Pedersen CE,Gomez AM,Spangler SM,Walicki MC,Feng SY,Stewart SL,Otis JM,Al-Hasani R,McCall JG,Sakers K,Bhatti DL,Copits BA,Gereau RW,Jhou T,Kash TJ,Dougherty JD,Stuber GD,Bruchas MR

更新日期：2019-07-25 00:00:00

abstract：:Fragile X syndrome, a common form of inherited intellectual disability, is caused by loss of the fragile X mental retardation protein FMRP. FMRP is present predominantly in the cytoplasm, where it regulates translation of proteins that are important for synaptic function. We identify FMRP as a chromatin-binding protei...

journal_title：Cell

authors： Alpatov R,Lesch BJ,Nakamoto-Kinoshita M,Blanco A,Chen S,Stützer A,Armache KJ,Simon MD,Xu C,Ali M,Murn J,Prisic S,Kutateladze TG,Vakoc CR,Min J,Kingston RE,Fischle W,Warren ST,Page DC,Shi Y

更新日期：2014-05-08 00:00:00

abstract：:The molecular mediator and functional significance of meal-associated brown fat (BAT) thermogenesis remains elusive. Here, we identified the gut hormone secretin as a non-sympathetic BAT activator mediating prandial thermogenesis, which consequentially induces satiation, thereby establishing a gut-secretin-BAT-brain a...

journal_title：Cell

authors： Li Y,Schnabl K,Gabler SM,Willershäuser M,Reber J,Karlas A,Laurila S,Lahesmaa M,U Din M,Bast-Habersbrunner A,Virtanen KA,Fromme T,Bolze F,O'Farrell LS,Alsina-Fernandez J,Coskun T,Ntziachristos V,Nuutila P,Klingenspor M

更新日期：2018-11-29 00:00:00

abstract：:Cyclic dinucleotides (CDNs) have been previously recognized as important secondary signaling molecules in bacteria and, more recently, in mammalian cells. In the former case, they represent secondary messengers affecting numerous responses of the prokaryotic cell, whereas in the latter, they act as agonists of the inn...

journal_title：Cell

authors： Danilchanka O,Mekalanos JJ

更新日期：2013-08-29 00:00:00

abstract：:Calmodulin is implicated as the primary transducer of the calcium signal in pancreatic beta cells, where it is present at very high concentrations. We have produced three lines of transgenic mice carrying a calmodulin minigene regulated by the rat insulin II promoter. Immunohistochemistry and hybridization analyses in...

journal_title：Cell

authors： Epstein PN,Overbeek PA,Means AR

更新日期：1989-09-22 00:00:00

abstract：:Mutations in gurken and torpedo cause a ventralization in the follicle cell epithelium during Drosophila oogenesis and in the pattern of the embryo that develops in the resultant egg. Both genes lie midway in an epistatic series between fs(1)K10 and dorsal; the mutations block the dorsalization normally observed in K1...

journal_title：Cell

authors： Schüpbach T

更新日期：1987-06-05 00:00:00

abstract：:During metastasis, migrating breast cancer stem cells undergo a loss of polarity leading to an epithelial-to-mesenchymal transition (EMT). Gupta et al. (2009) use this attribute of cancer stem cells to develop a high-throughput screen, which successfully identifies small molecules that specifically inhibit cancer stem...

journal_title：Cell

authors： Beug H

更新日期：2009-08-21 00:00:00

abstract：:The rabbit alpha-globin DNA insertion in the chimeric plasmid pHb 72 (Liu et al., 1977) has been sequenced by the method of Maxam and Gilbert (1977). This has enabled us to determine the messenger RNA(mRNA) sequence beginning in the 5' untranslated region 9 nucleotides before the initiation codon and extending through...

journal_title：Cell

authors： Heindell HC,Liu A,Paddock GV,Studnicka GM,Salser WA

更新日期：1978-09-01 00:00:00

abstract：:The Hippo-YAP pathway regulates organ size by modulating cell proliferation and apoptosis. Yu et al. now reveal that G-protein-coupled receptors act upstream of the transcriptional coactivators YAP/TAZ. This study reinforces the connection between the actin cytoskeleton and Hippo pathway activity and identifies a clas...

journal_title：Cell

authors： Codelia VA,Irvine KD

更新日期：2012-08-17 00:00:00

abstract：:Spindle assembly requires the coordinated action of multiple cellular structures to nucleate and organize microtubules in a precise spatiotemporal manner. Among them, the contributions of centrosomes, chromosomes, and microtubules have been well studied, yet the involvement of membrane-bound organelles remains largely...

journal_title：Cell

authors： Wei JH,Zhang ZC,Wynn RM,Seemann J

更新日期：2015-07-16 00:00:00

abstract：:Metastasis is a rare event. Does it arise from rare, variant, highly metastatic cells or does a primary tumor progress to a premalignant state from which metastases arise stochastically without further changes in gene expression? Arguments and evidence have been adduced to support either position. A paper in this mont...

journal_title：Cell

authors： Hynes RO

更新日期：2003-06-27 00:00:00

abstract：:NF-kappaB, a key regulator of the cellular inflammatory and immune response, is activated by the HTLV-I transforming and transactivating protein Tax. We show that Tax binds to the amino terminus of the protein kinase MEKK1, a component of an IkappaB kinase complex, and stimulates MEKK1 kinase activity. Tax expression ...

journal_title：Cell

authors： Yin MJ,Christerson LB,Yamamoto Y,Kwak YT,Xu S,Mercurio F,Barbosa M,Cobb MH,Gaynor RB

更新日期：1998-05-29 00:00:00

abstract：:Cellular receptors are required for efficient entry of retroviruses into cells. We previously cloned a chicken gene responsible for susceptibility to the retrovirus subgroup A Rous sarcoma virus (RSV(A)). Here we have isolated the quail homolog and generated two alternatively spliced processed genes encoding cellular ...

journal_title：Cell

authors： Bates P,Young JA,Varmus HE

更新日期：1993-09-24 00:00:00

abstract：:An adaptive variant of the human Ectodysplasin receptor, EDARV370A, is one of the strongest candidates of recent positive selection from genome-wide scans. We have modeled EDAR370A in mice and characterized its phenotype and evolutionary origins in humans. Our computational analysis suggests the allele arose in centra...

journal_title：Cell

authors： Kamberov YG,Wang S,Tan J,Gerbault P,Wark A,Tan L,Yang Y,Li S,Tang K,Chen H,Powell A,Itan Y,Fuller D,Lohmueller J,Mao J,Schachar A,Paymer M,Hostetter E,Byrne E,Burnett M,McMahon AP,Thomas MG,Lieberman DE,Jin

更新日期：2013-02-14 00:00:00

abstract：:We have constructed a gene fusion using the promoter of Drosophila hsp70 and the structural gene for Drosophila alcohol dehydrogenase (Adh) and used this construct to transform Adh-deficient flies. In these transformants, Adh is expressed only after heat shock. Like hsp70 itself, this heat-shock-inducible Adh (Adhhs) ...

journal_title：Cell

authors： Bonner JJ,Parks C,Parker-Thornburg J,Mortin MA,Pelham HR

更新日期：1984-07-01 00:00:00

abstract：:The topology of E. coli inner membrane proteins depends primarily on the distribution of positively charged residues in the molecule. We have constructed model proteins with four potential transmembrane stretches and have systematically explored the topological effects of lysines placed in the loops connecting the tra...

journal_title：Cell

authors： Gafvelin G,von Heijne G

更新日期：1994-05-06 00:00:00

abstract：:Forskolin- and cholera toxin-activated adenylate cyclase activity increases between the morula and blastocyst stages of mouse preimplantation development, as assessed by the ability of these agents to increase embryonic cAMP levels. Development of activatable adenylate cyclase requires transcription but is independent...

journal_title：Cell

authors： Manejwala F,Kaji E,Schultz RM

更新日期：1986-07-04 00:00:00

abstract：:Ventral midline cells at different rostrocaudal levels of the central nervous system exhibit distinct properties but share the ability to pattern the dorsoventral axis of the neural tube. We show here that ventral midline cells acquire distinct identities in response to the different signaling activities of underlying...

journal_title：Cell

authors： Dale JK,Vesque C,Lints TJ,Sampath TK,Furley A,Dodd J,Placzek M

更新日期：1997-07-25 00:00:00

abstract：:Most bacteria that colonize eukaryotes must bind directly to host cells to establish a replicative niche. In enteric bacteria, adhesion to host cells is often promoted by a lectin found on surface-localized pili. Some pili promote efficient adhesion only when they are subjected to shear stress, as found during the flo...

journal_title：Cell

authors： Isberg RR,Barnes P

更新日期：2002-07-12 00:00:00

abstract：:To investigate the function of SWI/SNF in site-specific chromatin remodeling at promoters, we have used a purified system to analyze its distribution, function, and retention following recruitment by a sequence-specific transcription activator. Activator recruitment of SWI/SNF bound the complex to promoter proximal nu...

journal_title：Cell

authors： Hassan AH,Neely KE,Workman JL

更新日期：2001-03-23 00:00:00

abstract：:Removal of histone H1 produces a transition in the structure of chromatin fibers as observed by electron microscopy. Chromatin containing all histone proteins appears as fibers with a diameter of about 250 A. The nucleosomes within these fibers are closely packed. If histone H1 is selectively removed with 50-100 mM Na...

journal_title：Cell

authors： Thoma F,Koller T

更新日期：1977-09-01 00:00:00

abstract：:In budding yeast, septins are involved in the morphogenesis checkpoint and the DNA damage checkpoint, both of which regulate cell-cycle progression. In this issue of Cell, Kremer et al. (2007) link septins to DNA damage in mammalian cells by identifying a new signaling pathway that includes the adaptors SOCS7 and NCK....

journal_title：Cell

authors： Kinoshita M,Takeda S

更新日期：2007-09-07 00:00:00

abstract：:Cells released from primary tumors seed metastases to specific organs by a nonrandom process, implying the involvement of biologically selective mechanisms. Based on clinical, functional, and molecular evidence, we show that the cytokine TGFbeta in the breast tumor microenvironment primes cancer cells for metastasis t...

journal_title：Cell

authors： Padua D,Zhang XH,Wang Q,Nadal C,Gerald WL,Gomis RR,Massagué J

更新日期：2008-04-04 00:00:00

abstract：:Poorly immunogenic tumor cells evade host immunity and grow even in the presence of an intact immune system, but the complex mechanisms regulating tumor immunogenicity have not been elucidated. Here, we discovered an unexpected role of the Hippo pathway in suppressing anti-tumor immunity. We demonstrate that, in three...

journal_title：Cell

authors： Moroishi T,Hayashi T,Pan WW,Fujita Y,Holt MV,Qin J,Carson DA,Guan KL

更新日期：2016-12-01 00:00:00

abstract：:Dysfunction and loss of insulin-producing pancreatic beta cells represent hallmarks of diabetes mellitus. Here, we show that mice lacking the mitogen-activated protein kinase (MAPK) p38delta display improved glucose tolerance due to enhanced insulin secretion from pancreatic beta cells. Deletion of p38delta results in...

journal_title：Cell

authors： Sumara G,Formentini I,Collins S,Sumara I,Windak R,Bodenmiller B,Ramracheya R,Caille D,Jiang H,Platt KA,Meda P,Aebersold R,Rorsman P,Ricci R

更新日期：2009-01-23 00:00:00