A chromatin-dependent role of the fragile X mental retardation protein FMRP in the DNA damage response.

abstract：:Three different cases of pancreatic beta cell hyperplasia in mice are accompanied by an increase in a subclass of cells expressing tyrosine hydroxylase (TH), a neuronal enzyme. In the nontumorigenic cases of islet growth during normal pregnancy and in the obese mutant mouse, the TH-insulin cells do not divide, in cont...

journal_title：Cell

authors： Teitelman G,Alpert S,Hanahan D

更新日期：1988-01-15 00:00:00

abstract：:We have examined the conformation of DNA cloned from the hypersensitive region 5' of the chicken adult beta-globin gene, in order to determine whether the unusual sensitivity to nucleases is related to altered secondary structure of the DNA. The region contains a large number of sites for methylation; we have studied ...

journal_title：Cell

authors： Nickol JM,Felsenfeld G

更新日期：1983-12-01 00:00:00

abstract：:We have compared the chromatin structure in the active and inactive states at loci encoding the major heat shock protein in Drosophila. DNAase I and micrococcal nuclease were used as probes of higher order organization and nucleosomal integrity. Such integrity is gauged here by the characteristic pattern of discrete D...

journal_title：Cell

authors： Wu C,Wong YC,Elgin SC

更新日期：1979-04-01 00:00:00

abstract：:During development, neurons switch among growth states, such as initial axon outgrowth, axon pruning, and regrowth. By studying the stereotypic remodeling of the Drosophila mushroom body (MB), we found that the heme-binding nuclear receptor E75 is dispensable for initial axon outgrowth of MB γ neurons but is required ...

journal_title：Cell

authors： Rabinovich D,Yaniv SP,Alyagor I,Schuldiner O

更新日期：2016-01-14 00:00:00

abstract：:The ubiquitin-specific processing protease (UBP) family of deubiquitinating enzymes plays an essential role in numerous cellular processes. HAUSP, a representative UBP, specifically deubiquitinates and hence stabilizes the tumor suppressor protein p53. Here, we report the crystal structures of the 40 kDa catalytic cor...

journal_title：Cell

authors： Hu M,Li P,Li M,Li W,Yao T,Wu JW,Gu W,Cohen RE,Shi Y

更新日期：2002-12-27 00:00:00

abstract：:The nucleotide sequence from the 5' terminus inward of one third of mouse alpha- and beta maj-globin messenger RNAs has been established. In addition, using 5' 32P end-labeled mRNAs as substrates and S1 and T1 nucleases as probes for single-stranded regions, the secondary structures of mouse and rabbit alpha- and beta...

journal_title：Cell

authors： Pavlakis GN,Lockard RE,Vamvakopoulos N,Rieser L,RajBhandary UL,Vournakis JN

更新日期：1980-01-01 00:00:00

abstract：:Embryonal carcinoma cell lines present strong developmental analogies with early embryonic cells. Previous studies have shown that treatment of F9 teratocarcinoma cells with retinoic acid induces the expression of the classical transplantation antigens which are indispensable for effective interactions between cells. ...

journal_title：Cell

authors： Tanaka K,Appella E,Jay G

更新日期：1983-12-01 00:00:00

abstract：:Upon heat shock, Drosophila Kc cells still contain normal cellular messenger RNAs in the cytoplasm. The distribution of these 25 degrees C mRNAs between polysomes and the postpolysomal fraction of heat-shocked cells appears unaltered as compared with control cells. The translatability of these normal cellular messages...

journal_title：Cell

authors： Krüger C,Benecke BJ

更新日期：1981-02-01 00:00:00

abstract：:Specific active transcription units on chromosome IV in the salivary glands of Chironomus tentans have been visualized by the Miller spreading technique and in situ by conventional electron microscopy. These units are likely to be located in the two most conspicuous puffs on chromosome IV, Balbiani ring 1 (BR 1) and B...

journal_title：Cell

authors： Lamb MM,Daneholt B

更新日期：1979-08-01 00:00:00

abstract：:Using insertional mutagenesis, we have isolated a "stalky" mutant in which cells destined to become spores end up as stalk cells. Similar mutants were previously observed after chemical mutagenesis, but the affected gene could not be isolated. Our mutant, like the previous ones, is in stkA. Its defect is cell-autonomo...

journal_title：Cell

authors： Chang WT,Newell PC,Gross JD

更新日期：1996-11-01 00:00:00

abstract：:The membrane-associated carboxypeptidase angiotensin-converting enzyme 2 (ACE2) is an essential regulator of heart function. Now, Li at al. identify and characterize an unexpected second function of ACE2 as a partner of the SARS-CoV spike glycoprotein in mediating virus entry and cell fusion. ...

journal_title：Cell

authors： Dimitrov DS

更新日期：2003-12-12 00:00:00

abstract：:Following EMS mutagenesis we recovered a mutant of D. melanogaster that grows at concentrations of alpha-amanitin lethal to wild-type. To our knowledge this mutant represents the first example of an amanitin-resistant eucaryotic organism. The amanitin resistance of the mutant (AmaC4) is due to an alteration in its DNA...

journal_title：Cell

authors： Greenleaf AL,Borsett LM,Jiamachello PF,Coulter DE

更新日期：1979-11-01 00:00:00

abstract：:Pulmonary neuroendocrine (NE) cells are neurosensory cells sparsely distributed throughout the bronchial epithelium, many in innervated clusters of 20-30 cells. Following lung injury, NE cells proliferate and generate other cell types to promote epithelial repair. Here, we show that only rare NE cells, typically 2-4 p...

journal_title：Cell

authors： Ouadah Y,Rojas ER,Riordan DP,Capostagno S,Kuo CS,Krasnow MA

更新日期：2019-10-03 00:00:00

abstract：:The association of histone modification changes with autism spectrum disorder (ASD) has not been systematically examined. We conducted a histone acetylome-wide association study (HAWAS) by performing H3K27ac chromatin immunoprecipitation sequencing (ChIP-seq) on 257 postmortem samples from ASD and matched control brai...

journal_title：Cell

authors： Sun W,Poschmann J,Cruz-Herrera Del Rosario R,Parikshak NN,Hajan HS,Kumar V,Ramasamy R,Belgard TG,Elanggovan B,Wong CCY,Mill J,Geschwind DH,Prabhakar S

更新日期：2016-11-17 00:00:00

abstract：:Mammalian models of longevity are related primarily to caloric restriction and alterations in metabolism. We examined mice in which type 5 adenylyl cyclase (AC5) is knocked out (AC5 KO) and which are resistant to cardiac stress and have increased median lifespan of approximately 30%. AC5 KO mice are protected from red...

journal_title：Cell

authors： Yan L,Vatner DE,O'Connor JP,Ivessa A,Ge H,Chen W,Hirotani S,Ishikawa Y,Sadoshima J,Vatner SF

更新日期：2007-07-27 00:00:00

abstract：:The endoplasmic reticulum (ER) often forms stacked membrane sheets, an arrangement that is likely required to accommodate a maximum of membrane-bound polysomes for secretory protein synthesis. How sheets are stacked is unknown. Here, we used improved staining and automated ultrathin sectioning electron microscopy meth...

journal_title：Cell

authors： Terasaki M,Shemesh T,Kasthuri N,Klemm RW,Schalek R,Hayworth KJ,Hand AR,Yankova M,Huber G,Lichtman JW,Rapoport TA,Kozlov MM

更新日期：2013-07-18 00:00:00

abstract：:The Origin Recognition Complex (ORC) is a six-protein assembly that specifies the sites of DNA replication initiation in S. cerevisiae. Origin recognition by ORC requires ATP. Here, we demonstrate that two subunits, Orc1p and Orc5p, bind ATP and that Orc1p also hydrolyzes ATP. ATP binding and hydrolysis by Orc1p are b...

journal_title：Cell

authors： Klemm RD,Austin RJ,Bell SP

更新日期：1997-02-21 00:00:00

abstract：:Ions serve as essential nutrients in higher plants and can also act as signaling molecules. Little is known about how plants sense changes in soil nutrient concentrations. Previous studies showed that T101-phosphorylated CHL1 is a high-affinity nitrate transporter, whereas T101-dephosphorylated CHL1 is a low-affinity ...

journal_title：Cell

authors： Ho CH,Lin SH,Hu HC,Tsay YF

更新日期：2009-09-18 00:00:00

abstract：:Recombinant E. coli that produce light were found in a clone library of hybrid plasmids containing DNA from the marine bacterium Vibrio fischeri. All luminescent clones had a 16 kb insert that encoded enzymatic activities for the light reaction as well as regulatory functions necessary for expression of the luminescen...

journal_title：Cell

authors： Engebrecht J,Nealson K,Silverman M

更新日期：1983-03-01 00:00:00

abstract：:We have analyzed the structure of the Shrunken (Sh) locus in a strain containing an unstable recessive mutation, sh-m5933, caused by the transposable controlling element Dissociation (Ds). We have also analyzed nine spontaneous Sh revertant alleles. The sh-m5933 allele contains a 30 kb insertion at the Sh locus, as we...

journal_title：Cell

authors： Courage-Tebbe U,Döring HP,Fedoroff N,Starlinger P

更新日期：1983-09-01 00:00:00

abstract：:The 10Sa RNA, encoded by the E. coli ssrA gene, appears to modulate action of some DNA-binding proteins. When ssrA is inactivated, lacZ expression from the lac operon, as well as galK from a gal operon fused to a phage lambda promoter, is reduced from that observed in bacteria wild-type for ssrA. These differences are...

journal_title：Cell

authors： Retallack DM,Friedman DI

更新日期：1995-10-20 00:00:00

abstract：:In this issue, Wilson et al. (2008) demonstrate that there are two functional subsets of hematopoietic stem cells that have distinctive kinetics of cell cycling. They present evidence that cells may transition between the two kinetic states, establishing one subpopulation that is ready to proliferate and another that ...

journal_title：Cell

authors： Raaijmakers MH,Scadden DT

更新日期：2008-12-12 00:00:00

abstract：:The initiation of chromosome segregation at anaphase is linked by the spindle assembly checkpoint to the completion of chromosome-microtubule attachment during metaphase. To determine the function of the mitotic checkpoint protein Mad2 during normal cell division and when mitosis goes awry, we have knocked out Mad2 in...

journal_title：Cell

authors： Dobles M,Liberal V,Scott ML,Benezra R,Sorger PK

更新日期：2000-06-09 00:00:00

abstract：:By chromosome walking in the major histocompatibility complex (MHC) of the BALB/c mouse, we have linked the K region to the I region at the molecular level. Forty-nine overlapping cosmid clones define a stretch of about 600 kb of DNA containing 2 class I and 7 class II genes. Eleven independent recombination events we...

journal_title：Cell

authors： Steinmetz M,Stephan D,Fischer Lindahl K

更新日期：1986-03-28 00:00:00

abstract：:Fos and Jun transcription factors are induced by a variety of extracellular signaling agents. We describe here an unusual member of the Fos family that is also induced, namely, a truncated form of FosB (delta FosB) missing the C-terminal 101 amino acids of FosB. delta FosB retains the dimerization and DNA-binding acti...

journal_title：Cell

authors： Nakabeppu Y,Nathans D

更新日期：1991-02-22 00:00:00

abstract：:The plant innate immune response includes the hypersensitive response (HR), a form of programmed cell death (PCD). PCD must be restricted to infection sites to prevent the HR from playing a pathologic rather than protective role. Here we show that plant BECLIN 1, an ortholog of the yeast and mammalian autophagy gene A...

journal_title：Cell

authors： Liu Y,Schiff M,Czymmek K,Tallóczy Z,Levine B,Dinesh-Kumar SP

更新日期：2005-05-20 00:00:00

abstract：:Ventral midline cells at different rostrocaudal levels of the central nervous system exhibit distinct properties but share the ability to pattern the dorsoventral axis of the neural tube. We show here that ventral midline cells acquire distinct identities in response to the different signaling activities of underlying...

journal_title：Cell

authors： Dale JK,Vesque C,Lints TJ,Sampath TK,Furley A,Dodd J,Placzek M

更新日期：1997-07-25 00:00:00

abstract：:A major part of virulence for Plasmodium falciparum malaria infection, the most lethal parasitic disease of humans, results from increased rigidity and adhesiveness of infected host red cells. These changes are caused by parasite proteins exported to the erythrocyte using novel trafficking machinery assembled in the h...

journal_title：Cell

authors： Maier AG,Rug M,O'Neill MT,Brown M,Chakravorty S,Szestak T,Chesson J,Wu Y,Hughes K,Coppel RL,Newbold C,Beeson JG,Craig A,Crabb BS,Cowman AF

更新日期：2008-07-11 00:00:00

abstract：:Ríos et al. (2004) report in this issue that the Golgi protein GMAP-210 is sufficient to confer pericentrosomal positioning and recruits gamma-tubulin and associated microtubule-nucleating ring complex proteins to Golgi membranes. The results raise the possibility that short microtubules emanate from the Golgi to medi...

journal_title：Cell

authors： Linstedt AD

更新日期：2004-08-06 00:00:00

abstract：:In 1981, the acquired immunodeficiency syndrome (AIDS) appeared insidiously and mystified doctors and scientists alike. No one could have predicted then that it would become, arguably, the worst plague in human history. Today, 33 million persons are living with infection by the human immunodeficiency virus type 1 (HIV...

journal_title：Cell

authors： Ho DD,Bieniasz PD

更新日期：2008-05-16 00:00:00