Abstract：
:FtsK acts at the bacterial division septum to couple chromosome segregation with cell division. We demonstrate that a truncated FtsK derivative, FtsK(50C), uses ATP hydrolysis to translocate along duplex DNA as a multimer in vitro, consistent with FtsK having an in vivo role in pumping DNA through the closing division septum. FtsK(50C) also promotes a complete Xer recombination reaction between dif sites by switching the state of activity of the XerCD recombinases so that XerD makes the first pair of strand exchanges to form Holliday junctions that are then resolved by XerC. The reaction between directly repeated dif sites in circular DNA leads to the formation of uncatenated circles and is equivalent to the formation of chromosome monomers from dimers.
journal_name
Celljournal_title
Cellauthors
Aussel L,Barre FX,Aroyo M,Stasiak A,Stasiak AZ,Sherratt Ddoi
10.1016/s0092-8674(02)00624-4subject
Has Abstractpub_date
2002-01-25 00:00:00pages
195-205issue
2eissn
0092-8674issn
1097-4172pii
S0092867402006244journal_volume
108pub_type
杂志文章相关文献
CELL文献大全abstract：:The basal ganglia (BG) are critical for adaptive motor control, but the circuit principles underlying their pathway-specific modulation of target regions are not well understood. Here, we dissect the mechanisms underlying BG direct and indirect pathway-mediated control of the mesencephalic locomotor region (MLR), a br...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2015.12.037
更新日期：2016-01-28 00:00:00
abstract：:The spindle pole body (SPB) is the microtubule organizing center (MTOC) in the yeast Saccharomyces that plays a pivotal role in such diverse processes as mitosis, budding, and mating. We have used cryoelectron microscopy and image processing to study the structure of isolated diploid SPBs. We show that SPBs are presen...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/s0092-8674(00)80295-0
更新日期：1997-06-27 00:00:00
abstract：:Resident proteins of the ER lumen carry a specific tetrapeptide signal (KDEL or HDEL) that prevents their secretion. We have previously described the isolation of yeast mutants that fail to retain such resident proteins within the cell. Here we describe ERD2, a gene required for retention. It encodes a 26 kd integral ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(90)90698-e
更新日期：1990-06-29 00:00:00
abstract：:In female mammals a "random choice" mechanism decides which of the two X chromosomes will be inactivated. It has been postulated that Xist is crucial for heterochromatinization and thus functions downstream of the choice mechanism. Here we report that females heterozygous for an internal deletion in the Xist gene, whi...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/s0092-8674(00)81133-2
更新日期：1998-03-06 00:00:00
abstract：:Nontransformed pre-B cells were induced to differentiate in vitro along several different but predictable pathways with only dendritic cells (DC) and concanavalin A-stimulated T lymphocytes. DC-T from spleen induced secretion of only IgM, whereas DC-T from Peyer's patches induced high levels of IgA and intermediate le...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(86)90472-1
更新日期：1986-02-14 00:00:00
abstract：:Pancreatic beta cell-surface expression of glucose transporter 2 (Glut-2) is essential for glucose-stimulated insulin secretion, thereby controlling blood glucose homeostasis in response to dietary intake. We show that the murine GlcNAcT-IVa glycosyltransferase is required for Glut-2 residency on the beta cell surface...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2005.09.041
更新日期：2005-12-29 00:00:00
abstract：:Syntaxin 1A plays a central role in neurotransmitter release through multiple protein-protein interactions. We have used NMR spectroscopy to identify an autonomously folded N-terminal domain in syntaxin 1A and to elucidate its three-dimensional structure. This 120-residue N-terminal domain is conserved in plasma membr...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/s0092-8674(00)81742-0
更新日期：1998-09-18 00:00:00
abstract：:Histone methylation regulates chromatin structure and transcription. The recently identified histone demethylase lysine-specific demethylase 1 (LSD1) is chemically restricted to demethylation of only mono- and di- but not trimethylated histone H3 lysine 4 (H3K4me3). We show that the X-linked mental retardation (XLMR) ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2007.02.017
更新日期：2007-03-23 00:00:00
abstract：:Endogenous and infectious mouse mammary tumor viruses (MMTVs) encode in their 3' long terminal repeat a protein that exerts superantigen activity; that is, it is able to interact with T cells via the variable domain of the T cell receptor (TCR) beta chain. We show here that transmission of an infectious MMTV is preven...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(93)80054-i
更新日期：1993-08-13 00:00:00
abstract：:Protein function is often regulated by posttranslational modifications (PTMs), and recent advances in mass spectrometry have resulted in an exponential increase in PTM identification. However, the functional significance of the vast majority of these modifications remains unknown. To address this problem, we compiled ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2012.05.036
更新日期：2012-07-20 00:00:00
abstract：:Trigger factor is a soluble, 63,000 dalton protein of E. coli that stabilizes proOmpA, the precursor form of a major outer-membrane protein, in a conformation competent for in vitro membrane assembly. There is approximately one trigger factor molecule bound to each 70S ribosome isolated from cell extracts in physiolog...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(88)90116-x
更新日期：1988-09-23 00:00:00
abstract：:Polyglycylation is a posttranslational modification that generates glycine side chains on proteins. Here we identify a family of evolutionarily conserved glycine ligases that modify tubulin using different enzymatic mechanisms. In mammals, two distinct enzyme types catalyze the initiation and elongation steps of polyg...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2009.05.020
更新日期：2009-06-12 00:00:00
abstract：:Serotonin is a highly ubiquitous signaling molecule that plays a role in the regulation of various physiological functions. Several lines of evidence, including the present work from Hsiao and colleagues, demonstrate that, in the gut, microbial-derived metabolites affect the production of serotonin that in turn impact...
journal_title：Cell
pub_type： 评论,杂志文章
doi：10.1016/j.cell.2015.03.033
更新日期：2015-04-09 00:00:00
abstract：:Neurotrophic factors are essential for neuronal survival and function. Recent data have demonstrated that the product of the tyrosine kinase trk proto-oncogene binds NGF and is a component of the high affinity NGF receptor. Analysis of the trkB gene product, gp145trkB, in NIH 3T3 cells indicates that this tyrosine kin...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(91)90396-g
更新日期：1991-05-31 00:00:00
abstract：:RNA-guided Cas9 endonucleases protect bacteria from viral infection and have been creatively repurposed as programmable molecular scalpels for surgical manipulation of DNA. Now, two papers in Cell (Pawluk et al. and Rauch et al.) identify viral proteins that suppress Cas9 and may function like molecular sheaths for th...
journal_title：Cell
pub_type： 评论,杂志文章
doi：10.1016/j.cell.2016.12.007
更新日期：2017-01-12 00:00:00
abstract：:Synaptotagmin is one of the major integral membrane proteins of synaptic vesicles. It has been postulated to dock vesicles to their release sites, to act as the Ca2+ sensor for the release process, and to be a fusion protein during exocytosis. To clarify the function of this protein, we have undertaken a genetic analy...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(93)90356-u
更新日期：1993-07-02 00:00:00
abstract：:Toxic DNA-protein crosslinks (DPCs) arise by ionizing irradiation and UV light, are particularly caused by endogenously produced reactive compounds such as formaldehyde, and also occur during compromised topoisomerase action. Although nucleotide excision repair and homologous recombination contribute to cell survival ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2014.04.053
更新日期：2014-07-17 00:00:00
abstract：:Mammals can taste a wide repertoire of chemosensory stimuli. Two unrelated families of receptors (T1Rs and T2Rs) mediate responses to sweet, amino acids, and bitter compounds. Here, we demonstrate that knockouts of TRPM5, a taste TRP ion channel, or PLCbeta2, a phospholipase C selectively expressed in taste tissue, ab...
journal_title：Cell
pub_type： 评论,杂志文章
doi：10.1016/s0092-8674(03)00071-0
更新日期：2003-02-07 00:00:00
abstract：:Treatment of guinea pig neutrophils with pertussis toxin (islet-activating protein; IAP) results in inhibition of N-formyl peptide receptor-mediated release of arachidonic acid and granular enzymes. Inhibition by the toxin is specific, in that responses to the calcium ionophore A23187 are not affected. The action of t...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(84)90008-4
更新日期：1984-12-01 00:00:00
abstract：:A comprehensive analysis uncovered a set of yeast proteins promoting protein-based inheritance that shares many of the non-Mendelian properties of prions. Lacking any sequence or structural signatures of known prions, these proteins represent a new class of non-amyloid, protein-based epigenetic determinants that can c...
journal_title：Cell
pub_type： 杂志文章,评审
doi：10.1016/j.cell.2016.09.036
更新日期：2016-10-06 00:00:00
abstract：:Childhood asthma is typically associated with a polarized Th2 response to inhaled allergens and is influenced by genetics. Yang et al. show that the asthma susceptibility gene DENND1B controls cytokine production in Th2 lymphocytes by controlling the rate of TCR internalization and routing to endosomes, providing a mo...
journal_title：Cell
pub_type： 评论,杂志文章
doi：10.1016/j.cell.2015.12.045
更新日期：2016-01-14 00:00:00
abstract：:Junctions that connect the endoplasmic reticulum (ER) and the plasma membrane (PM) are unique yet ubiquitous subcellular compartments. Giordano et al. now report that extended synaptotagmins (E-Syts) promote their formation, providing fundamental insight into the molecular machinery controlling ER and plasma membrane ...
journal_title：Cell
pub_type： 评论,杂志文章
doi：10.1016/j.cell.2013.05.054
更新日期：2013-06-20 00:00:00
abstract：:The mitochondrial RNA binding proteins MRP1 and MRP2 form a heteromeric complex that functions in kinetoplastid RNA editing. In this process, MRP1/MRP2 serves as a matchmaker by binding to guide RNAs and facilitating their hybridization with cognate preedited mRNAs. To understand the mechanism by which this complex pe...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2006.06.047
更新日期：2006-08-25 00:00:00
abstract：:Periodic transcription of yeast histone genes has been demonstrated by DNA excess filter hybridization of in vivo pulse-labeled RNA isolated from synchronous cell cultures. Using strains carrying cell division cycle (cdc) mutations, we show that both activation and termination of transcription are determined by tempor...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(82)90036-8
更新日期：1982-08-01 00:00:00
abstract：:The plant innate immune response includes the hypersensitive response (HR), a form of programmed cell death (PCD). PCD must be restricted to infection sites to prevent the HR from playing a pathologic rather than protective role. Here we show that plant BECLIN 1, an ortholog of the yeast and mammalian autophagy gene A...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2005.03.007
更新日期：2005-05-20 00:00:00
abstract：:Pure primary mesenchymal cells from definitive streak stage chick embryos have been prepared free of epiblast and hypoblast cells. These cells have the potential in culture to differentiate into erythroid cells, beating heart muscle tissue, chondrocytes and epithelial cells. Transformation in vitro of pure primary mes...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(79)90320-9
更新日期：1979-08-01 00:00:00
abstract：:A growing body of evidence indicates that plant transcription factors move between cells. A recent paper by Nakajima et al. (2001) shows that movement of the SHORTROOT protein provides a mechanism for signaling positional information between cell layers of the root. ...
journal_title：Cell
pub_type： 杂志文章,评审
doi：10.1016/s0092-8674(01)00532-3
更新日期：2001-10-19 00:00:00
abstract：:The rabbit alpha-globin DNA insertion in the chimeric plasmid pHb 72 (Liu et al., 1977) has been sequenced by the method of Maxam and Gilbert (1977). This has enabled us to determine the messenger RNA(mRNA) sequence beginning in the 5' untranslated region 9 nucleotides before the initiation codon and extending through...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(78)90081-8
更新日期：1978-09-01 00:00:00
abstract：:The mipA gene of A. nidulans encodes a newly discovered member of the tubulin superfamily of proteins, gamma-tubulin. In A. nidulans, gamma-tubulin is essential for nuclear division and microtubule assembly and is associated with the spindle pole body, the fungal microtubule organizing center. By low stringency hybrid...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(91)90389-g
更新日期：1991-05-31 00:00:00
abstract：:The monoclonal antibody ECCD-1 inhibits Ca2+-dependent cell-cell adhesion in teratocarcinoma cells, recognizing a cell surface component of MW 124,000. When mouse embryos at various preimplantation stages were cultured in the presence of ECCD-1, the compacted morphology of the 8- to 16-cell-stage embryos was destroyed...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(83)90095-8
更新日期：1983-12-01 00:00:00
