Abstract:
:Transduction of cellular genes by retroviruses requires two recombinations: one to form the left-hand junction between cellular gene and viral genome, the other to form the right-hand junction. Previous findings raised the possibility that the right-hand recombination might use RNA molecules as intermediates. We now provide direct experimental support for this view by showing that the right-hand end of v-fps in the avian sarcoma virus PRCII was formed by recombination within the poly(A) tract at the 3' end of the mRNA for the proto-oncogene c-fps. Recombination of this sort may be mediated by "copy-choice" during reverse transcription, acting on either homologous or non-homologous nucleotide sequences.
journal_name
Celljournal_title
Cellauthors
Huang CC,Hay N,Bishop JMdoi
10.1016/0092-8674(86)90016-4subject
Has Abstractpub_date
1986-03-28 00:00:00pages
935-40issue
6eissn
0092-8674issn
1097-4172pii
0092-8674(86)90016-4journal_volume
44pub_type
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