The timing of developmental transitions in plants.

abstract：:Treating B16 mouse melanoma cells with monoclonal antibody NORM-2 reduces cell growth in tissue culture, agar, and syngeneic mice. We show that the NORM-2 antibody recognizes an integral 83 kd glycoprotein that is mobile in the plane of the plasma membrane of B16 melanoma cells. Expression of the glycoprotein is reduc...

journal_title：Cell

authors： Wieland I,Müller G,Braun S,Birchmeier W

更新日期：1986-12-05 00:00:00

abstract：:Mutations at the X-linked disconnected locus of D. melanogaster lead to the failure of adult photoreceptor axons to innervate their target cells in the developing optic lobes of the third instar larva, resulting in flies that have rudimentary optic ganglia. The cascade of epigenetic events leading to the adult disconn...

journal_title：Cell

authors： Steller H,Fischbach KF,Rubin GM

更新日期：1987-09-25 00:00:00

abstract：:DNA transcription, replication, and repair are regulated by histone acetylation, a process that requires the generation of acetyl-coenzyme A (CoA). Here, we show that all the subunits of the mitochondrial pyruvate dehydrogenase complex (PDC) are also present and functional in the nucleus of mammalian cells. We found t...

journal_title：Cell

authors： Sutendra G,Kinnaird A,Dromparis P,Paulin R,Stenson TH,Haromy A,Hashimoto K,Zhang N,Flaim E,Michelakis ED

更新日期：2014-07-03 00:00:00

abstract：:Intestinal peristalsis is a dynamic physiologic process influenced by dietary and microbial changes. It is tightly regulated by complex cellular interactions; however, our understanding of these controls is incomplete. A distinct population of macrophages is distributed in the intestinal muscularis externa. We demonst...

journal_title：Cell

authors： Muller PA,Koscsó B,Rajani GM,Stevanovic K,Berres ML,Hashimoto D,Mortha A,Leboeuf M,Li XM,Mucida D,Stanley ER,Dahan S,Margolis KG,Gershon MD,Merad M,Bogunovic M

更新日期：2014-07-17 00:00:00

abstract：:In prokaryotes, the toxin-antitoxin systems are thought to play important roles in growth regulation under stress conditions. In the E. coli MazE-MazF system, MazF toxin functions as an mRNA interferase cleaving mRNAs at ACA sequences to inhibit protein synthesis leading to cell growth arrest. Myxococcus xanthus is a ...

journal_title：Cell

authors： Nariya H,Inouye M

更新日期：2008-01-11 00:00:00

abstract：:Recombinant DNA techniques have been used to isolate the integrated viral DNA, together with flanking cellular sequences, from three independently isolated lines of SV40-transformed BALB/c 3T3 cells. We have determined the structures of these cloned segments and their relationships to one another by restriction enzyme...

journal_title：Cell

authors： Clayton CE,Rigby PW

更新日期：1981-08-01 00:00:00

abstract：:Coated vesicles isolated from rat liver perfused with diisopropylfluorophosphate (DFP) to inactivate endogenous cholinesterase contained newly synthesized secretory cholinesterase after a 30 min recovery. The cholinesterase is found in coated vesicles of presumed endocytic origin following DFP treatment and perfusion ...

journal_title：Cell

authors： Helmy S,Porter-Jordan K,Dawidowicz EA,Pilch P,Schwartz AL,Fine RE

更新日期：1986-02-14 00:00:00

abstract：:ATP-dependent proteases are vital to maintain cellular protein homeostasis. Here, we study the mechanisms of force generation and intersubunit coordination in the ClpXP protease from E. coli to understand how these machines couple ATP hydrolysis to mechanical protein unfolding. Single-molecule analyses reveal that pho...

journal_title：Cell

authors： Sen M,Maillard RA,Nyquist K,Rodriguez-Aliaga P,Pressé S,Martin A,Bustamante C

更新日期：2013-10-24 00:00:00

abstract：:The switch from membrane-bound to secreted-form IgM that occurs during differentiation of B lymphocytes has long been known to involve regulated processing of the heavy chain pre-mRNA. Here, we show that accumulation of one subunit of an essential polyadenylation factor (CstF-64) is specifically repressed in mouse pri...

journal_title：Cell

authors： Takagaki Y,Seipelt RL,Peterson ML,Manley JL

更新日期：1996-11-29 00:00:00

abstract：:Aging entails a progressive decline in protein homeostasis, which often leads to age-related diseases. The endoplasmic reticulum (ER) is the site of protein synthesis and maturation for secreted and membrane proteins. Correct folding of ER proteins requires covalent attachment of N-linked glycan oligosaccharides. Here...

journal_title：Cell

authors： Denzel MS,Storm NJ,Gutschmidt A,Baddi R,Hinze Y,Jarosch E,Sommer T,Hoppe T,Antebi A

更新日期：2014-03-13 00:00:00

abstract：:During the SOS response, LexA repressor is inactivated by specific cleavage. Although cleavage requires RecA protein in vivo, RecA acts indirectly as a coprotease by stimulating an inherent self-cleavage activity of LexA. In lambda lysogens, cleavage of lambda Cl repressor in a similar but far slower reaction results ...

journal_title：Cell

authors： Kim B,Little JW

更新日期：1993-06-18 00:00:00

abstract：:The chromosomal distributions of five families of mouse r-protein genes (S16, L18, L19, L30 and L32/33) were studied by Southern blot analysis of DNa from a panel of mouse-hamster hybrid cells containing various complements of mouse chromosomes. Our results indicated that members of a particular family are often locat...

journal_title：Cell

authors： D'Eustachio P,Meyuhas O,Ruddle F,Perry RP

更新日期：1981-05-01 00:00:00

abstract：:Basal cells are by definition located on the basolateral side of several epithelia, and they have never been observed reaching the lumen. Using high-resolution 3D confocal imaging, we report that basal cells extend long and slender cytoplasmic projections that not only reach toward the lumen but can cross the tight ju...

journal_title：Cell

authors： Shum WW,Da Silva N,McKee M,Smith PJ,Brown D,Breton S

更新日期：2008-12-12 00:00:00

abstract：:Certain mutant alleles at the low density lipoprotein (LDL) receptor locus produce receptors that bind LDL normally, but fail to cluster in coated pits and therefore cannot transport LDL into cells. We prepared genomic DNA libraries from cells of two individuals with this phenotype (internalization-defective familial ...

journal_title：Cell

authors： Lehrman MA,Goldstein JL,Brown MS,Russell DW,Schneider WJ

更新日期：1985-07-01 00:00:00

abstract：:The chaperonin GroEL binds nonnative proteins too large to fit inside the productive GroEL-GroES cis cavity, but whether and how it assists their folding has remained unanswered. We have examined yeast mitochondrial aconitase, an 82 kDa monomeric Fe(4)S(4) cluster-containing enzyme, observed to aggregate in chaperonin...

journal_title：Cell

authors： Chaudhuri TK,Farr GW,Fenton WA,Rospert S,Horwich AL

更新日期：2001-10-19 00:00:00

abstract：:The Bcl-2 family proteins are key regulators of apoptosis in human diseases and cancers. Though known to block apoptosis, Bcl-2 promotes cell death through an undefined mechanism. Here, we show that Bcl-2 interacts with orphan nuclear receptor Nur77 (also known as TR3), which is required for cancer cell apoptosis indu...

journal_title：Cell

authors： Lin B,Kolluri SK,Lin F,Liu W,Han YH,Cao X,Dawson MI,Reed JC,Zhang XK

更新日期：2004-02-20 00:00:00

abstract：:We have investigated whether histone H1 is present on active Balbiani ring genes in the salivary glands of Chironomus tentans using immunoelectron microscopy. The genes were studied in two activity states: maximally activated genes with a fully extended template and repressed genes in a 30 nm fiber conformation. Histo...

journal_title：Cell

authors： Ericsson C,Grossbach U,Björkroth B,Daneholt B

更新日期：1990-01-12 00:00:00

abstract：:The phenotype of the autosomal recessive mutation scat includes severe intermittent bleeding, depletion of platelets, and circulating anti-platelet antibodies. In this study, we have mapped the scat mutation to mouse chromosome 8 and shown that the immune component is a secondary consequence of the gene defect. Surpri...

journal_title：Cell

authors： Peters LL,Barker JE

更新日期：1993-07-16 00:00:00

abstract：:P-selectin binding to neutrophils requires a specific protein, P-selectin glycoprotein ligand 1 (PSGL-1), as well as sialyl-Lewis X (sLex) glycan determinants. We have found that a short segment near the amino terminus of PSGL-1 that contains a tyrosine sulfation consensus is essential for P-selectin adhesion and that...

journal_title：Cell

authors： Pouyani T,Seed B

更新日期：1995-10-20 00:00:00

abstract：:A "switch" from oxidative phosphorylation (OXPHOS) to aerobic glycolysis is a hallmark of T cell activation and is thought to be required to meet the metabolic demands of proliferation. However, why proliferating cells adopt this less efficient metabolism, especially in an oxygen-replete environment, remains incomplet...

journal_title：Cell

authors： Chang CH,Curtis JD,Maggi LB Jr,Faubert B,Villarino AV,O'Sullivan D,Huang SC,van der Windt GJ,Blagih J,Qiu J,Weber JD,Pearce EJ,Jones RG,Pearce EL

更新日期：2013-06-06 00:00:00

abstract：:During early Drosophila embryogenesis, several zygotic gene products act to establish a posttranscriptional activity gradient of the morphogen DPP. Among these molecules, Tolloid, a putative metalloprotease related to BMP-1, enhances DPP function, while SOG, an ortholog of the Xenopus organizer Chordin, inhibits DPP f...

journal_title：Cell

authors： Marqués G,Musacchio M,Shimell MJ,Wünnenberg-Stapleton K,Cho KW,O'Connor MB

更新日期：1997-10-31 00:00:00

abstract：:HIV release requires TSG101, a cellular factor that sorts proteins into vesicles that bud into multivesicular bodies (MVB). To test whether other proteins involved in MVB biogenesis (the class E proteins) also participate in HIV release, we identified 22 candidate human class E proteins. These proteins were connected ...

journal_title：Cell

authors： von Schwedler UK,Stuchell M,Müller B,Ward DM,Chung HY,Morita E,Wang HE,Davis T,He GP,Cimbora DM,Scott A,Kräusslich HG,Kaplan J,Morham SG,Sundquist WI

更新日期：2003-09-19 00:00:00

abstract：:A mutation in any one of eight spoO genes of Bacillus subtilis blocks the process of spore formation at its earliest stage. To investigate how the products of the spoO genes may be involved in developmental gene expression, we fused the lacZ gene of E. coli to spoVG, a sporulation gene whose induction at the onset of ...

journal_title：Cell

authors： Zuber P,Losick R

更新日期：1983-11-01 00:00:00

abstract：:The coactivator PGC-1alpha is a key regulator of mitochondrial biogenesis and respiration, mediating expression of several transcription factors required for these programs. Three new studies reveal that PGC-1alpha expression is downregulated in patients with Huntington's disease (HD) and in several animal models of t...

journal_title：Cell

authors： McGill JK,Beal MF

更新日期：2006-11-03 00:00:00

abstract：:The trk tyrosine kinase proto-oncogene product gp140prototrk binds nerve growth factor (NGF) and is rapidly and selectively activated by this neurotrophic factor. To determine whether gp140prototrk is involved in transducing a functional NGF signal, PC12 cell mutants (PC12nnr) deficient in high affinity NGF binding an...

journal_title：Cell

authors： Loeb DM,Maragos J,Martin-Zanca D,Chao MV,Parada LF,Greene LA

更新日期：1991-09-06 00:00:00

abstract：:The yeast SIR2 gene is involved in regulating nucleosome phasing and transcription in the mating type system. We have found that SIR2 also plays another important role in the cell. Specifically, in wild-type SIR2 strains recombination between the tandemly repeated ribosomal RNA genes is depressed. In sir2 mutants, bot...

journal_title：Cell

authors： Gottlieb S,Esposito RE

更新日期：1989-03-10 00:00:00

abstract：:Chronic viral infections represent a major burden to human health, and modulation of the immune system is emerging as a novel approach to fighting such infections. Pellegrini et al. (2011) demonstrate that treatment with the cytokine IL-7 may reinvigorate the immune response to persistent infection by targeting immuno...

journal_title：Cell

authors： Parish IA,Kaech SM

更新日期：2011-02-18 00:00:00

abstract：:A safe and controlled manipulation of endocytosis in vivo may have disruptive therapeutic potential. Here, we demonstrate that the anti-emetic/anti-psychotic prochlorperazine can be repurposed to reversibly inhibit the in vivo endocytosis of membrane proteins targeted by therapeutic monoclonal antibodies, as directly ...

journal_title：Cell

authors： Chew HY,De Lima PO,Gonzalez Cruz JL,Banushi B,Echejoh G,Hu L,Joseph SR,Lum B,Rae J,O'Donnell JS,Merida de Long L,Okano S,King B,Barry R,Moi D,Mazzieri R,Thomas R,Souza-Fonseca-Guimaraes F,Foote M,McCluskey A,Robin

更新日期：2020-03-05 00:00:00

abstract：:In the nucleus of eukaryotic cells, RNA decay in the 3'-5' direction is carried out by a complex of exonucleases called the exosome. Surprisingly, the purified exosome shows only weak activity in vitro. Two papers in this issue of Cell, by LaCava et al. (2005) and Wyers et al. (2005), and a third report by Vanacova et...

journal_title：Cell

authors： Jensen TH,Moore C

更新日期：2005-06-03 00:00:00

abstract：:An attenuated form of familial adenomatous polyposis coli, AAPC, causes relatively few colonic polyps, but still carries a significant risk of colon cancer. The mutant alleles responsible for this attenuated phenotype have been mapped in several families to the adenomatous polyposis coli (APC) locus on human chromosom...

journal_title：Cell

authors： Spirio L,Olschwang S,Groden J,Robertson M,Samowitz W,Joslyn G,Gelbert L,Thliveris A,Carlson M,Otterud B

更新日期：1993-12-03 00:00:00