Scrapie prion protein contains a phosphatidylinositol glycolipid.

abstract：:Axonal transport has been intensively examined as a good model for studying the mechanism of organelle transport in cells, but it is still unclear how different types of membrane organelles are transported through the nerve axon. To elucidate the function of this mechanism, we have cloned KIF1A, a novel neuron-specifi...

journal_title：Cell

authors： Okada Y,Yamazaki H,Sekine-Aizawa Y,Hirokawa N

更新日期：1995-06-02 00:00:00

abstract：:The symmetric core of the nuclear pore complex can be considered schematically as a series of concentric cylinders. A peripheral cylinder coating the pore membrane contains the previously characterized, elongated heptamer that harbors Sec13-Nup145C in its middle section. Strikingly, Sec13-Nup145C crystallizes as a het...

journal_title：Cell

authors： Hsia KC,Stavropoulos P,Blobel G,Hoelz A

更新日期：2007-12-28 00:00:00

abstract：:The protein product of the human Duchenne muscular dystrophy locus (DMD) and its mouse homolog (mDMD) have been identified by using polyclonal antibodies directed against fusion proteins containing two distinct regions of the mDMD cDNA. The DMD protein is shown to be approximately 400 kd and to represent approximately...

journal_title：Cell

authors： Hoffman EP,Brown RH Jr,Kunkel LM

更新日期：1987-12-24 00:00:00

abstract：:We describe here a bizarre organization of the single large subunit (LSU) and small subunit (SSU) rRNA genes in the mitochondrial DNA of Chlamydomonas reinhardtii. Each gene is discontinuous, with gene pieces encoding specific rRNA domains ("modules") interspersed with one another and with intact protein coding and tR...

journal_title：Cell

authors： Boer PH,Gray MW

更新日期：1988-11-04 00:00:00

abstract：:Pure primary mesenchymal cells from definitive streak stage chick embryos have been prepared free of epiblast and hypoblast cells. These cells have the potential in culture to differentiate into erythroid cells, beating heart muscle tissue, chondrocytes and epithelial cells. Transformation in vitro of pure primary mes...

journal_title：Cell

authors： Keane RW,Lindblad PC,Pierik LT,Ingram VM

更新日期：1979-08-01 00:00:00

abstract：:In familial searching in forensic genetics, a query DNA profile is tested against a database to determine whether it represents a relative of a database entrant. We examine the potential for using linkage disequilibrium to identify pairs of profiles as belonging to relatives when the query and database rely on nonover...

journal_title：Cell

authors： Kim J,Edge MD,Algee-Hewitt BFB,Li JZ,Rosenberg NA

更新日期：2018-10-18 00:00:00

abstract：:A gene, bcl-3, is found on chromosome 19 adjacent to the breakpoints in the translocation t(14;19)(q32;q13.1), which occurs in some cases of chronic lymphocytic leukemia. Sequence analysis of the human bcl-3 gene predicts a protein containing seven tandem copies of the SWI6/cdc10 motif. This motif was previously ident...

journal_title：Cell

authors： Ohno H,Takimoto G,McKeithan TW

更新日期：1990-03-23 00:00:00

abstract：:The sequences corresponding to the 18S and 28S rRNAs have been mapped within a cloned 17 kilobase (kb) fragment formed by Eco R1 cleavage of Drosophila melanogaster rDNA. This fragment, Dm103, represents the longer of two major types of repeating units that are present in the rDNA of this fly, and was cloned as a hybr...

journal_title：Cell

authors： Glover DM,Hogness DS

更新日期：1977-02-01 00:00:00

abstract：:Mutations in the Drosophila maternal genes plutonium (plu) and pan gu (png) have the striking phenotype that DNA replication initiates in unfertilized eggs. Fertilized eggs from plu or png mutant mothers also have a mutant phenotype; DNA replication is uncoupled from nuclear division, resulting in giant, polyploid nuc...

journal_title：Cell

authors： Shamanski FL,Orr-Weaver TL

更新日期：1991-09-20 00:00:00

abstract：:Resident proteins of the ER lumen carry a specific tetrapeptide signal (KDEL or HDEL) that prevents their secretion. We have previously described the isolation of yeast mutants that fail to retain such resident proteins within the cell. Here we describe ERD2, a gene required for retention. It encodes a 26 kd integral ...

journal_title：Cell

authors： Semenza JC,Hardwick KG,Dean N,Pelham HR

更新日期：1990-06-29 00:00:00

abstract：:The global rise in the prevalence of obesity and associated co-morbidities such as type 2 diabetes, cardiovascular disease, and cancer represents a major public health concern. The biological response to increased consumption of palatable foods or a reduction in energy expenditure is highly variable between individual...

journal_title：Cell

authors： van der Klaauw AA,Farooqi IS

更新日期：2015-03-26 00:00:00

abstract：:xol-1 is the earliest-acting gene in the known hierarchy that controls C. elegans sex determination and dosage compensation. We show that the primary sex-determining signal (the X/A ratio) directs the choice of sexual fate by regulating xol-1 transcript levels: high xol-1 expression during gastrulation triggers male d...

journal_title：Cell

authors： Rhind NR,Miller LM,Kopczynski JB,Meyer BJ

更新日期：1995-01-13 00:00:00

abstract：:Sterol regulatory element binding proteins (SREBPs) are transcription factors attached to the endoplasmic reticulum. The NH2-segment, which activates transcription, is connected to membranes by a hairpin anchor formed by two transmembrane sequences and a short lumenal loop. Using H-Ras-SREBP-2 fusion proteins, we show...

journal_title：Cell

authors： Sakai J,Duncan EA,Rawson RB,Hua X,Brown MS,Goldstein JL

更新日期：1996-06-28 00:00:00

abstract：:Two papers published in 1984 by the Varshavsky laboratory revealed that the ubiquitin/proteasome pathway is the principal system for degradation of short-lived proteins in mammalian cells, setting the stage for future demonstrations of this pathway's many regulatory roles. This perspective discusses the impact of thos...

journal_title：Cell

authors： Pickart CM

更新日期：2004-01-23 00:00:00

abstract：:Inductive signals cause conversion of mesenchyme into epithelia during the formation of many organs. Yet a century of study has not revealed the inducing molecules. Using a standard model of induction, we found that ureteric bud cells secrete factors that convert kidney mesenchyme to epithelia that, remarkably, then f...

journal_title：Cell

authors： Barasch J,Yang J,Ware CB,Taga T,Yoshida K,Erdjument-Bromage H,Tempst P,Parravicini E,Malach S,Aranoff T,Oliver JA

更新日期：1999-11-12 00:00:00

abstract：:Spotted fever group (SFG) rickettsiae are human pathogens that infect cells in the vasculature. They disseminate through host tissues by a process of cell-to-cell spread that involves protrusion formation, engulfment, and vacuolar escape. Other bacterial pathogens rely on actin-based motility to provide a physical for...

journal_title：Cell

authors： Lamason RL,Bastounis E,Kafai NM,Serrano R,Del Álamo JC,Theriot JA,Welch MD

更新日期：2016-10-20 00:00:00

abstract：:The functions of caveolae, the characteristic plasma membrane invaginations, remain debated. Their abundance in cells experiencing mechanical stress led us to investigate their role in membrane-mediated mechanical response. Acute mechanical stress induced by osmotic swelling or by uniaxial stretching results in a rapi...

journal_title：Cell

authors： Sinha B,Köster D,Ruez R,Gonnord P,Bastiani M,Abankwa D,Stan RV,Butler-Browne G,Vedie B,Johannes L,Morone N,Parton RG,Raposo G,Sens P,Lamaze C,Nassoy P

更新日期：2011-02-04 00:00:00

abstract：:Histone DNA of Psammechinus miliaris was obtained in an enriched form by buoyant density gradient centrifugation and was cleaved into 6 kb repeat units (Birnstiel et al., 1975a) by the action of the specific endonucleases EcoRI and HindIII. Since it was suspected that the 6 kb unit harbored all five histone-coding seq...

journal_title：Cell

authors： Schaffner W,Gross K,Telford J,Birnstiel M

更新日期：1976-08-01 00:00:00

abstract：:Brown and beige adipocytes are specialized cells that express uncoupling protein 1 (UCP1) and dissipate chemical energy as heat. These cells likely possess alternative UCP1-independent thermogenic mechanisms. Here, we identify a secreted enzyme, peptidase M20 domain containing 1 (PM20D1), that is enriched in UCP1(+) v...

journal_title：Cell

authors： Long JZ,Svensson KJ,Bateman LA,Lin H,Kamenecka T,Lokurkar IA,Lou J,Rao RR,Chang MR,Jedrychowski MP,Paulo JA,Gygi SP,Griffin PR,Nomura DK,Spiegelman BM

更新日期：2016-07-14 00:00:00

abstract：:The microtubule-based metaphase spindle is subjected to forces that act in diverse orientations and over a wide range of timescales. Currently, we cannot explain how this dynamic structure generates and responds to forces while maintaining overall stability, as we have a poor understanding of its micromechanical prope...

journal_title：Cell

authors： Shimamoto Y,Maeda YT,Ishiwata S,Libchaber AJ,Kapoor TM

更新日期：2011-06-24 00:00:00

abstract：:To reconstruct modern human evolutionary history and identify loci that have shaped hunter-gatherer adaptation, we sequenced the whole genomes of five individuals in each of three different hunter-gatherer populations at > 60× coverage: Pygmies from Cameroon and Khoesan-speaking Hadza and Sandawe from Tanzania. We ide...

journal_title：Cell

authors： Lachance J,Vernot B,Elbers CC,Ferwerda B,Froment A,Bodo JM,Lema G,Fu W,Nyambo TB,Rebbeck TR,Zhang K,Akey JM,Tishkoff SA

更新日期：2012-08-03 00:00:00

abstract：:In nearly every organism studied, reduced caloric intake extends life span. In yeast, span extension from dietary restriction is thought to be mediated by the highly conserved, nutrient-responsive target of rapamycin (TOR), protein kinase A (PKA), and Sch9 kinases. These kinases coordinately regulate various cellular ...

journal_title：Cell

authors： Steffen KK,MacKay VL,Kerr EO,Tsuchiya M,Hu D,Fox LA,Dang N,Johnston ED,Oakes JA,Tchao BN,Pak DN,Fields S,Kennedy BK,Kaeberlein M

更新日期：2008-04-18 00:00:00

abstract：:Subcellular compartments in which folding and assembly of proteins occur seem to have a set of PCB proteins capable of mediating these and related processes, such as translocation across membranes. When a domain of a polypeptide chain emerges from a ribosome during synthesis or from the distal side of a membrane durin...

journal_title：Cell

authors： Rothman JE

更新日期：1989-11-17 00:00:00

abstract：:The non-receptor protein tyrosine phosphatase (PTP) SHP2, encoded by PTPN11, plays an essential role in RAS-mitogen-activated protein kinase (MAPK) signaling during normal development. It has been perplexing as to why both enzymatically activating and inactivating mutations in PTPN11 result in human developmental diso...

journal_title：Cell

authors： Zhu G,Xie J,Kong W,Xie J,Li Y,Du L,Zheng Q,Sun L,Guan M,Li H,Zhu T,He H,Liu Z,Xia X,Kan C,Tao Y,Shen HC,Li D,Wang S,Yu Y,Yu ZH,Zhang ZY,Liu C,Zhu J

更新日期：2020-10-15 00:00:00

abstract：:The structure of the complex formed by the arginine-rich motif of the transcriptional antitermination protein N of phage lambda and boxB RNA was determined by heteronuclear magnetic resonance spectroscopy. A bent alpha helix in N recognizes primarily the shape and negatively charged surface of the boxB hairpin through...

journal_title：Cell

authors： Legault P,Li J,Mogridge J,Kay LE,Greenblatt J

更新日期：1998-04-17 00:00:00

abstract：:We demonstrate that mutations in the human Ca(2+)-sensing receptor gene cause familial hypocalciuric hypercalcemia (FHH) and neonatal severe hyperparathyroidism (NSHPT), two inherited conditions characterized by altered calcium homeostasis. The Ca(2+)-sensing receptor belongs to the superfamily of seven membrane-spann...

journal_title：Cell

authors： Pollak MR,Brown EM,Chou YH,Hebert SC,Marx SJ,Steinmann B,Levi T,Seidman CE,Seidman JG

更新日期：1993-12-31 00:00:00

abstract：:How and when memory T cells form during an immune response are long-standing questions. To better understand memory CD8 T cell development, a time course of gene expression and functional changes in antigen-specific T cells during viral infection was evaluated. The expression of many genes continued to change after vi...

journal_title：Cell

authors： Kaech SM,Hemby S,Kersh E,Ahmed R

更新日期：2002-12-13 00:00:00

abstract：:Cadherins are a group of homophilic intercellular adhesion molecules; each member of this family exhibits binding specificity. Here, we attempted to map the sites for the specificities of these molecules by analyzing adhesives selectivities of the cells that express chimeric and point-mutated E- and P-cadherin. The re...

journal_title：Cell

authors： Nose A,Tsuji K,Takeichi M

更新日期：1990-04-06 00:00:00

abstract：:Toll-like receptors (TLRs) are membrane-bound sensors that detect and respond to microbial infection. Two studies in Cell, one in this issue, reveal how TLRs recognize their ligands. Kim et al. (2007) recently reported the structure of TLR4 bound to the accessory protein MD-2 and its antagonist, the drug eritoran. In ...

journal_title：Cell

authors： Brodsky I,Medzhitov R

更新日期：2007-09-21 00:00:00

abstract：:In this study, we have located the sites of transcription initiation and termination on a cloned fragment of ribosomal DNA from X. laevis, and have sequenced the surrounding nucleotides. As reported previously (Reeder, Sollner-Webb and Wahn, 1977), about 25% of the 40S rRNA precursor molecules isolated from oocytes ha...

journal_title：Cell

authors： Sollner-Webb B,Reeder RH

更新日期：1979-10-01 00:00:00