Abstract：
:In a 4-cell stage C. elegans embryo, signaling by the P2 blastomere induces anterior-posterior polarity in the adjacent EMS blastomere, leading to endoderm formation. We have taken genetic and reverse genetic approaches toward understanding the molecular basis for this induction. These studies have identified a set of genes with sequence similarity to genes that have been shown to be, or are implicated in, Wnt/Wingless signaling pathways in other systems. The C. elegans genes described here are related to wnt/wingless, porcupine, frizzled, beta-catenin/armadillo, and the human adenomatous polyposis coli gene, APC. We present evidence that there may be partially redundant inputs into endoderm specification and that a subset of these genes appear also to function in determining cytoskeletal polarity in certain early blastomeres.
journal_name
Celljournal_title
Cellauthors
Rocheleau CE,Downs WD,Lin R,Wittmann C,Bei Y,Cha YH,Ali M,Priess JR,Mello CCdoi
10.1016/s0092-8674(00)80531-0subject
Has Abstractpub_date
1997-08-22 00:00:00pages
707-16issue
4eissn
0092-8674issn
1097-4172pii
S0092-8674(00)80531-0journal_volume
90pub_type
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