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Lateral and axial signals involved in avian somite patterning: a role for BMP4.

Abstract：

:In vertebrates, muscles of the limbs and body wall derive from the lateral compartment of the embryonic somites, and axial muscles derive from the medial compartment. Whereas the mechanisms that direct patterning of somites along the dorsoventral axis are beginning to be understood, little is known about the tissue interactions and signaling molecules that direct somite patterning along the mediolateral axis. We report the identification of a specific marker for the lateral somitic compartment and its early derivatives, cSim1, an avian homolog of the Drosophila single minded gene. Using this marker, we provide evidence that specification of the lateral somitic lineage results from the antagonistic actions of a diffusible medializing signal from the neural tube and a diffusible lateralizing signal from the lateral plate mesoderm, and we implicate bone morphogenetic protein 4(BMP4) in directing this lateralization.

journal_name

Cell

journal_title

Cell

authors

Pourquié O,Fan CM,Coltey M,Hirsinger E,Watanabe Y,Bréant C,Francis-West P,Brickell P,Tessier-Lavigne M,Le Douarin NM

doi

10.1016/s0092-8674(00)81291-x

subject

Has Abstract

pub_date

1996-02-09 00:00:00

pages

461-71

issue

3

eissn

0092-8674

issn

1097-4172

pii

S0092-8674(00)81291-X

journal_volume

84

pub_type

杂志文章

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