Abstract：
:We have tested a model for global ribosome biosynthesis by examining the effects of increased gene dosage on the synthesis of rRNA. Increasing gene dosage does not lead to a significant increase in total rRNA transcription; i.e., rRNA synthesis from individual rRNA operons is reduced to keep total rRNA production unchanged. In contrast, when the plasmid-encoded rRNA operons used to increase gene dosage contain deletions within the rRNA coding region, rRNA transcription is gene-dosage-dependent; i.e., rRNA regulation is relieved. We find that the syntheses of most, if not all, tRNAs are also subject to the same controls as rRNA transcription. We conclude that the production of functional rRNA is monitored by the regulatory system that controls rRNA and tRNA transcription. We propose that rRNA and tRNA are negatively controlled by products of rRNA operons and discuss evidence suggesting that ribosomes are the key element involved in the postulated feedback regulation.
journal_name
Celljournal_title
Cellauthors
Jinks-Robertson S,Gourse RL,Nomura Mdoi
10.1016/0092-8674(83)90029-6subject
Has Abstractpub_date
1983-07-01 00:00:00pages
865-76issue
3eissn
0092-8674issn
1097-4172pii
0092-8674(83)90029-6journal_volume
33pub_type
杂志文章相关文献
CELL文献大全abstract：:Phosphoinositide 3-kinases (PI3-Ks) are an important emerging class of drug targets, but the unique roles of PI3-K isoforms remain poorly defined. We describe here an approach to pharmacologically interrogate the PI3-K family. A chemically diverse panel of PI3-K inhibitors was synthesized, and their target selectivity...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2006.03.035
更新日期：2006-05-19 00:00:00
abstract：:Regeneration of transected peripheral nerves is a complex process involving the coordinated action of neuronal axons, glial cells, and fibroblasts. Using rodent models of nerve repair, Parrinello et al. (2010) find that ephrin signaling between fibroblasts and Schwann cell progenitors, involving the stemness factor So...
journal_title：Cell
pub_type： 评论,杂志文章
doi：10.1016/j.cell.2010.09.018
更新日期：2010-10-01 00:00:00
abstract：:The adaptive immune system is important for control of most viral infections. The three fundamental components of the adaptive immune system are B cells (the source of antibodies), CD4+ T cells, and CD8+ T cells. The armamentarium of B cells, CD4+ T cells, and CD8+ T cells has differing roles in different viral infect...
journal_title：Cell
pub_type： 杂志文章,评审
doi：10.1016/j.cell.2021.01.007
更新日期：2021-01-12 00:00:00
abstract：:The actin-filled stereocilia of cochlear hair cells deflect in response to sound by pivoting around rootlets at their insertion points at the sensory cell surface. Kitajiri et al. (2010) now show that the actin-binding protein TRIOBP tightly bundles the actin filaments into rootlets, endowing these stereocilia "pivots...
journal_title：Cell
pub_type： 评论,杂志文章
doi：10.1016/j.cell.2010.05.022
更新日期：2010-05-28 00:00:00
abstract：:Enveloped viruses enter cells by inducing fusion of viral and cellular membranes, a process catalyzed by a specialized membrane-fusion protein expressed on their surface. This review focuses on recent structural studies of viral fusion proteins with an emphasis on their metastable prefusion form and on interactions wi...
journal_title：Cell
pub_type： 杂志文章,评审
doi：10.1016/j.cell.2018.02.054
更新日期：2018-03-08 00:00:00
abstract：:We have identified a nuclear pathway that rapidly degrades unspliced pre-mRNAs in yeast. This involves 3'-->5' degradation by the exosome complex and 5'-->3' degradation by the exonuclease Rat1p. 3'-->5' degradation is normally the major pathway and is regulated in response to carbon source. Inhibition of pre-mRNA deg...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/s0092-8674(00)00065-9
更新日期：2000-09-15 00:00:00
abstract：:Metabolic conditions affect the developmental tempo of animals. Developmental gene regulatory networks (GRNs) must therefore synchronize their dynamics with a variable timescale. We find that layered repression of genes couples GRN output with variable metabolism. When repressors of transcription or mRNA and protein s...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2019.06.023
更新日期：2019-08-08 00:00:00
abstract：:The microtubule-based metaphase spindle is subjected to forces that act in diverse orientations and over a wide range of timescales. Currently, we cannot explain how this dynamic structure generates and responds to forces while maintaining overall stability, as we have a poor understanding of its micromechanical prope...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2011.05.038
更新日期：2011-06-24 00:00:00
abstract：:Amid growing recognition that a successful scientific career requires skills beyond scientific acumen, institutions are racing to provide management training for newly minted principal investigators. ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2008.03.008
更新日期：2008-03-21 00:00:00
abstract：:The Eph receptor tyrosine kinase family is regulated by autophosphorylation within the juxtamembrane region and the kinase activation segment. We have solved the X-ray crystal structure to 1.9 A resolution of an autoinhibited, unphosphorylated form of EphB2 comprised of the juxtamembrane region and the kinase domain. ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/s0092-8674(01)00496-2
更新日期：2001-09-21 00:00:00
abstract：:Rho and rac, two members of the ras-related superfamily of small GTPases, regulate the polymerization of actin to produce stress fibers and lamellipodia, respectively. We report here that cdc42, another member of the rho family, triggers the formation of a third type of actin-based structure found at the cell peripher...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(95)90370-4
更新日期：1995-04-07 00:00:00
abstract：:Centrosomes are non-membrane-bound compartments that nucleate microtubule arrays. They consist of nanometer-scale centrioles surrounded by a micron-scale, dynamic assembly of protein called the pericentriolar material (PCM). To study how PCM forms a spherical compartment that nucleates microtubules, we reconstituted P...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2017.05.028
更新日期：2017-06-01 00:00:00
abstract：:In Drosophila gonads, Piwi proteins and associated piRNAs collaborate with additional factors to form a small RNA-based immune system that silences mobile elements. Here, we analyzed nine Drosophila piRNA pathway mutants for their impacts on both small RNA populations and the subcellular localization patterns of Piwi ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2009.03.040
更新日期：2009-05-01 00:00:00
abstract：:Nuclear DNA from eucaryotes contains a significant fraction which forms duplexes very rapidly and also independently of the DNA concentration. This fraction can be isolated by adsorption to hydroxylapatite and has been called foldback DNA (Britten and Smith, 1970). Here we extend previous studies to show that the fold...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(76)90182-3
更新日期：1976-05-01 00:00:00
abstract：:X inactivation results in inactivation of one X chromosome to compensate for gene dosage differences between mammalian females and males. It requires the X-inactivation center (Xic) and Xist in cis. We report that introducing 450 kb of murine Xic/Xist sequences onto autosomes activates female dosage compensation in ma...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/s0092-8674(00)80079-3
更新日期：1996-07-12 00:00:00
abstract：:Motor neurons stimulate their postsynaptic muscle targets to synthesize neurotransmitter receptors. Polypeptide signaling molecules may mediate this inductive interaction. Here we report the purification of ARIA, a protein that stimulates the synthesis of muscle acetylcholine receptors, and the isolation of ARIA cDNA....
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(93)90407-h
更新日期：1993-03-12 00:00:00
abstract：:Lymphocyte migration is essential for adaptive immune surveillance. However, our current understanding of this process is rudimentary, because most human studies have been restricted to immunological analyses of blood and various tissues. To address this knowledge gap, we used an integrated approach to characterize ti...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2020.11.019
更新日期：2020-12-23 00:00:00
abstract：:The ongoing pandemic of a new human coronavirus, SARS-CoV-2, has generated enormous global concern. We and others in China were involved in the initial genome sequencing of the virus. Herein, we describe what genomic data reveal about the emergence SARS-CoV-2 and discuss the gaps in our understanding of its origins. ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2020.03.035
更新日期：2020-04-16 00:00:00
abstract：:Using cryo-electron microscopy, we have solved the structure of an icosidodecahedral COPII coat involved in cargo export from the endoplasmic reticulum (ER) coassembled from purified cargo adaptor Sec23-24 and Sec13-31 lattice-forming complexes. The coat structure shows a tetrameric assembly of the Sec23-24 adaptor la...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2008.06.024
更新日期：2008-08-08 00:00:00
abstract：:Sonic hedgehog (Shh) signaling from the posterior zone of polarizing activity (ZPA) is the primary determinant of anterior-posterior polarity in the vertebrate limb field. An active signal is produced by an autoprocessing reaction that covalently links cholesterol to the N-terminal signaling moiety (N-Shh(p)), tetheri...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/s0092-8674(01)00369-5
更新日期：2001-06-01 00:00:00
abstract：:The short chain aliphatic acid salts, butyrate and propionate, are effective inhibitors of histone deacetylation in chick oviduct at 2--5 mM; they also prevent the hormonal induction of the ovalbumin and transferrin genes. The less potent deacetylase inhibitor isobutyrate is correspondingly less effective in blocking ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(80)90357-8
更新日期：1980-11-01 00:00:00
abstract：:Cadherins are a group of homophilic intercellular adhesion molecules; each member of this family exhibits binding specificity. Here, we attempted to map the sites for the specificities of these molecules by analyzing adhesives selectivities of the cells that express chimeric and point-mutated E- and P-cadherin. The re...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(90)90222-z
更新日期：1990-04-06 00:00:00
abstract：:The influence of MHC antigens on TCR gamma delta usage in CD8+ intraepithelial lymphocytes (IELs) was examined using a pan-reactive and V delta 4 region-specific MAb. While an average of 30% of IELs from the majority of mice of various MHC haplotypes were V delta 4+, a 2-fold or greater percentage of IELs from H-2k mi...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(90)90166-c
更新日期：1990-10-19 00:00:00
abstract：:Every day we make decisions critical for adaptation and survival. We repeat actions with known consequences. But we also draw on loosely related events to infer and imagine the outcome of entirely novel choices. These inferential decisions are thought to engage a number of brain regions; however, the underlying neuron...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2020.08.035
更新日期：2020-10-01 00:00:00
abstract：:DNA fragments containing the silencers that flank the mating type genes at HML alpha are shown to bind specifically to the nuclear scaffold of yeast. The scaffold proteins are solubilized with urea and then renatured to form a soluble extract which allows reconstitution of sequence-specific DNA loops. At the silent ma...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(89)90788-5
更新日期：1989-06-02 00:00:00
abstract：:We have produced a series of somatic cell hybrids by fusing pluripotent PCC4aza1 embryonal carcinoma ("teretocarcinoma") cells with thymocytes from young adult mice. When these hybrids form tumors in nu/nu or syngeneic mice, all the tumors contain a range of differentiated tissues, as well as embryonal carcinoma-like ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(76)90051-9
更新日期：1976-09-01 00:00:00
abstract：:The pluripotential hemopoietic stem cells (CFU-S) of genetically resistant Fv2rr adult C57BL/6 (B6) mice can be persistently infected by Friend virus (FV) when exposed to defective spleen focus-forming virus (SFFV) and helper virus (LLV) at the time of transplantation into heavily irradiated syngeneic recipients (that...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(82)90327-0
更新日期：1982-12-01 00:00:00
abstract：:The assembly of COPI into a cage-like lattice sculpts membrane vesicles that transport cargo from the Golgi apparatus. Now, Lee and Goldberg (2010) present X-ray crystal structures of COPI suggesting that these coats combine selected features of two other archetypal coats, clathrin and COPII. ...
journal_title：Cell
pub_type： 评论,杂志文章
doi：10.1016/j.cell.2010.06.031
更新日期：2010-07-09 00:00:00
abstract：:Developing cells of the cellular slime mold Dictyostelium discoideum release a low molecular weight metabolite (Slug Turning Factor, STF) which, at high uniform concentrations, interferes with phototaxis and thermotaxis by D. discoideum slugs. D. discoideum slugs migrating in darkness are repelled by (exhibit negative...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(81)90444-x
更新日期：1981-03-01 00:00:00
abstract：:We have characterized regulation of a complex Chlamydomonas reinhardtii chloroplast (PA) whose activity is stimulated by the DNA gyrase inhibitor novobiocin, both in the alga itself and in a heterologous Escherichia coli plasmid system. Since novobiocin is known to reduce torsional stress in E. coli DNA, we interpret ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(87)90431-4
更新日期：1987-01-30 00:00:00
