New telomere formation after developmentally regulated chromosomal breakage during the process of chromatin diminution in Ascaris lumbricoides.

Abstract:

:During the process of chromatin diminution, which takes place in all presomatic cells of the early Ascaris embryo, the heterochromatic termini of the chromosomes are lost. Here we show that the newly formed ends of the reduced somatic chromosomes carry tandem repeats of the telomeric sequence TTAGGC. Comparison of a cloned somatic telomere with the corresponding germline chromosomal region revealed that these telomeric repeats are not present at or near the chromosomal breakage site. They are most likely added by a telomerase-mediated event. Chromosomal breakage, which precedes the telomere addition process, takes place within a short, specific chromosomal region (CBR); however, it does not occur at a single locus, but rather at many different sites. Altogether, our data show that chromatin diminution in Ascaris is a complex molecular process that includes site-specific chromosomal breakage, new telomere formation, and DNA degradation.

journal_name

Cell

journal_title

Cell

authors

Müller F,Wicky C,Spicher A,Tobler H

doi

10.1016/0092-8674(91)90076-b

subject

Has Abstract

pub_date

1991-11-15 00:00:00

pages

815-22

issue

4

eissn

0092-8674

issn

1097-4172

pii

0092-8674(91)90076-B

journal_volume

67

pub_type

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