Abstract:
:During the process of chromatin diminution, which takes place in all presomatic cells of the early Ascaris embryo, the heterochromatic termini of the chromosomes are lost. Here we show that the newly formed ends of the reduced somatic chromosomes carry tandem repeats of the telomeric sequence TTAGGC. Comparison of a cloned somatic telomere with the corresponding germline chromosomal region revealed that these telomeric repeats are not present at or near the chromosomal breakage site. They are most likely added by a telomerase-mediated event. Chromosomal breakage, which precedes the telomere addition process, takes place within a short, specific chromosomal region (CBR); however, it does not occur at a single locus, but rather at many different sites. Altogether, our data show that chromatin diminution in Ascaris is a complex molecular process that includes site-specific chromosomal breakage, new telomere formation, and DNA degradation.
journal_name
Celljournal_title
Cellauthors
Müller F,Wicky C,Spicher A,Tobler Hdoi
10.1016/0092-8674(91)90076-bsubject
Has Abstractpub_date
1991-11-15 00:00:00pages
815-22issue
4eissn
0092-8674issn
1097-4172pii
0092-8674(91)90076-Bjournal_volume
67pub_type
杂志文章相关文献
CELL文献大全abstract::The mTOR Complex 1 (mTORC1) pathway regulates cell growth in response to numerous cues, including amino acids, which promote mTORC1 translocation to the lysosomal surface, its site of activation. The heterodimeric RagA/B-RagC/D GTPases, the Ragulator complex that tethers the Rags to the lysosome, and the v-ATPase form...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2012.07.032
更新日期:2012-09-14 00:00:00
abstract::In 1981, the acquired immunodeficiency syndrome (AIDS) appeared insidiously and mystified doctors and scientists alike. No one could have predicted then that it would become, arguably, the worst plague in human history. Today, 33 million persons are living with infection by the human immunodeficiency virus type 1 (HIV...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2008.05.003
更新日期:2008-05-16 00:00:00
abstract::Nine transcripts complementary to mouse L cell mitochondrial DNA have been detected, sized and mapped to restriction fragments using the method of Berk and Sharp (1977). RNA isolated from L cell mitochondria was hybridized to 32P-labeled, cloned L cell mitochondrial DNA restriction fragments in 70% formamide under con...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(78)90309-4
更新日期:1978-05-01 00:00:00
abstract::H2S is an endogenous gasotransmitter that plays an important role in physiological conditions. In this issue, Das et al. provide evidence that SIRT1-dependent angiogenesis is augmented by H2S-findings reinforced by Longchamp et al., who demonstrate that H2S-dependent angiogenesis is triggered by amino acid deprivation...
journal_title:Cell
pub_type: 评论,杂志文章
doi:10.1016/j.cell.2018.03.011
更新日期:2018-03-22 00:00:00
abstract::We have isolated five clones containing human histone genes from a human genomic DNA library, using a cloned X. laevis histone H4 cDNA probe (pX1ch4). Each genomic clone has been mapped and the locations of the histone genes have been determined by blot hybridization and hybridization-selection of human histone mRNA. ...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(81)90092-1
更新日期:1981-06-01 00:00:00
abstract::The karyophilic properties of the viral matrix (MA) protein govern HIV nuclear import in nondividing cells such as macrophages. A critical regulator of this process is the C-terminal tyrosine phosphorylation of MA during virus maturation. Here, we reveal the mechanism of this phenomenon, by demonstrating that tyrosine...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(95)90097-7
更新日期:1995-11-17 00:00:00
abstract::Spatiotemporal changes in nuclear lamina composition underlie cell-type-specific chromatin organization and cell fate, suggesting that the lamina forms a dynamic framework critical for genome function, cellular identity, and developmental potential. ...
journal_title:Cell
pub_type: 杂志文章,评审
doi:10.1016/j.cell.2013.02.052
更新日期:2013-03-14 00:00:00
abstract::Meiotic cohesin serves in sister chromatid linkage and DNA repair until its subunit Rec8 is cleaved by separase. Separase is activated when its inhibitor, securin, is polyubiquitinated by the Cdc20 regulated anaphase-promoting complex (APC(Cdc20)) and consequently degraded. Differently regulated APCs (APC(Cdh1), APC(A...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2005.01.017
更新日期:2005-03-25 00:00:00
abstract::The precursor of the 55K adenovirus terminal protein is an 87K protein that is covalently linked to viral DNA. This protein is likely to be identical to the 80,000 dalton protein described by Challberg et al. (1980). The mRNA for the 87K terminal protein precursor, like that for the E2-72K DNA binding protein, is dete...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(81)90145-8
更新日期:1981-02-01 00:00:00
abstract::The genetics of complex disease produce alterations in the molecular interactions of cellular pathways whose collective effect may become clear through the organized structure of molecular networks. To characterize molecular systems associated with late-onset Alzheimer's disease (LOAD), we constructed gene-regulatory ...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2013.03.030
更新日期:2013-04-25 00:00:00
abstract::Proteolytic fragments of human plasma fibronectin were used to identify monoclonal antibodies reacting with the various domains of fibronectin. One of these antibodies, which reacts with cell-attachment-promoting fragments of fibronectin, inhibits attachment of cells to fibronectin-coated surfaces. A cell-attachment-p...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(81)90308-1
更新日期:1981-10-01 00:00:00
abstract::Protein function is often regulated by posttranslational modifications (PTMs), and recent advances in mass spectrometry have resulted in an exponential increase in PTM identification. However, the functional significance of the vast majority of these modifications remains unknown. To address this problem, we compiled ...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2012.05.036
更新日期:2012-07-20 00:00:00
abstract::Social isolation is a stressful condition that often leads to maladaptive behaviors. In this issue of Cell, Zelikowsky et al. find that chronic social isolation stress triggers an increase in neuronal tachykinin signaling across distinct brain regions that mediate fear and aggression, elucidating the neural basis of t...
journal_title:Cell
pub_type: 评论,杂志文章
doi:10.1016/j.cell.2018.04.031
更新日期:2018-05-17 00:00:00
abstract::An approach to identify backbone conformational changes underlying nicotinic acetylcholine receptor (nAChR) gating was developed. Specific backbone peptide bonds were replaced with an ester, which disrupts backbone hydrogen bonds at the site of mutation. At a conserved proline residue (alphaPro221) in the first transm...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/s0092-8674(00)80962-9
更新日期:1999-01-08 00:00:00
abstract::In Xenopus development, the expression of several maternal mRNAs is regulated by cytoplasmic polyadenylation. CPEB and maskin, two factors that control polyadenylation-induced translation are present on the mitotic apparatus of animal pole blastomeres in embryos. Cyclin B1 protein and mRNA, whose translation is regula...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/s0092-8674(00)00135-5
更新日期:2000-10-27 00:00:00
abstract::Autophagy is a catabolic process in which lysosomes degrade intracytoplasmic contents transported in double-membraned autophagosomes. Autophagosomes are formed by the elongation and fusion of phagophores, which can be derived from preautophagosomal structures coming from the plasma membrane and other sites like the en...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2011.06.023
更新日期:2011-07-22 00:00:00
abstract::Genetic analyses in Drosophila have demonstrated that the multipass membrane protein Smoothened (Smo) is essential for all Hedgehog signaling. We show that Smo acts epistatic to Ptc1 to mediate Shh and Ihh signaling in the early mouse embryo. Smo and Shh/Ihh compound mutants have identical phenotypes: embryos fail to ...
journal_title:Cell
pub_type: 杂志文章
doi:
更新日期:2001-06-15 00:00:00
abstract::While mutations affecting protein-coding regions have been examined across many cancers, structural variants at the genome-wide level are still poorly defined. Through integrative deep whole-genome and -transcriptome analysis of 101 castration-resistant prostate cancer metastases (109X tumor/38X normal coverage), we i...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2018.06.039
更新日期:2018-07-26 00:00:00
abstract::Through dissecting the link between spatial genome organization and DNA replication timing, Sima et al. (2018) discover early replicating control elements (ERCEs), a new type of cis-acting elements that regulate replication timing, transcription, and multiple layers of three-dimensional features of genome organization...
journal_title:Cell
pub_type: 评论,杂志文章
doi:10.1016/j.cell.2019.01.027
更新日期:2019-02-07 00:00:00
abstract::Nucleotide sequences in two wild-type and six mutant operators in the DNA of phage lambda are compared. Strikingly similar 17 base pair units are found which we identify as the repressor binding sites. Each operator contains multiple repressor binding sites separated by A-T rich spacers. Elements of 2 fold rotational ...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(75)90018-5
更新日期:1975-06-01 00:00:00
abstract::Members of the myocyte enhancer factor-2 (MEF2) family of MADS domain transcription factors cannot induce myogenesis in transfected fibroblasts, but when coexpressed with the myogenic basic-helix-loop-helix (bHLH) proteins MyoD or myogenin they dramatically increase the extent of myogenic conversion above that seen wi...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(95)90139-6
更新日期:1995-12-29 00:00:00
abstract::The membrane-bound form of immunoglobulin serves as an antigen-specific receptor for B cells mediating signal transduction and antigen presentation. We have developed an assay that reconstitutes both these physiologic responses with respect to the antigen phosphorylcholine. By introducing specific mutations in the hum...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(90)90171-a
更新日期:1990-10-19 00:00:00
abstract::The steroid hormone ecdysone triggers coordinate changes in Drosophila tissue development that result in metamorphosis. To advance our understanding of the genetic regulatory hierarchies controlling this tissue response, we have isolated and characterized a gene, EcR, for a new steroid receptor homolog and have shown ...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(91)90572-g
更新日期:1991-10-04 00:00:00
abstract::ROAM mutations cause overproduction in S. cerevisiae. Overproduction of ROAM mutant gene products is less in MATa/MAT alpha diploid strains which cannot conjugate than in haplolid strains which can. Overproduction occurs in diploid strains capable of mating whether or not they are capable of sporulating. Overproductio...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(80)90353-0
更新日期:1980-11-01 00:00:00
abstract::Expression of human immunodeficiency virus type 1 structural proteins requires both the viral Rev trans-activator and its cis-acting RNA target sequence, the Rev response element (RRE). The RRE has been mapped to a conserved region of the HIV-1 env gene and is predicted to form a complex, highly stable RNA stem-loop s...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(90)90670-a
更新日期:1990-02-23 00:00:00
abstract::DNA transposition has contributed significantly to evolution of eukaryotes and prokaryotes. Insertion sequences (ISs) are the simplest prokaryotic transposons and are divided into families on the basis of their organization and transposition mechanism. Here, we describe a link between transposition of IS608 and ISDra2...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2010.06.034
更新日期:2010-08-06 00:00:00
abstract::Metabolic activity is intimately linked to T cell fate and function. Using high-resolution mass spectrometry, we generated dynamic metabolome and proteome profiles of human primary naive T cells following activation. We discovered critical changes in the arginine metabolism that led to a drop in intracellular L-argini...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2016.09.031
更新日期:2016-10-20 00:00:00
abstract::We have cloned the C. elegans cell death gene ced-3. A ced-3 transcript is most abundant during embryogenesis, the stage during which most programmed cell deaths occur. The predicted CED-3 protein shows similarity to human and murine interleukin-1 beta-converting enzyme and to the product of the mouse nedd-2 gene, whi...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(93)90485-9
更新日期:1993-11-19 00:00:00
abstract::Different hematopoietic cells produce minute amounts of beta-related interferon (IFN) following induction of differentiation by chemical or natural inducers. The endogenous IFN binds to type I cell surface receptors and modulates gene expression in the producer cells. We show that self-induction of two members of the ...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(86)90857-3
更新日期:1986-07-04 00:00:00
abstract::Chemical modifications of histones and DNA, such as histone methylation, histone acetylation, and DNA methylation, play critical roles in epigenetic gene regulation. Many of the enzymes that add or remove such chemical modifications are known, or might be suspected, to be sensitive to changes in intracellular metaboli...
journal_title:Cell
pub_type: 杂志文章,评审
doi:10.1016/j.cell.2013.03.004
更新日期:2013-03-28 00:00:00