DNAase I encapsulated in liposomes can induce neoplastic transformation of Syrian hamster embryo cells in culture.

abstract：:Posttranslational modifications control microtubule behavior, yet assigning roles to particular signals was hampered by lack of defined in vitro systems. In this issue of Cell, Valenstein and Roll-Mecak establish a biochemical platform to interrogate consequences of microtubule polyglutamylation, thereby providing imp...

journal_title：Cell

authors： Schaletzky J,Rape M

更新日期：2016-02-25 00:00:00

abstract：:In this issue of Cell, a study by Valerie Mizrahi and her colleagues suggests that a putative error-prone DNA polymerase encoded by the dnaE2 gene of Mycobacterium tuberculosis may bypass certain types of DNA base damage, generating mutations. This may be an important mechanism for generating drug-resistant strains of...

journal_title：Cell

authors： Friedberg EC,Fischhaber PL

更新日期：2003-04-18 00:00:00

abstract：:Recent results from diverse organisms point to a self-reinforcing network of interactions among the three best-characterized covalent modifications that mark heterochromatin: histone hypoacetylation, histone H3-Lys9 methylation, and cytosine methylation. These modification systems suggest a mechanistic basis for sprea...

journal_title：Cell

authors： Richards EJ,Elgin SC

更新日期：2002-02-22 00:00:00

abstract：:Initiator tRNAs from the cytoplasm of salmon testes and salmon liver have been purified. The nucleotide sequence of these initiator tRNAs has been determined and found identical to that of initiator tRNA from mammalian cytoplasm. The only difference is the extent of modification of the nuceloside located between the d...

journal_title：Cell

authors： Gillum AM,Urquhart N,Smith M,RajBhandary UL

更新日期：1975-11-01 00:00:00

abstract：:In Drosophila gonads, Piwi proteins and associated piRNAs collaborate with additional factors to form a small RNA-based immune system that silences mobile elements. Here, we analyzed nine Drosophila piRNA pathway mutants for their impacts on both small RNA populations and the subcellular localization patterns of Piwi ...

journal_title：Cell

authors： Malone CD,Brennecke J,Dus M,Stark A,McCombie WR,Sachidanandam R,Hannon GJ

更新日期：2009-05-01 00:00:00

abstract：:Transfer RNA (tRNA) gene content is a differentiating feature of genomes that contributes to the efficiency of the translational apparatus, but the principles shaping tRNA gene copy number and codon composition are poorly understood. Here, we report that the emergence of two specific tRNA modifications shaped the stru...

journal_title：Cell

authors： Novoa EM,Pavon-Eternod M,Pan T,Ribas de Pouplana L

更新日期：2012-03-30 00:00:00

abstract：:Recombinant E. coli that produce light were found in a clone library of hybrid plasmids containing DNA from the marine bacterium Vibrio fischeri. All luminescent clones had a 16 kb insert that encoded enzymatic activities for the light reaction as well as regulatory functions necessary for expression of the luminescen...

journal_title：Cell

authors： Engebrecht J,Nealson K,Silverman M

更新日期：1983-03-01 00:00:00

abstract：:Polycomb group proteins control a hierarchy of gene expression during the differentiation of stem cells. In this issue, Ezhkova et al. (2009) show that repression mediated by Polycomb proteins controls the timing of differentiation of precursor cells of the epidermal lineage. ...

journal_title：Cell

authors： Pirrotta V

更新日期：2009-03-20 00:00:00

abstract：:The small molecular weight RNAs of the HeLa cell have been located in specific subcellular fractions. SnA is located in the nucleolus and is partially bonded to nucleolar 28S RNA. SnD, the most abundant of the small nuclear RNAs, is partially released from the nucleus when the nuclear preparation is briefly warmed. Sn...

journal_title：Cell

authors： Zieve G,Penman S

更新日期：1976-05-01 00:00:00

abstract：:In this issue of Cell, two articles show that tumor-specific changes in HLA-mediated antigen presentation affect tumor immunogenicity and may play a role in shaping cancer cell survival. ...

journal_title：Cell

authors： Vokes NI,Van Allen EM

更新日期：2017-11-30 00:00:00

abstract：:Plants, compared to animals, exhibit an amazing adaptability and plasticity in their development. This is largely dependent on the ability of plants to form new organs, such as lateral roots, leaves, and flowers during postembryonic development. Organ primordia develop from founder cell populations into organs by coor...

journal_title：Cell

authors： Benková E,Michniewicz M,Sauer M,Teichmann T,Seifertová D,Jürgens G,Friml J

更新日期：2003-11-26 00:00:00

abstract：:Genetic screening identifies the atypical tetraspanin TM4SF1 as a strong mediator of metastatic reactivation of breast cancer. Intriguingly, TM4SF1 couples the collagen receptor tyrosine kinase DDR1 to the cortical adaptor syntenin 2 and, hence, to PKCα. The latter kinase phosphorylates and activates JAK2, leading to ...

journal_title：Cell

authors： Gao H,Chakraborty G,Zhang Z,Akalay I,Gadiya M,Gao Y,Sinha S,Hu J,Jiang C,Akram M,Brogi E,Leitinger B,Giancotti FG

更新日期：2016-06-30 00:00:00

abstract：:Rare diseases are powerful windows into biological processes and can serve as models for the development of therapeutic strategies. The progress made on the premature aging disorder Progeria is a shining example of the impact that studies of rare diseases can have. ...

journal_title：Cell

authors： Gordon LB,Rothman FG,López-Otín C,Misteli T

更新日期：2014-01-30 00:00:00

abstract：:In this issue of Cell, Noma et al. (2006) show that B-boxes and TFIIIC limit the spread of heterochromatin at the silent mat region in the fission yeast genome. Global analysis of TFIIIC distribution revealed dispersed sites of association that coalesce at the nuclear periphery, suggesting that TFIIIC may act as a bar...

journal_title：Cell

authors： Wallrath LL,Geyer PK

更新日期：2006-06-02 00:00:00

abstract：:The bHLH-ZIP protein Mad heterodimerizes with Max as a sequence-specific transcriptional repressor. Mad is rapidly induced upon differentiation, and the associated switch from Myc-Max to Mad-Max heterocomplexes seem to repress genes normally activated by Myc-Max. We have identified two related mammalian cDNAs that enc...

journal_title：Cell

authors： Ayer DE,Lawrence QA,Eisenman RN

更新日期：1995-03-10 00:00:00

abstract：:During the SOS response, LexA repressor is inactivated by specific cleavage. Although cleavage requires RecA protein in vivo, RecA acts indirectly as a coprotease by stimulating an inherent self-cleavage activity of LexA. In lambda lysogens, cleavage of lambda Cl repressor in a similar but far slower reaction results ...

journal_title：Cell

authors： Kim B,Little JW

更新日期：1993-06-18 00:00:00

abstract：:Fission yeast Cid13 and budding yeast Trf4/5 are members of a newly identified nucleotidyltransferase family conserved from yeast to man. Trf4/5 are thought to be essential DNA polymerases. We report that Cid13 is a poly(A) polymerase. Unlike conventional poly(A) polymerases, which act in the nucleus and indiscriminat...

journal_title：Cell

authors： Saitoh S,Chabes A,McDonald WH,Thelander L,Yates JR,Russell P

更新日期：2002-05-31 00:00:00

abstract：:Microtubule-dependent motor, murine KIF3B, was disrupted by gene targeting. The null mutants did not survive beyond midgestation, exhibiting growth retardation, pericardial sac ballooning, and neural tube disorganization. Prominently, the left-right asymmetry was randomized in the heart loop and the direction of embry...

journal_title：Cell

authors： Nonaka S,Tanaka Y,Okada Y,Takeda S,Harada A,Kanai Y,Kido M,Hirokawa N

更新日期：1998-12-11 00:00:00

abstract：:Chemotherapy results in a frequent yet poorly understood syndrome of long-term neurological deficits. Neural precursor cell dysfunction and white matter dysfunction are thought to contribute to this debilitating syndrome. Here, we demonstrate persistent depletion of oligodendrocyte lineage cells in humans who received...

journal_title：Cell

authors： Gibson EM,Nagaraja S,Ocampo A,Tam LT,Wood LS,Pallegar PN,Greene JJ,Geraghty AC,Goldstein AK,Ni L,Woo PJ,Barres BA,Liddelow S,Vogel H,Monje M

更新日期：2019-01-10 00:00:00

abstract：:Expression of human immunodeficiency virus type 1 structural proteins requires both the viral Rev trans-activator and its cis-acting RNA target sequence, the Rev response element (RRE). The RRE has been mapped to a conserved region of the HIV-1 env gene and is predicted to form a complex, highly stable RNA stem-loop s...

journal_title：Cell

authors： Malim MH,Tiley LS,McCarn DF,Rusche JR,Hauber J,Cullen BR

更新日期：1990-02-23 00:00:00

abstract：:The elucidation of the genetic code remains among the most influential discoveries in biology. While innumerable studies have validated the general universality of the code and its value in predicting and analyzing protein coding sequences, established and emerging work has also suggested that full genome decryption m...

journal_title：Cell

authors： Brar GA

更新日期：2016-12-15 00:00:00

abstract：:Yeast chromosomes terminate in tracts of simple repetitive DNA (poly[G1-3T]). Mutations in the gene TEL1 result in shortened telomeres. Sequence analysis of TEL1 indicates that it encodes a very large (322 kDa) protein with amino acid motifs found in phosphatidylinositol/protein kinases. The closest homolog to TEL1 is...

journal_title：Cell

authors： Greenwell PW,Kronmal SL,Porter SE,Gassenhuber J,Obermaier B,Petes TD

更新日期：1995-09-08 00:00:00

abstract：:Compared to sperm nuclei, nuclei from adult somatic cells replicate inefficiently in frog egg extract. In this issue of Cell, Lemaitre et al. (2005) show that pre-exposure of erythrocyte nuclei to a mitotic extract removes this difference, reorganizes the chromatin into shorter loops, and allows replication at much sh...

journal_title：Cell

authors： Laskey R

更新日期：2005-12-02 00:00:00

abstract：:X-ray studies have established that the structure of a right-handed, Watson-Crick double helix can change from place to place along its length as a function of base sequence. The base pairs transmit deformations out to the phosphate backbone, where they can then be recognized by proteins and other DNA-binding reagents...

journal_title：Cell

authors： Drew HR,Travers AA

更新日期：1984-06-01 00:00:00

abstract：:The differentiation of body-wall muscle cells was studied in the nematode Caenorhabditis elegans. Specific antibodies to myosin and paramyosin, major protein constituents of differentiated muscle, react with mesodermal cells in wild-type embryos towards the end of the first half of embryogenesis. Immunoreactive cells ...

journal_title：Cell

authors： Gossett LA,Hecht RM,Epstein HF

更新日期：1982-08-01 00:00:00

abstract：:The membrane-associated carboxypeptidase angiotensin-converting enzyme 2 (ACE2) is an essential regulator of heart function. Now, Li at al. identify and characterize an unexpected second function of ACE2 as a partner of the SARS-CoV spike glycoprotein in mediating virus entry and cell fusion. ...

journal_title：Cell

authors： Dimitrov DS

更新日期：2003-12-12 00:00:00

abstract：:A clonally diverse anticipatory repertoire in which each lymphocyte bears a unique antigen receptor is the central feature of the adaptive immune system that evolved in our vertebrate ancestors. The survival advantage gained through adding this type of adaptive immune system to a pre-existing innate immune system led ...

journal_title：Cell

authors： Cooper MD,Alder MN

更新日期：2006-02-24 00:00:00

abstract：:Signaling by the epidermal growth factor receptor requires an allosteric interaction between the kinase domains of two receptors, whereby one activates the other. We show that the intracellular juxtamembrane segment of the receptor, known to potentiate kinase activity, is able to dimerize the kinase domains. The C-ter...

journal_title：Cell

authors： Jura N,Endres NF,Engel K,Deindl S,Das R,Lamers MH,Wemmer DE,Zhang X,Kuriyan J

更新日期：2009-06-26 00:00:00

abstract：:The mipA gene of A. nidulans encodes a newly discovered member of the tubulin superfamily of proteins, gamma-tubulin. In A. nidulans, gamma-tubulin is essential for nuclear division and microtubule assembly and is associated with the spindle pole body, the fungal microtubule organizing center. By low stringency hybrid...

journal_title：Cell

authors： Zheng Y,Jung MK,Oakley BR

更新日期：1991-05-31 00:00:00

abstract：:Gene silencing is instrumental to interrogate gene function and holds promise for therapeutic applications. Here, we repurpose the endogenous retroviruses' silencing machinery of embryonic stem cells to stably silence three highly expressed genes in somatic cells by epigenetics. This was achieved by transiently expres...

journal_title：Cell

authors： Amabile A,Migliara A,Capasso P,Biffi M,Cittaro D,Naldini L,Lombardo A

更新日期：2016-09-22 00:00:00