DNAase I encapsulated in liposomes can induce neoplastic transformation of Syrian hamster embryo cells in culture.

abstract：:The TDS4 gene of S. cerevisiae was isolated as an allele-specific high copy suppressor of mutations within the basic region of the TATA-binding protein (TBP). The gene is essential for viability and encodes a 596 aa protein. The first 300 aa of the TDS4 protein exhibit significant sequence similarity to the RNA polyme...

journal_title：Cell

authors： Buratowski S,Zhou H

更新日期：1992-10-16 00:00:00

abstract：:Neurotrophic factors are essential for neuronal survival and function. Recent data have demonstrated that the product of the tyrosine kinase trk proto-oncogene binds NGF and is a component of the high affinity NGF receptor. Analysis of the trkB gene product, gp145trkB, in NIH 3T3 cells indicates that this tyrosine kin...

journal_title：Cell

authors： Soppet D,Escandon E,Maragos J,Middlemas DS,Reid SW,Blair J,Burton LE,Stanton BR,Kaplan DR,Hunter T,Nikolics K,Parada LF

更新日期：1991-05-31 00:00:00

abstract：:Ventral midline cells at different rostrocaudal levels of the central nervous system exhibit distinct properties but share the ability to pattern the dorsoventral axis of the neural tube. We show here that ventral midline cells acquire distinct identities in response to the different signaling activities of underlying...

journal_title：Cell

authors： Dale JK,Vesque C,Lints TJ,Sampath TK,Furley A,Dodd J,Placzek M

更新日期：1997-07-25 00:00:00

abstract：:Suppressor of Hairless [Su(H)]/Lag-1/RBP-Jkappa/CBF1 is the only known transducing transcription factor for Notch receptor signaling. Here, we show that Su(H) has three distinct functions in the development of external mechanosensory organs in Drosophila: Notch-dependent transcriptional activation and a novel auto-rep...

journal_title：Cell

authors： Barolo S,Walker RG,Polyanovsky AD,Freschi G,Keil T,Posakony JW

更新日期：2000-12-08 00:00:00

abstract：:Elucidation of endogenous cellular protein-protein interactions and their networks is most desirable for biological studies. Here we report our study of endogenous human coregulator protein complex networks obtained from integrative mass spectrometry-based analysis of 3290 affinity purifications. By preserving weak pr...

journal_title：Cell

authors： Malovannaya A,Lanz RB,Jung SY,Bulynko Y,Le NT,Chan DW,Ding C,Shi Y,Yucer N,Krenciute G,Kim BJ,Li C,Chen R,Li W,Wang Y,O'Malley BW,Qin J

更新日期：2011-05-27 00:00:00

abstract：:Neuroinflammation is being increasingly recognized as a potential mediator of cognitive impairments in various neurological conditions. Habbas et al. demonstrate that the pro-inflammatory cytokine tumor necrosis factor alpha signals through astrocytes to alter synaptic transmission and impair cognition in a mouse mode...

journal_title：Cell

authors： Osso LA,Chan JR

更新日期：2015-12-17 00:00:00

abstract：:Interactions between similar but not identical (homeologous) DNA sequences play an important biological role in the evolution of genes and genomes. To gain insight into the underlying molecular mechanism(s) of genetic recombination, we have studied inter- and intramolecular homeologous recombination in S. cerevisiae d...

journal_title：Cell

authors： Mézard C,Pompon D,Nicolas A

更新日期：1992-08-21 00:00:00

abstract：:The eukaryotic 20S proteasome is known to associate with the IFN gamma-inducible regulator PA28. We analyzed the kinetics of product generation by 20S proteasomes with and without PA28. In the absence of PA28, the 20S proteasome rapidly generates peptides that have been cleaved only once, while internal fragments accu...

journal_title：Cell

authors： Dick TP,Ruppert T,Groettrup M,Kloetzel PM,Kuehn L,Koszinowski UH,Stevanović S,Schild H,Rammensee HG

更新日期：1996-07-26 00:00:00

abstract：:The molecular nature of mutations arising in dysgenic hybrids between P and M Drosophila melanogaster strains has been investigated. Seven independent mutations at the white locus were examined, and these fell into two classes on the basis of their genetic and structural properties. The five mutations comprising the f...

journal_title：Cell

authors： Rubin GM,Kidwell MG,Bingham PM

更新日期：1982-07-01 00:00:00

abstract：:The lack of in vitro prostate cancer models that recapitulate the diversity of human prostate cancer has hampered progress in understanding disease pathogenesis and therapy response. Using a 3D organoid system, we report success in long-term culture of prostate cancer from biopsy specimens and circulating tumor cells....

journal_title：Cell

authors： Gao D,Vela I,Sboner A,Iaquinta PJ,Karthaus WR,Gopalan A,Dowling C,Wanjala JN,Undvall EA,Arora VK,Wongvipat J,Kossai M,Ramazanoglu S,Barboza LP,Di W,Cao Z,Zhang QF,Sirota I,Ran L,MacDonald TY,Beltran H,Mosquera J

更新日期：2014-09-25 00:00:00

abstract：:We constructed rabbit beta-globin genes with deletions in the large intron, extending from the midpoint toward the 5' or 3' splice sites. Analysis of transcripts in transformed HeLa cells showed that six 5' proximal intron nucleotides allowed normal splicing. Correct splicing at the 3' splice site required 12 or more ...

journal_title：Cell

authors： Wieringa B,Hofer E,Weissmann C

更新日期：1984-07-01 00:00:00

abstract：:Cyclic dinucleotides (CDNs) have been previously recognized as important secondary signaling molecules in bacteria and, more recently, in mammalian cells. In the former case, they represent secondary messengers affecting numerous responses of the prokaryotic cell, whereas in the latter, they act as agonists of the inn...

journal_title：Cell

authors： Danilchanka O,Mekalanos JJ

更新日期：2013-08-29 00:00:00

abstract：:Gastrointestinal enterochromaffin cells regulate bone and gut homeostasis via serotonin (5-hydroxytryptamine [5-HT]) production. A recent report suggested that gut microbes regulate 5-HT levels; however, the precise underlying molecular mechanisms are unexplored. Here, we reveal that the cation channel Piezo1 in the g...

journal_title：Cell

authors： Sugisawa E,Takayama Y,Takemura N,Kondo T,Hatakeyama S,Kumagai Y,Sunagawa M,Tominaga M,Maruyama K

更新日期：2020-08-06 00:00:00

abstract：:We have shown previously that the putative oncogene pim-1 is frequently activated by provirus insertion in murine leukemia virus-induced T cell lymphomas. Here we describe the structure of the pim-1 gene as determined by sequencing genomic and cDNA clones. The gene has an open reading frame, encoding a protein of 313 ...

journal_title：Cell

authors： Selten G,Cuypers HT,Boelens W,Robanus-Maandag E,Verbeek J,Domen J,van Beveren C,Berns A

更新日期：1986-08-15 00:00:00

abstract：:Notch signaling is a key developmental pathway that is subject to frequent genetic and epigenetic perturbations in many different human tumors. Here we investigate whether long noncoding RNA (lncRNA) genes, in addition to mRNAs, are key downstream targets of oncogenic Notch1 in human T cell acute lymphoblastic leukemi...

journal_title：Cell

authors： Trimarchi T,Bilal E,Ntziachristos P,Fabbri G,Dalla-Favera R,Tsirigos A,Aifantis I

更新日期：2014-07-31 00:00:00

abstract：:Pathways that govern stem cell (SC) function are often subverted in cancer. Here, we report the isolation to near purity of human normal mammary SCs (hNMSCs), from cultured mammospheres, on the basis of their ability to retain the lipophilic dye PKH26 as a consequence of their quiescent nature. PKH26-positive cells po...

journal_title：Cell

authors： Pece S,Tosoni D,Confalonieri S,Mazzarol G,Vecchi M,Ronzoni S,Bernard L,Viale G,Pelicci PG,Di Fiore PP

更新日期：2010-01-08 00:00:00

abstract：:The small ribonucleoproteins recognized by anti-La autoantibodies contain a heterogeneous mixture of small RNAs from uninfected mammalian cells. The identity of many of these has now been established by the discovery of precursor forms of 5S rRNA and of certain tRNAs among La RNAs from HeLa cells. The small fraction o...

journal_title：Cell

authors： Rinke J,Steitz JA

更新日期：1982-05-01 00:00:00

abstract：:In the mammalian brain, the specification of a single axon and multiple dendrites occurs early in the differentiation of most neuron types. Numerous intracellular signaling events for axon specification have been described in detail. However, the identity of the extracellular factor(s) that initiate neuronal polarity ...

journal_title：Cell

authors： Yi JJ,Barnes AP,Hand R,Polleux F,Ehlers MD

更新日期：2010-07-09 00:00:00

abstract：:In the mouse, the zona pellucida (ZP) glycoprotein ZP3 both binds intact sperm and induces acrosomal exocytosis. The subsequent signaling pathway(s) is still uncertain, but Gi-like proteins have been implicated. By analogy with other signal transduction mechanisms, we examined anti-phosphotyrosine antibody reactivity ...

journal_title：Cell

authors： Leyton L,Saling P

更新日期：1989-06-30 00:00:00

abstract：:Conditions are described for programming with active transcription complexes essentially all the Xenopus 5S RNA genes added to an extract of Xenopus oocyte nuclei. We call this rate enhancement. Transcription by SP6 RNA polymerase of either strand of a Xenopus 5S RNA gene is unimpeded by the presence of a complete tra...

journal_title：Cell

authors： Wolffe AP,Jordan E,Brown DD

更新日期：1986-02-14 00:00:00

abstract：:In causing disease, pathogens outmaneuver host defenses through a dedicated arsenal of virulence determinants that specifically bind or modify individual host molecules. This dedication limits the intruder to a defined range of hosts. Newly emerging diseases mostly involve existing pathogens whose arsenal has been alt...

journal_title：Cell

authors： Wollert T,Pasche B,Rochon M,Deppenmeier S,van den Heuvel J,Gruber AD,Heinz DW,Lengeling A,Schubert WD

更新日期：2007-06-01 00:00:00

abstract：:We show that a functional component of the C. elegans mitotic machinery regulates X chromosome gene expression. This protein, MIX-1, is a member of the dosage compensation complex that associates specifically with hermaphrodite X chromosomes to reduce their gene expression during interphase. MIX-1 also associates with...

journal_title：Cell

authors： Lieb JD,Albrecht MR,Chuang PT,Meyer BJ

更新日期：1998-01-23 00:00:00

abstract：:The 50 amino acid form of TGF-alpha is cleaved from a conserved integral membrane glycoprotein by a protease that, in many tumor cells, appears to be limiting. To test whether the membrane-bound precursor has biological activity in the absence of processing, we introduced amino acid substitutions at the proteolytic cl...

journal_title：Cell

authors： Wong ST,Winchell LF,McCune BK,Earp HS,Teixidó J,Massagué J,Herman B,Lee DC

更新日期：1989-02-10 00:00:00

abstract：:Sexual reproduction predominates among eukaryotic organisms on our planet. While debate continues over why this should be so, burgeoning genomic and functional information now allows us to begin to think reasonably about some of the events that may have occurred to make sex possible in the first place. ...

journal_title：Cell

authors： Villeneuve AM,Hillers KJ

更新日期：2001-09-21 00:00:00

abstract：:S. cerevisiae inherits its vacuole by projecting vacuole-derived membrane vesicles and tubules into the bud, where they fuse to establish the daughter vacuole. This homotypic fusion event can be assayed in vitro. It requires Sec17p and Sec18p, the homologs of the mammalian alpha-SNAP and NSF, which cooperate in multip...

journal_title：Cell

authors： Mayer A,Wickner W,Haas A

更新日期：1996-04-05 00:00:00

abstract：:Recent biochemical and genetic studies indicate that in addition to the octamer-binding proteins Oct-1 and Oct-2, other B cell components are required for lymphoid-restricted, octamer site-mediated immunoglobulin gene promoter activity. Using a genetic screen in yeast, we have isolated B cell-derived cDNAs encoding Oc...

journal_title：Cell

authors： Strubin M,Newell JW,Matthias P

更新日期：1995-02-10 00:00:00

abstract：:Several metabolic alterations accumulate over time along with a reduction in biological fitness, suggesting the existence of a "metabolic clock" that controls aging. Multiple inborn defects in metabolic circuitries accelerate aging, whereas genetic loci linked to exceptional longevity influence metabolism. Each of the...

journal_title：Cell

authors： López-Otín C,Galluzzi L,Freije JMP,Madeo F,Kroemer G

更新日期：2016-08-11 00:00:00

abstract：:The yeast SIR2 gene is involved in regulating nucleosome phasing and transcription in the mating type system. We have found that SIR2 also plays another important role in the cell. Specifically, in wild-type SIR2 strains recombination between the tandemly repeated ribosomal RNA genes is depressed. In sir2 mutants, bot...

journal_title：Cell

authors： Gottlieb S,Esposito RE

更新日期：1989-03-10 00:00:00

abstract：:The promoter specificity of transcriptional activators is generally thought to be conferred by the specificity of the DNA-binding domain, which brings the activation domain to the appropriate promoter sequence. We show here, however, that Oct-1 and Oct-2 can differentially activate transcription not through DNA bindin...

journal_title：Cell

authors： Tanaka M,Lai JS,Herr W

更新日期：1992-02-21 00:00:00

abstract：:G1-specific transcriptional activation by Cln3/CDK initiates the budding yeast cell cycle. To identify targets of Cln3/CDK, we analyzed the SBF and MBF transcription factor complexes by multidimensional protein interaction technology (MudPIT). Whi5 was identified as a stably bound component of SBF but not MBF. Inactiv...

journal_title：Cell

authors： de Bruin RA,McDonald WH,Kalashnikova TI,Yates J 3rd,Wittenberg C

更新日期：2004-06-25 00:00:00