The GAP-related domain of the neurofibromatosis type 1 gene product interacts with ras p21.

abstract：:Invasive lobular carcinoma (ILC) is the second most prevalent histologic subtype of invasive breast cancer. Here, we comprehensively profiled 817 breast tumors, including 127 ILC, 490 ductal (IDC), and 88 mixed IDC/ILC. Besides E-cadherin loss, the best known ILC genetic hallmark, we identified mutations targeting PTE...

journal_title：Cell

authors： Ciriello G,Gatza ML,Beck AH,Wilkerson MD,Rhie SK,Pastore A,Zhang H,McLellan M,Yau C,Kandoth C,Bowlby R,Shen H,Hayat S,Fieldhouse R,Lester SC,Tse GM,Factor RE,Collins LC,Allison KH,Chen YY,Jensen K,Johnson NB,O

更新日期：2015-10-08 00:00:00

abstract：:Cholera toxin inhibition of progesterone-induced meiosis of Xenopus laevis oocytes in vitro has been correlated with increased cAMP levels. Inhibition of germinal vesicle breakdown (Gvbd) and cAMP increase occurred after a lag period of 2 hr, when cholera toxin was injected, or 4--5 hr, when applied externally. The ab...

journal_title：Cell

authors： Schorderet-Slatkine S,Schorderet M,Boquet P,Godeau F,Baulieu EE

更新日期：1978-12-01 00:00:00

abstract：:The DNA-binding region of Myb consists of three imperfect tandem repeats (R1, R2, and R3). We have determined the solution structure of a specific DNA complex of the minimum DNA-binding domain (R2R3) by heteronuclear multidimensional NMR. Both R2 and R3 contain three helices, and the third helix in each is found to be...

journal_title：Cell

authors： Ogata K,Morikawa S,Nakamura H,Sekikawa A,Inoue T,Kanai H,Sarai A,Ishii S,Nishimura Y

更新日期：1994-11-18 00:00:00

abstract：:Spindle assembly required during mitosis depends on microtubule polymerization. We demonstrate that the evolutionarily conserved low-complexity protein, BuGZ, undergoes phase transition or coacervation to promote assembly of both spindles and their associated components. BuGZ forms temperature-dependent liquid droplet...

journal_title：Cell

authors： Jiang H,Wang S,Huang Y,He X,Cui H,Zhu X,Zheng Y

更新日期：2015-09-24 00:00:00

abstract：:daughterless (da) has multiple functions in Drosophila embryonic development: maternal da activity is necessary for proper sex determination, and zygotic da activity is necessary for formation of the peripheral nervous system. We have cloned the region containing da and have found that five recessive lethal da mutatio...

journal_title：Cell

authors： Caudy M,Vässin H,Brand M,Tuma R,Jan LY,Jan YN

更新日期：1988-12-23 00:00:00

abstract：:The ongoing pandemic of a new human coronavirus, SARS-CoV-2, has generated enormous global concern. We and others in China were involved in the initial genome sequencing of the virus. Herein, we describe what genomic data reveal about the emergence SARS-CoV-2 and discuss the gaps in our understanding of its origins. ...

journal_title：Cell

authors： Zhang YZ,Holmes EC

更新日期：2020-04-16 00:00:00

abstract：:Upon heat shock, Drosophila Kc cells still contain normal cellular messenger RNAs in the cytoplasm. The distribution of these 25 degrees C mRNAs between polysomes and the postpolysomal fraction of heat-shocked cells appears unaltered as compared with control cells. The translatability of these normal cellular messages...

journal_title：Cell

authors： Krüger C,Benecke BJ

更新日期：1981-02-01 00:00:00

abstract：:The nucleus is connected to the cytoskeleton, and these connections are involved in multiple functions such as nuclear positioning, shape and stiffness, cytoskeleton organization, mechanotransduction, gene expression, chromosome positioning, DNA repair, and cell migration. ...

journal_title：Cell

authors： Janota CS,Calero-Cuenca FJ,Costa J,Gomes ER

更新日期：2017-05-18 00:00:00

abstract：:The sigma factor sigma 70 of E. coli RNA polymerase acts not only in initiation, but also at an early stage of elongation to induce a transcription pause, and simultaneously to allow the phage lambda gene Q transcription antiterminator to act. We identify the signal in DNA that induces early pausing to be a version of...

journal_title：Cell

authors： Ring BZ,Yarnell WS,Roberts JW

更新日期：1996-08-09 00:00:00

abstract：:The V(D)J recombinase subunits Rag-1 and Rag-2 mediate assembly of antigen receptor gene segments. We studied the mechanisms of DNA recognition by Rag-1/Rag-2 using surface plasmon resonance. The critical step for signal recognition is binding of Rag-1 to the nonamer. This is achieved by a region of Rag-1 homologous t...

journal_title：Cell

authors： Spanopoulou E,Zaitseva F,Wang FH,Santagata S,Baltimore D,Panayotou G

更新日期：1996-10-18 00:00:00

abstract：:The pathway of RNA polymerase entry at the lac promoter was studied by investigating the relationship between the promoter and a weak, overlapping polymerase interaction site (P2). If polymerase is made to enter the DNA by binding in vitro at this P2 site, cyclic AMP receptor protein (CRP) actively removes polymerase ...

journal_title：Cell

authors： Meiklejohn AL,Gralla JD

更新日期：1985-12-01 00:00:00

abstract：:High-grade serous ovarian cancer (HGSC) exhibits extensive malignant clonal diversity with widespread but non-random patterns of disease dissemination. We investigated whether local immune microenvironment factors shape tumor progression properties at the interface of tumor-infiltrating lymphocytes (TILs) and cancer c...

journal_title：Cell

authors： Zhang AW,McPherson A,Milne K,Kroeger DR,Hamilton PT,Miranda A,Funnell T,Little N,de Souza CPE,Laan S,LeDoux S,Cochrane DR,Lim JLP,Yang W,Roth A,Smith MA,Ho J,Tse K,Zeng T,Shlafman I,Mayo MR,Moore R,Failmezger

更新日期：2018-06-14 00:00:00

abstract：:Inflammation is associated with many neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, and multiple sclerosis. In this Review, we discuss inducers, sensors, transducers, and effectors of neuroinflammation that contribute to neuronal dysfunction and death. Al...

journal_title：Cell

authors： Glass CK,Saijo K,Winner B,Marchetto MC,Gage FH

更新日期：2010-03-19 00:00:00

abstract：:The mechanisms of transcriptional activation in heterochromatin were investigated by using FISH to directly visualize changes in chromatin organization during activation of a heterochromatic lambda5 transgene. A DNase I hypersensitive site was shown to relocate the transgene to the outside of the pericentromeric heter...

journal_title：Cell

authors： Lundgren M,Chow CM,Sabbattini P,Georgiou A,Minaee S,Dillon N

更新日期：2000-11-22 00:00:00

abstract：:Axonal transport has been intensively examined as a good model for studying the mechanism of organelle transport in cells, but it is still unclear how different types of membrane organelles are transported through the nerve axon. To elucidate the function of this mechanism, we have cloned KIF1A, a novel neuron-specifi...

journal_title：Cell

authors： Okada Y,Yamazaki H,Sekine-Aizawa Y,Hirokawa N

更新日期：1995-06-02 00:00:00

abstract：:The E. coli replication fork synthesizes DNA at the rate of nearly 1000 nt/s. We show here that an interaction between the tau subunit of the replicative polymerase (the DNA polymerase III holoenzyme) and the replication fork DNA helicase (DnaB) is required to mediate this high rate of replication fork movement. In th...

journal_title：Cell

authors： Kim S,Dallmann HG,McHenry CS,Marians KJ

更新日期：1996-02-23 00:00:00

abstract：:Xenopus laevis oocytes were used as a model system to study the intracellular fate of proteins incorporated by endocytosis. We found that the intracellular stability and compartmentation of proteins incorporated by receptor-mediated endocytosis differed substantially from that of proteins incorporated by nonspecific e...

journal_title：Cell

authors： Opresko L,Wiley HS,Wallace RA

更新日期：1980-11-01 00:00:00

abstract：:The 5' terminal sequences of several adenovirus 2 (Ad2) mRNAs, isolated late in infection, are complementary to sequences within the Ad2 genome which are remote from the DNA from which the main coding sequence of each mRNA is transcribed. This has been observed by forming RNA displacement loops (R loops) between Ad2 D...

journal_title：Cell

authors： Chow LT,Gelinas RE,Broker TR,Roberts RJ

更新日期：1977-09-01 00:00:00

abstract：:Childhood asthma is typically associated with a polarized Th2 response to inhaled allergens and is influenced by genetics. Yang et al. show that the asthma susceptibility gene DENND1B controls cytokine production in Th2 lymphocytes by controlling the rate of TCR internalization and routing to endosomes, providing a mo...

journal_title：Cell

authors： Godar M,Lambrecht BN

更新日期：2016-01-14 00:00:00

abstract：:Chemotherapy results in a frequent yet poorly understood syndrome of long-term neurological deficits. Neural precursor cell dysfunction and white matter dysfunction are thought to contribute to this debilitating syndrome. Here, we demonstrate persistent depletion of oligodendrocyte lineage cells in humans who received...

journal_title：Cell

authors： Gibson EM,Nagaraja S,Ocampo A,Tam LT,Wood LS,Pallegar PN,Greene JJ,Geraghty AC,Goldstein AK,Ni L,Woo PJ,Barres BA,Liddelow S,Vogel H,Monje M

更新日期：2019-01-10 00:00:00

abstract：:In Saccharomyces cerevisiae, mothers and daughters have distinct fates. We show that Cbk1 kinase and its interacting protein Mob2 regulate this asymmetry by inducing daughter-specific genetic programs. Daughter-specific expression is due to Cbk1/Mob2-dependent activation and localization of the Ace2 transcription fact...

journal_title：Cell

authors： Colman-Lerner A,Chin TE,Brent R

更新日期：2001-12-14 00:00:00

abstract：:Telomeres are specialized protein-DNA complexes that compose the ends of eukaryotic chromosomes. Telomeres protect chromosome termini from degradation and recombination and act together with telomerase to ensure complete genome replication. We have determined the crystal structure of the two-subunit Oxytricha nova tel...

journal_title：Cell

authors： Horvath MP,Schweiker VL,Bevilacqua JM,Ruggles JA,Schultz SC

更新日期：1998-12-23 00:00:00

abstract：:The modularity of protein architecture and the diversity of protein domains hint at a vast combinatorial richness. But evolution appears to have been relatively conservative about selecting new combinations. When a particular grouping of domains within a polypeptide chain can perform a concerted function, that combina...

journal_title：Cell

authors： Harrison SC

更新日期：2003-03-21 00:00:00

abstract：:We present genetic evidence that integrins regulate epithelial-mesenchymal interactions during organogenesis. Mice with a mutation in the alpha8 gene do not express the integrin alpha8 beta1 and exhibit profound deficits in kidney morphogenesis. In wild-type animals, inductive interactions between the ureteric epithel...

journal_title：Cell

authors： Müller U,Wang D,Denda S,Meneses JJ,Pedersen RA,Reichardt LF

更新日期：1997-03-07 00:00:00

abstract：:Activation of Agouti-related peptide (AgRP) neurons potently promotes feeding, and chronically altering their activity also affects peripheral glucose homeostasis. We demonstrate that acute activation of AgRP neurons causes insulin resistance through impairment of insulin-stimulated glucose uptake into brown adipose t...

journal_title：Cell

authors： Steculorum SM,Ruud J,Karakasilioti I,Backes H,Engström Ruud L,Timper K,Hess ME,Tsaousidou E,Mauer J,Vogt MC,Paeger L,Bremser S,Klein AC,Morgan DA,Frommolt P,Brinkkötter PT,Hammerschmidt P,Benzing T,Rahmouni K,Wunder

更新日期：2016-03-24 00:00:00

abstract：:Developing cells of the cellular slime mold Dictyostelium discoideum release a low molecular weight metabolite (Slug Turning Factor, STF) which, at high uniform concentrations, interferes with phototaxis and thermotaxis by D. discoideum slugs. D. discoideum slugs migrating in darkness are repelled by (exhibit negative...

journal_title：Cell

authors： Fisher PR,Smith E,Williams KL

更新日期：1981-03-01 00:00:00

abstract：:The functional consequences of glycan structural changes associated with cellular differentiation are ill defined. Herein, we investigate the role of glycan adducts to the O-glycosylated polypeptide stalk tethering the CD8alphabeta coreceptor to the thymocyte surface. We show that immature CD4(+)CD8(+) double-positive...

journal_title：Cell

authors： Moody AM,Chui D,Reche PA,Priatel JJ,Marth JD,Reinherz EL

更新日期：2001-11-16 00:00:00

abstract：:The effects of beta-estradiol (estrogen; a minor component of yeast cells) on S. cerevisiae cells in the G0 and G1 phases were examined. Results showed that estrogen stimulated the recovery of growth from G0 arrest induced by nutrient limitation or ts mutation of cdc35 (adenylate cyclase) in the early G1 phase, and in...

journal_title：Cell

authors： Tanaka S,Hasegawa S,Hishinuma F,Kurata S

更新日期：1989-05-19 00:00:00

abstract：:T cell dysfunction in cancer comes in many forms, with two new varieties reported in this issue. Daley et al. find that T cells expressing γδ T cell receptors (TCR) promote pancreatic tumor growth by inhibiting activation of T cells with conventional TCRs. Singer et al. characterize dysfunctional tumor infiltrating ly...

journal_title：Cell

authors： Sowell RT,Kaech SM

更新日期：2016-09-08 00:00:00

abstract：:We have analyzed the transcriptional regulation of plastid genes during chloroplast development in illuminated spinach cotyledons and during leaf formation. The RNAs encoded by plastid genes accumulate with different kinetics during the developmental transitions. Using a novel plastid run-on transcription assay we dem...

journal_title：Cell

authors： Deng XW,Gruissem W

更新日期：1987-05-08 00:00:00